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Literature summary for 3.4.24.86 extracted from

  • Reddy, P.; Slack, J.L.; Davis, R.; Cerretti, D.P.; Kozlosky, C.J.; Blanton, R.A.; Shows, D.; Peschon, J.J.; Black, R.A.
    Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme (2000), J. Biol. Chem., 275, 14608-14614.
    View publication on PubMed
Search for more literature for 3.4.24.86

Cloned(Commentary)

Cloned (Comment) Organism
reconstitution of TNF shedding in TACE-deficient cells by TACE cDNA transfection Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
membrane membrane-bound Mus musculus 16020
-
membrane membrane-bound Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloprotease Mus musculus
Zn2+ zinc metalloprotease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 accession number for cytoplasmic domain coding sequence
-
Homo sapiens P78536
-
-
Mus musculus
-
 mouse
-
Mus musculus
-
 wild-type EC-4
-
Mus musculus EC-4
-
 wild-type EC-4
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-
fibroblast
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
interleukin (IL)-1R-II + H2O
-
 Mus musculus ?
-
 ?
interleukin (IL)-1R-II + H2O
-
 Homo sapiens ?
-
 ?
L-selectin + H2O
-
 Mus musculus ?
-
 ?
L-selectin + H2O
-
 Homo sapiens ?
-
 ?
additional information
-
 Mus musculus ?
-
 ?
additional information TACE is a multidomain, type I transmembrane protein, contains a pro-domain which is removed by proteolysis to generate the active enzyme and a zinc-dependent metalloprotease catalytic domain, TACE cleaves peptides containing the sequence of the processing site at the physiolocically relevant peptide bond Homo sapiens ?
-
 ?
additional information
-
 Mus musculus EC-4 ?
-
 ?
p55 TNFR1 + H2O
-
 Mus musculus ?
-
 ?
p55 TNFR1 + H2O
-
 Homo sapiens ?
-
 ?
p55 TNFR1 + H2O
-
 Mus musculus EC-4 ?
-
 ?
p75 tumour necrosis factor receptor + H2O shedding Mus musculus ?
-
 ?
p75 tumour necrosis factor receptor + H2O shedding Homo sapiens ?
-
 ?
p75 tumour necrosis factor receptor + H2O shedding Mus musculus EC-4 ?
-
 ?
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
proTNF-alpha + H2O
-
 Mus musculus EC-4 soluble TNF-alpha
-
 ?
transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?
transforming growth factor alpha + H2O
-
 Mus musculus EC-4 ?
-
 ?

Synonyms

Synonyms Comment Organism
human TACE B
-
 Homo sapiens