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Information on EC 4.2.1.134 - very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
IUBMB Comments
This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
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Word Map
  • 4.2.1.134
  • dopaminergic
  • early-onset
  • mitophagy
  • proteasome
  • nigra
  • substantia
  • dopamine
  • alpha-synuclein
  • parkin-mediated
  • ubiquitin-like
  • idiopathic
  • ubiquitin-protein
  • adaptor
  • proto-oncogene
  • pten-induced
  • depolarization
  • nigrostriatal
  • ligases
  • sh-sy5y
  • midbrain
  • autosomal-recessive
  • polyubiquitination
  • compacta
  • ubiquitin-proteasome
  • tyrosine-phosphorylated
  • pd-associated
  • levodopa
  • b-lineage
  • e3-ubiquitin
  • pd-linked
  • dystonia
  • young-onset
  • sh2
  • pd-related
  • ring-type
  • dyskinesia
  • ubiquitin-ligase
  • mitofusins
  • rbr
  • juvenile-onset
  • aggresomes
  • casitas
  • synphilin-1
  • biotechnology
The enzyme appears in viruses and cellular organisms
Synonyms
hacd1, 3-hydroxyacyl-coa dehydratase, hacd4, pasticcino2, hacd2, hacd3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H2O
show the reaction diagram
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