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(2R)-5-nitroguanyl-2-([(2R,3S)-2-(cyclohexylmethyl)-3-cyclopropyl-3-[formyl(hydroxy)amino]propanoyl]-amino)-N-(1,3-thiazol-2-yl)pentanamide
-
-
(2R,3S)-N-[(1S)-4-(2-pyridylsulfonyl)guanyl-1-[(1,3-thiazol-2-ylamino)-carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-isobutylhexanamide
-
-
(2R,3S)-N-[(1S)-4-(2-pyridylsulfonyl)guanyl-1-[(1,3-thiazol-2-ylamino)-carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-[(4-methylcyclohexyl)-methyl]hexanamide
-
-
(2R,3S)-N-[(1S)-4-(2-pyridylsulfonyl)guanyl-1-[(1,3-thiazol-2-ylamino)-carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-[(5-methyl-2-thienyl)methyl]hexanamide
-
-
(2R,3S)-N-[(1S)-4-(2-pyridylsulfonyl)guanyl-1-[(1,3-thiazol-2-ylamino)-carbonyl]butyl]-3-[formyl(hydroxy)amino]-4-methyl-2-[(4-methylcyclohexyl)methyl]pentanamide
-
-
(2R,3S)-N-[(1S)-4-methanesulfonylguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-isobutyl-4-methylpentanamide
-
-
(2R,3S)-N-[(1S)-4-methanesulfonylguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-isobutylhexanamide
-
-
(2R,3S)-N-[(1S)-4-methanesulfonylguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-4-methyl-2-[(4-methylcyclohexyl)methyl]pentanamide
-
-
(2R,3S)-N-[(1S)-4-methanesulfonylguanyl-2-methyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl-(hydroxy)amino]-2-isobutyl-4-methylpentanamide
-
-
(2R,3S)-N-[(1S)-4-methanesulfonylguanyl-2-methyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl-(hydroxy)amino]-2-isobutylhexanamide
-
-
(2R,3S)-N-[(1S)-4-methanesulfonylguanyl-2-methyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-6,6,6-trifluoro-3-[formyl(hydroxy)amino]-2-isobutylhexanamide
-
-
(2R,3S)-N-[(1S)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-2-(cyclohexylmethyl)-3-[formyl(hydroxy)amino]hexanamide
-
-
(2R,3S)-N-[(1S)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-2-(cyclohexylmethyl)-6,6,6-trifluoro-3-[formyl(hydroxy)amino]hexanamide
-
-
(2R,3S)-N-[(1S)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-2-[(1S)-1-[formyl(hydroxy)amino]-2-phenylethyl]-4-methylpentanamide
-
-
(2R,3S)-N-[(1S)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-[5-methyl-2-thienylmethyl]hexanamide
-
-
(2R,3S)-N-[(1S)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-4-methyl-2-[(4-methylcyclohexyl)methyl]hexanamide
-
-
(2R,3S)-N-[(1S)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-4-methyl-2-[(4-methylcyclohexyl)methyl]pentanamide
-
-
(2R,3S)-N-[(1S,2R)-4-nitroguanyl-2-methyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl]-3-[formyl(hydroxy)amino]-2-isobutylhexanamide
-
-
(2R,3S)-N-{(1R)-4-nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl}-3-[formyl(hydroxy)amino]-2-isobutylhexanamide
-
-
(2S)-2-amino-5-({(E)-amino[(methylsulfonyl)imino]-methyl}amino)-N-(1,3-thiazol-2-yl)pentanamide hydrochloride
-
-
(2S)-2-[(tert-butoxycarbonyl)amino]-5-({(Z)-(methyl-sulfanyl)[(methylsulfonyl)imino]methyl}amino)pentanoic acid
-
-
(2S,3R)-2-[(tert-butoxycarbonyl)amino]-5-{[imino(2-oxido-2-oxohydrazino)methyl]amino}-3-methylpentanoic acid (3R) Nalpha-boc-Ngamma-nitro-3-methyl L-arginine
-
-
(2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-5-({(Z)-(methylsulfanyl)[(methylsulfonyl)imino]methyl}-amino)pentanoic acid
-
-
(2S,3R)-5-methanesulfonylguanyl-2-[((2R)-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-4-methylpentanoyl)amino]-3-methyl-N-(1,3-thiazol-2-yl)pentanamide
