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Literature summary for 3.4.24.86 extracted from
- The tumor necrosis factor-alpha converting enzyme (2000), Handbook of Experimental Pharmacology, (von der Helm, K. ; Korant, B. C. ; Cheronis, J. C. eds. ), 140, 235-258.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | TNF-alpha thought to be a selective anti-tumor agent and a contributor to cachexia in cancer patients, clinical trials for cancer | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
| recombinant TACE expressed in insect cells | Sus scrofa |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BB 1101 | - |
Homo sapiens |  |
| BB 1433 | - |
Homo sapiens | |
| BB 16 | - |
Homo sapiens | |
| BB 2116 | - |
Homo sapiens | |
| BB 2516 | - |
Homo sapiens | |
| BB 94 | - |
Homo sapiens | |
| BB 94 | - |
Mus musculus | |
| CGS 27023 | - |
Homo sapiens | |
| CT 572 | - |
Homo sapiens | |
| GI 129471 | - |
Homo sapiens | |
| GM 6001 | - |
Homo sapiens | |
| GW 3333 | - |
Homo sapiens | |
| GW9471 | - |
Homo sapiens | |
| GW9471 | - |
Mus musculus | |
| Hydroxamate | - |
Homo sapiens | |
| Hydroxamate | - |
Mus musculus | |
| KB-R7785 | - |
Homo sapiens | |
| peptidomimetic hydroxamate | - |
Homo sapiens | |
| Ro 31-9790 | - |
Homo sapiens | |
| SC 903 | - |
Homo sapiens | |
| SE 205 | - |
Homo sapiens | |
| succinyl hydroxamate | - |
Homo sapiens | |
| sulfonamide hydroxamate | - |
Homo sapiens | |
| TAPI | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | cytoplasmic tail | Mus musculus | 5737 | - |
| cytoplasm | cytoplasmic tail | Homo sapiens | 5737 | - |
| membrane | membrane-bound | Mus musculus | 16020 | - |
| membrane | membrane-bound | Homo sapiens | 16020 | - |
| membrane | membrane-bound | Sus scrofa | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| monocyte | - |
Mus musculus | - |
| monocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Sus scrofa | ? | - |
? | |
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