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Literature summary for 3.4.24.86 extracted from
- Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding (2011), J. Biol. Chem., 286, 14804-14811.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GW280264X | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | in mice, the interleukin-6 receptor is not a target of ADAM17 | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloprotease 17 | - |
Mus musculus |
| ADAM17 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAM17is the main sheddase of interleukin-6 receptor to induce interleukin-6 trans-signaling | Mus musculus |
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Release 2023.1 (January 2023)
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