-
-
(2S,3R)-5-nitroguanyl-2-[((2R)-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-4-methylpentanoyl)amino]-3-methyl-N-(1,3-thiazol-2-yl)pentanamide
-
-
4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)-thiomorpholinecarboxamide
-
IC50: 0.05 mM
benzyl (1S,2R)-4-({(E)-amino[(methylsulfonyl)imino]-methyl}amino)-2-methyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butylcarbamate
-
-
DPC333
-
specific inhibitor
EndoH
-
full-length TACE is sensitive to EndoH, mature TACE is resistant
-
L-NG-(2-pyridylsulfonyl)arginine2-aminothiazole amide hydochloride
-
-
L-NG-nitroarginine 2-aminothiazole amide dihydrochloride
-
-
N(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-alanine amide
-
IC50: about 0.7 mM
PF-548
-
selective inhibitor
PKF241-466
-
maximum inhibition at 10 mg/kg
PKF242-484
-
maximum inhibition at 10 mg/kg
TAPI
-
selective inhibitor
TAPI-1
-
TAPI-1 blocks the processing of RA175/SynCAM1, a member of the immunoglobulin family 4. Furthermore, TAPI-1 increases the number of synaptophysin and RA175/SynCAM1 colocalization on the dendrites of neurons
tert-butyl (1S,2R)-4-{[imino(2-oxido-2-oxohydrazino)-methyl]amino}-2-methyl-1-[1,3-thiazol-2-ylaminocarbonyl]butylcarbamate
-
-
tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-4-pentenoate
-
-
tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-5-amino-3-methylpentanoate
-
-
tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-5-azido-3-methylpentanoate
-
-
tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-5-hydroxy-3-methylpentanoate
-
-
tert-butyl(1S)-4-({(Z)-(methylsulfanyl)[(methylsulfonyl)-imino]methyl}amino)-1-[(1,3-thiazol-2-ylamino)carbonyl]butylcarbamate
-
-
TIMP-3
-
presence of TIMP-3 inhibits shedding of lipoprotein-related protein I
-
tissue inhibitor of metalloproteinase-3
-
-
-
tissue inhibitor of metalloproteinases-3
-
natural inhibitor of ADAM17
-
[((3R,4S)-4-{[(benzyloxy)carbonyl]}-4-carboxy-3-methylbutyl)amino](imino)methanaminium nitrate (3R) 3-methyl L-arginine nitric acid salt
-
-
additional information
-
not inhibited by FN-439
-
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Buxbaum, J.D.; Liu, K.N.; Luo, Y.; Slack, J.L.; Stocking, K.L.; Peschon, J.J.; Johnson, R.S.; Castner, B.J.; Cerretti, D.P.; Black, R.A.
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
J. Biol. Chem.
273
27765-27767
1998
Homo sapiens, Mus musculus
brenda
Fiorucci, S.; Antonelli, E.; Migliorati, G.; Santucci, L.; Morelli, O.; Federici, B.; Morelli, A.
TNFalpha processing enzyme inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal injury in rats
Aliment. Pharmacol. Ther.
12
1139-1153
1998
Mus musculus, Rattus norvegicus
brenda
Cerretti, D.P.
Characterization of the tumor necrosis factor alpha-converting enzyme, TACE/ADAM17
Biochem. Soc. Trans.
27
219-223
1999
Homo sapiens, Mus musculus
brenda
Mizui, Y.; Yamazaki, K.; Sagane, K.; Tanaka, I.
cDNA cloning of mouse tumor necrosis factor-.alpha. converting enzyme (TACE) and partial analysis of its promoter
Gene
233
67-74
1999
Mus musculus
brenda
Moss, M.; Becherer, J.D.; Milla, M.; Pahel, G.; Lambert, M.; Andrews, R.; Frye, S.; Haffner, C.; Cowan, D.; Maloney, P.; Dixon, E.P.; Jansen, M.; Vitek, M.P.; Mitchell, J.; Leesnitzer, T.; Warner, J.; Conway, J.; Bickett, D.M.; Bird, M.; Priest, R.; Reinhard, J.; Lin, P.
