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Information on EC 1.11.1.13 - manganese peroxidase

for references in articles please use BRENDA:EC1.11.1.13

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IUBMB Comments

A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ . The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates . It is inactive with veratryl alcohol or nonphenolic substrates.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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2
Mn(II)
+
2
H+
+
H2O2
=
2
Mn(III)
+
2
H2O
2
+
2
+
=
2
+
2

Synonyms
manganese peroxidase, manganese-dependent peroxidase, lemnp2, il-mnp1, hybrid mn-peroxidase, short mnp, mnp-gy, peroxidase-m2, mnp-pgy, mrmnp1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
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PATHWAY SOURCE
PATHWAYS
MetaCyc
manganese oxidation I