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Literature summary for 3.4.24.86 extracted from

  • Battaglia-Hsu, S.F.; Akchiche, N.; Noel, N.; Alberto, J.M.; Jeannesson, E.; Orozco-Barrios, C.E.; Martinez-Fong, D.; Daval, J.L.; Gueant, J.L.
    Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE (2009), Proc. Natl. Acad. Sci. USA, 106, 21930-21935.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
N1E-115 cell neuroblastoma cell line Mus musculus
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Expression

Organism Comment Expression
Mus musculus in proliferating cells which are stably transfected to impose the anchorage of a chimeric B12-binding protein, transcobalamin-oleosin TO, to the intracellular membrane, a 2-fold increase of p75NTR-regulated intramembraneous proteolysis is observed that is associated with an increased expression of enzymes Adam-10 and Adam-17 up

General Information

General Information Comment Organism
physiological function vitamin B12 cellular deficiency produces a slower proliferation and a speedier differentiation of neuroblastoma cells through interacting signaling pathways that are related with increased expression of phophatase 2A, pro-nerve growth factor and TACE Mus musculus