TNF.alpha. converting enzyme
Metalloproteinases as targets for anti-inflammatory drugs, (Bottomley, K. M. K; Bradshaw, D. ; Nixon, J. S. eds. )
187-203
1999
Homo sapiens, Mus musculus, Mus musculus C3H/HEN
-
brenda
Becherer, J.D.; Lambert, M.H.; Andrews, R.C.
The tumor necrosis factor-alpha converting enzyme
Handbook of Experimental Pharmacology, (von der Helm, K. ; Korant, B. C. ; Cheronis, J. C. eds. )
140
235-258
2000
Homo sapiens, Mus musculus, Sus scrofa
-
brenda
Brou, C.; Logeat, F.; Gupta, N.; Bessia, C.; LeBail, O.; Doedens, J.R.; Cumano, A.; Roux, P.; Black, R.A.; Israel, A.
A novel proteolytic cleavage involved in notch signaling: the role of the disintegrin-metalloprotease TACE
Mol. Cell
5
207-216
2000
Homo sapiens, Mus musculus
brenda
Reddy, P.; Slack, J.L.; Davis, R.; Cerretti, D.P.; Kozlosky, C.J.; Blanton, R.A.; Shows, D.; Peschon, J.J.; Black, R.A.
Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
J. Biol. Chem.
275
14608-14614
2000
Homo sapiens, Homo sapiens (P78536), Mus musculus, Mus musculus EC-4
brenda
Rio, C.; Buxbaum, J.D.; Peschon, J.J.; Corfas, G.
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4
J. Biol. Chem.
275
10379-10387
2000
Mus musculus
brenda
Schloendorff, J.; Becherer, J.D.; Blobel, C.P.
Intracellular maturation and localization of the tumor necrosis factor alpha convertase (TACE)
Biochem. J.
347
131-138
2000
Chlorocebus aethiops, Homo sapiens, Mus musculus
-
brenda
Zhang, Y.; Jiang, J.; Black, R.A.; Baumann, G.; Frank, S.J.
Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation
Endocrinology
141
4342-4348
2000
Oryctolagus cuniculus, Homo sapiens, Mus musculus
brenda
Rabinowitz, M.H.; Andrews, R.C.; Becherer, J.D.; Bickett, D.M.; Bubacz, D.G.; Conway, J.G.; Cowan, D.J.; Gaul, M.; Glennon, K.; Lambert, M.H.; Leesnitzer, M.A.; McDougald, D.L.; Moss, M.L.; Musso, D.L.; Rizzolio, M.C.
Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
J. Med. Chem.
44
4252-4267
2001
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Lewis
brenda
Rovida, E.; Paccagnini, A.; Del Rosso, M.; Peschon, J.; Sbarba, P.D.
TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation
J. Immunol.
166
1583-1589
2001
Homo sapiens, Mus musculus
brenda
Skovronsky, D.M.; Fath, S.; Lee, V.M.Y.; Milla, M.E.
Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques
J. Neurobiol.
49
40-46
2001
Homo sapiens, Mus musculus
brenda
Tsou, C.L.; Haskell, C.A.; Charo, I.F.
Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine
J. Biol. Chem.
276
44622-44626
2001
Homo sapiens, Mus musculus
brenda
Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
J. Biol. Chem.
276
37743-37746
2001
Homo sapiens, Mus musculus
brenda
Black, R.A.
Tumor necrosis factor-alpha converting enzyme
Int. J. Biochem. Cell Biol.
34
1-5
2002
Homo sapiens, Mus musculus
brenda
Mohan, M.J.; Seaton, T.; Mitchell, J.; Howe, A.; Blackburn, K.; Burkhart, W.; Moyer, M.; Patel, I.; Waitt, G.M.; Becherer, J.D.; Moss, M.L.; Milla, M.E.
The tumor necrosis factor-alpha converting enzyme (TACE): A unique metalloproteinase with highly defined substrate selectivity
Biochemistry
41
9462-9469
2002
Homo sapiens, Mus musculus
brenda
Parkin, E.T.; Trew, A.; Christie, G.; Faller, A.; Mayer, R.; Turner, A.J.; Hooper, N.M.
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha
Biochemistry
41
4972-4981
2002
Chlorocebus aethiops, Homo sapiens, Mus musculus
brenda
Sunnarborg, S.W.; Hinkle, C.L.; Stevenson, M.; Russell, W.E.; Raska, C.S.; Peschon, J.J.; Castner, B.J.; Gerhart, M.J.; Paxton, R.J.; Black, R.A.; Lee, D.C.
Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability
J. Biol. Chem.
277
12838-12845
2002
Homo sapiens, Mus musculus
brenda
Xu, H.; Uysal, K.T.; Becherer, J.D.; Arner, P.; Hotamisligil, G.S.
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity
Diabetes
51
1876-1883
2002
Homo sapiens, Mus musculus
brenda
Canault, M.; Peiretti, F.; Kopp, F.; Bonardo, B.; Bonzi, M.; Coudeyre, J.; Alessi, M.; Juhan-Vague, I.; Nalbone, G.
The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: Possible contribution to elevated plasma levels of soluble TNF alpha receptors
Atherosclerosis
187
82-91
2006
Homo sapiens, Mus musculus
brenda
Bergmeier, W.; Piffath, C.L.; Cheng, G.; Dole, V.S.; Zhang, Y.; von Andrian, U.H.; Wagner, D.D.
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIba shedding from platelets in vitro and in vivo
Circ. Res.
95
677-683
2004
Homo sapiens, Mus musculus
brenda
Weskamp, G.; Schloendorff, J.; Lum, L.; Becherer, J.D.; Kim, T.; Saftig, P.; Hartmann, D.; Murphy, G.; Blobel, C.P.
Evidence for a critical role of the tumor necrosis factor a convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR)
J. Biol. Chem.
279
4241-4249
2004
Cricetulus griseus, Mus musculus
brenda
Lambert, D.W.; Yarski, M.; Warner, F.J.; Thornhill, P.; Parkin, E.T.; Smith, A.I.; Hooper, N.M.; Turner, A.J.
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
J. Biol. Chem.
280
30113-30119
2005
Mus musculus
brenda
Tsakadze, N.L.; Sithu, S.D.; Sen, U.; English, W.R.; Murphy, G.; DSouza, S.E.
Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1)
J. Biol. Chem.
281
3157-3164
2006
Mus musculus
brenda
Sahin, U.; Weskamp, G.; Kelly, K.; Zhou, H.; Higashiyama, S.; Peschon, J.; Hartmann, D.; Saftig, P.; Blobel, C.P.
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
J. Cell Biol.
164
769-779
2004
Mus musculus
brenda
Souza, D.G.; Ferreira, F.L.; Fagundes, C.T.; Amaral, F.A.; Vieira, A.T.; Lisboa, R.A.; Andrade, M.V.; Trifilieff, A.; Teixeira, M.M.
Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice
Eur. J. Pharmacol.
571
72-80
2007
Mus musculus
brenda
Zhan, M.; Jin, B.; Chen, S.; Reecy, J.M.; Li, Y.
TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38 MAPK and myogenesis
J. Cell Sci.
120
692-701
2007
Mus musculus
brenda
Tanabe, Y.; Kasahara, T.; Momoi, T.; Fujita, E.
Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases
Neurosci. Lett.
444
16-21
2008
Mus musculus
brenda
Bozkulak, E.C.; Weinmaster, G.
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
Mol. Cell. Biol.
29
5679-5695
2009
Mus musculus
brenda
Killock, D.J.; Ivetic, A.
The cytoplasmic domains of TNFalpha-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding
Biochem. J.
428
293-304
2010
Mus musculus
brenda
Li, X.; Yan, Y.; Huang, W.; Yang, Y.
The study of the inhibition of the recombinant TACE prodomain to endotoxemia in mice
Int. J. Mol. Sci.
10
5442-5454
2009
Mus musculus
brenda
Wang, Y.; Zhang, A.C.; Ni, Z.; Herrera, A.; Walcheck, B.
ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis
J. Immunol.
184
4447-4454
2010
Homo sapiens, Mus musculus
brenda
Pradines, E.; Loubet, D.; Mouillet-Richard, S.; Manivet, P.; Launay, J.M.; Kellermann, O.; Schneider, B.
Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells
J. Neurochem.
110
912-923
2009
Mus musculus
brenda
Liu, Q.; Zhang, J.; Tran, H.; Verbeek, M.; Reiss, K.; Estus, S.; Bu, G.
