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Information on EC 6.2.1.52 - L-firefly luciferin-CoA ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.52 L-firefly luciferin-CoA ligase
IUBMB Comments
This is an alternative activity of the firefly luciferase (EC 1.13.12.7), which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate. The D-isomer can act as a substrate for the CoA---ligase activity in vitro only under low oxygen conditions that are not found in vivo. The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
firefly luciferase, long-chain fattyacyl-CoA synthetase, Luc, LUC-G, LUC-H, luciferyl-CoA synthetase, protoluciferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA
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