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Literature summary for 5.4.2.10 extracted from

  • Yajima, A.; Takahashi, Y.; Shimazu, K.; Urano-Tashiro, Y.; Uchikawa, Y.; Karibe, H.; Konishi, K.
    Contribution of phosphoglucosamine mutase to the resistance of Streptococcus gordonii DL1 to polymorphonuclear leukocyte killing (2009), FEMS Microbiol. Lett., 297, 196-202.
    View publication on PubMed

Application

Application Comment Organism
medicine phosphoglucosamine mutase could be a a novel drug target Streptococcus gordonii

Protein Variants

Protein Variants Comment Organism
glmM mutant mutation resulted in increased sensitivity to polymorphonuclear leukocyte, PMN, -dependent killing, mutant induces increased superoxide anion production and lysozyme release by PMNs, mutant is more sensitive to lysozyme Streptococcus gordonii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-D-glucosamine 1-phosphate Streptococcus gordonii
-
D-glucosamine 6-phosphate
-
?
alpha-D-glucosamine 1-phosphate Streptococcus gordonii DL1
-
D-glucosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus gordonii
-
-
-
Streptococcus gordonii DL1
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucosamine 1-phosphate
-
Streptococcus gordonii D-glucosamine 6-phosphate
-
?
alpha-D-glucosamine 1-phosphate
-
Streptococcus gordonii DL1 D-glucosamine 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
GlmM
-
Streptococcus gordonii
phosphoglucosamine mutase
-
Streptococcus gordonii

General Information

General Information Comment Organism
physiological function phosphoglucosamine mutase catalyzes the interconversion of glucosamine 6-phosphate to glucosamine 1-phosphate, an essential step in the biosynthetic pathway leading to the formation of the peptidoglycan precursor uridine 5'-diphospho-N-acetylglucosamine Streptococcus gordonii