LRP1 shedding in human brain: Roles of ADAM10 and ADAM17
Mol. Neurodegener.
4
17
2009
Mus musculus
brenda
Battaglia-Hsu, S.F.; Akchiche, N.; Noel, N.; Alberto, J.M.; Jeannesson, E.; Orozco-Barrios, C.E.; Martinez-Fong, D.; Daval, J.L.; Gueant, J.L.
Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE
Proc. Natl. Acad. Sci. USA
106
21930-21935
2009
Mus musculus
brenda
Chalaris, A.; Rose-John, S.
Proteases. ADAM 17: Molecular switch between inflammation and regeneration
BIOspektrum
17
506-509
2011
Mus musculus
-
brenda
Garbers, C.; Jaenner, N.; Chalaris, A.; Moss, M.L.; Floss, D.M.; Meyer, D.; Koch-Nolte, F.; Rose-John, S.; Scheller, J.
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
J. Biol. Chem.
286
14804-14811
2011
Mus musculus
brenda
Chalaris, A.; Adam, N.; Sina, C.; Rosenstiel, P.; Lehmann-Koch, J.; Schirmacher, P.; Hartmann, D.; Cichy, J.; Gavrilova, O.; Schreiber, S.; Jostock, T.; Matthews, V.; Haesler, R.; Becker, C.; Neurath, M.; Reiss, K.; Saftig, P.; Scheller, J.; Rose-John, S.
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
J. Exp. Med.
207
1617-1624
2010
Mus musculus
brenda
Scheller, J.; Chalaris, A.; Garbers, C.; Rose-John, S.
ADAM17: A molecular switch to control inflammation and tissue regeneration
Trends Immunol.
32
380-387
2011
Mus musculus
brenda
Lorenzen, I.; Lokau, J.; Dsterhft, S.; Trad, A.; Garbers, C.; Scheller, J.; Rose-John, S.; Grtzinger, J.
The membrane-proximal domain of A disintegrin and metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II
FEBS Lett.
586
1093-1100
2012
Mus musculus (Q9Z0F8)
brenda
Marczynska, J.; Ozga, A.; Wlodarczyk, A.; Majchrzak-Gorecka, M.; Kulig, P.; Banas, M.; Michalczyk-Wetula, D.; Majewski, P.; Hutloff, A.; Schwarz, J.; Chalaris, A.; Scheller, J.; Rose-John, S.; Cichy, J.
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses
J. Immunol.
193
2753-2763
2014
Mus musculus (Q9Z0F8)
brenda
Patel, V.B.; Clarke, N.; Wang, Z.; Fan, D.; Parajuli, N.; Basu, R.; Putko, B.; Kassiri, Z.; Turner, A.J.; Oudit, G.Y.
Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS
J. Mol. Cell. Cardiol.
66
167-176
2014
Homo sapiens (P78536), Mus musculus (Q9Z0F8)
brenda
DeBerge, M.; Ely, K.; Cheng, G.; Enelow, R.
ADAM17-mediated processing of TNF-alpha expressed by antiviral effector CD8+ T cells is required for severe T-cell-mediated lung injury
PLoS ONE
8
e79340
2013
Mus musculus (Q9Z0F8)
brenda
Chapnick, D.; Bunker, E.; Liu, X.
A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation
Sci. Signal.
8
365
2015
Mus musculus (Q9Z0F8)
brenda
Xu, J.; Sriramula, S.; Lazartigues, E.
Excessive glutamate stimulation impairs ACE2 activity through ADAM17-mediated shedding in cultured cortical neurons
Cell. Mol. Neurobiol.
38
1235-1243
2018
Mus musculus
brenda
Shen, M.; Hu, M.; Fedak, P.; Oudit, G.; Kassiri, Z.
Cell-specific functions of ADAM17 regulate the progression of thoracic aortic aneurysm
Circ. Res.
123
372-388
2018
Mus musculus, Homo sapiens (P78536), Homo sapiens
brenda
Yoneyama, T.; Gorry, M.; Miller, M.; Gaither-Davis, A.; Lin, Y.; Moss, M.; Griffith, L.; Lauffenburger, D.; Stabile, L.; Herman, J.; Vujanovic, N.
Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates
J. Cancer
8
3916-3932
2017
Mus musculus, Homo sapiens (P78536)
brenda