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Literature summary for 3.4.24.86 extracted from
- Intracellular maturation and localization of the tumor necrosis factor alpha convertase (TACE) (2000), Biochem. J., 347, 131-138.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol ester | - |
Mus musculus |  |
| phorbol ester | - |
Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA fragment coding for the prodomain of human TACE, expressed and purified from a baculoviral expression system | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Chlorocebus aethiops | |
| 1,10-phenanthroline | - |
Homo sapiens | |
| 1,10-phenanthroline | - |
Mus musculus | |
| BB 94 | - |
Chlorocebus aethiops | |
| BB 94 | - |
Homo sapiens | |
| BB 94 | - |
Mus musculus | |
| EndoH | full-length TACE is sensitive to EndoH, mature TACE is resistant | Chlorocebus aethiops | |
| EndoH | full-length TACE is sensitive to EndoH, mature TACE is resistant | Homo sapiens | |
| EndoH | full-length TACE is sensitive to EndoH, mature TACE is resistant | Mus musculus | |
| Hydroxamate | - |
Chlorocebus aethiops | |
| Hydroxamate | - |
Homo sapiens | |
| Hydroxamate | - |
Mus musculus | |
| TACE-pro domain | pro domain is an inhibitor of the catalytic domain | Homo sapiens | |
| TACE-pro domain | - |
Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Mus musculus | 9986 | - |
| cell surface | - |
Homo sapiens | 9986 | - |
| cytoplasm | cytoplasmic tail | Mus musculus | 5737 | - |
| cytoplasm | cytoplasmic tail | Homo sapiens | 5737 | - |
| cytoplasm | cytoplasmic tail | Chlorocebus aethiops | 5737 | - |
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Chlorocebus aethiops | 5783 | - |
| Golgi apparatus | proximal Golgi | Mus musculus | 5794 | - |
| Golgi apparatus | proximal Golgi | Homo sapiens | 5794 | - |
| Golgi apparatus | proximal Golgi | Chlorocebus aethiops | 5794 | - |
| membrane | - |
Chlorocebus aethiops | 16020 | - |
| membrane | membrane-bound | Mus musculus | 16020 | - |
| membrane | membrane-bound | Homo sapiens | 16020 | - |
| perinuclear space | - |
Mus musculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloprotease | Mus musculus | |
| Zn2+ | zinc metalloprotease | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
migrates as a 80 kDa protein under non-reducing conditions, immunoprecipitation | Mus musculus |
| 80000 | - |
migrates as a 80 kDa protein under non-reducing conditions, immunoprecipitation | Homo sapiens |
| 80000 | - |
migrates as a 80 kDa protein under non-reducing conditions, immunoprecipitation | Chlorocebus aethiops |
| 100000 | - |
100 kDa reduced form represents mature TACE lacking the prodomain, immunoprecipitation | Mus musculus |
| 100000 | - |
100 kDa reduced form represents mature TACE lacking the prodomain, immunoprecipitation | Homo sapiens |
| 120000 | - |
full length form of TACE migrates as a 120 kDa protein under reducing conditions, immunoprecipitation | Mus musculus |
| 120000 | - |
full length form of TACE migrates as a 120 kDa protein under reducing conditions, immunoprecipitation | Homo sapiens |
| 120000 | - |
full length form of TACE migrates as a 120 kDa protein under reducing conditions, immunoprecipitation | Chlorocebus aethiops |
| 160000 | - |
identified with prodomain antibody in COS-7 membrane preparations | Chlorocebus aethiops |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlorocebus aethiops | - |
african green monkey, COS-7, an SV40 transformed kidney cell line | - |
| Homo sapiens | - |
human monocytic cell line THP-1 | - |
| Mus musculus | - |
mouse | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Chlorocebus aethiops | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
| beta-amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
| L-selectin + H2O | - |
Mus musculus | ? | - |
? | |
| L-selectin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | - |
Homo sapiens | ? | - |
? | |
| additional information | angiotensin converting enzyme is not cleaved by TACE | Mus musculus | ? | - |
? | |
| p75 tumour necrosis factor receptor + H2O | - |
Mus musculus | ? | - |
? | |
| p75 tumour necrosis factor receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Chlorocebus aethiops | ? | - |
? | |
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Release 2023.1 (January 2023)
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