Cloned (Comment) | Organism |
---|---|
cDNA encoding TACE, full-length human TACE, inefficiently expressed in insect cells, baculovirus particles in Sf9 cell line from Spodoptera frugiperda | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GW1988 | - |
Homo sapiens | |
GW9471 | - |
Homo sapiens | |
GW9471 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | cytoplasmic tail | Mus musculus | 5737 | - |
cytoplasm | cytoplasmic tail | Homo sapiens | 5737 | - |
membrane | - |
Mus musculus | 16020 | - |
membrane | microsomal membrane, transmembrane domain | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloprotease | Mus musculus | |
Zn2+ | zinc metalloprotease | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | 100000 | sucrose density gradient centrifugation | Mus musculus |
85000 | - |
glycerol gradient, gel filtration | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Homo sapiens | - |
MonoMac 6 cells | - |
Mus musculus | - |
- |
- |
Mus musculus | - |
mouse | - |
Mus musculus C3H/HEN | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | - |
Mus musculus | - |
monocyte | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
proTNF-alpha + H2O | - |
Mus musculus C3H/HEN | soluble TNF-alpha | - |
? | |
transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
transforming growth factor alpha + H2O | - |
Mus musculus C3H/HEN | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H-TACE | - |
Homo sapiens |