Literature summary for 4.2.1.134 extracted from

Bach, L.; Michaelson, L.V.; Haslam, R.; Bellec, Y.; Gissot, L.; Marion, J.; Da Costa, M.; Boutin, J.P.; Miquel, M.; Tellier, F.; Domergue, F.; Markham, J.E.; Beaudoin, F.; Napier, J.A.; Faure, J.D.
The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development (2008), Proc. Natl. Acad. Sci. USA, 105, 14727-14731.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Nicotiana benthamiana and Arabidopsis thaliana epidermal cells	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	the enzyme is specifically associated in the endoplasmic reticulum with the enoyl-CoA reductase CER10	Arabidopsis thaliana	5783	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	ecotype Col-0	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxyacyl-CoA	-	Arabidopsis thaliana	2,3-trans-enoyl-CoA + H2O	-	?

Synonyms

Synonyms	Comment	Organism
fatty acyl-CoA dehydratase	-	Arabidopsis thaliana
PAS2	-	Arabidopsis thaliana
PASTICCINO2	-	Arabidopsis thaliana
very-long-chain hydroxy fatty acyl-CoA dehydratase	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
malfunction	complete loss of enzyme function is embryo lethal. The pas2-1 mutant is characterized by a general reduction of very-long-chain fatty acid pools in seed storage triacylglycerols, cuticular waxes, and complex sphingolipids	Arabidopsis thaliana
physiological function	the enzyme is essential and limiting for Arabidopsis development. Enzyme-derived very-long-chain fatty acid homeostasis is required for specific developmental processes. The enzyme is involved in 3-hydroxy acyl-coa dehydration during very-long-chain fatty acid elongation	Arabidopsis thaliana

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Release 2023.1 (January 2023)