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Literature summary for 4.2.1.134 extracted from

  • Liang, Y.; Liu, Y.; Tang, J.; Ma, J.; Cheng, J.; Daroch, M.
    Transcriptomic profiling and gene disruption revealed that two genes related to Pufas/DHA biosynthesis may be essential for cell growth of Aurantiochytrium sp. (2018), Mar. Drugs, 16, 310-324 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
biotechnology the enzyme is a potential target for biotechnological optimization of the production of docosahexenoic acid (DHA) in the Aurantiochytrium sp. thraustochytrid strain PKUSW7 Aurantiochytrium sp.

Cloned(Commentary)

Cloned (Comment) Organism
gene PH, de novo assembly and functional annotation of Aurantiochytrium transcriptome and library screening, sequence comparisons, quantitative real-time PCR expression analysis, gene PH expression pattern analysis Aurantiochytrium sp.

Protein Variants

Protein Variants Comment Organism
additional information construction of an enzyme deletion mutant DELTAPH, phenotype, overview Aurantiochytrium sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Aurantiochytrium sp. the very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase catalyzes fatty acid elongation from C20:5 to C22:5 ?
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?
additional information Aurantiochytrium sp. PKUSW7 the very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase catalyzes fatty acid elongation from C20:5 to C22:5 ?
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?

Organism

Organism UniProt Comment Textmining
Aurantiochytrium sp. A0A345DF76
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Aurantiochytrium sp. PKUSW7 A0A345DF76
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase catalyzes fatty acid elongation from C20:5 to C22:5 Aurantiochytrium sp. ?
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?
additional information the very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase catalyzes fatty acid elongation from C20:5 to C22:5 Aurantiochytrium sp. PKUSW7 ?
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?

Expression

Organism Comment Expression
Aurantiochytrium sp. significantly lower expression levels of the gene PH when salinity decreases to less than 100% seawater down

General Information

General Information Comment Organism
metabolism the enzyme is involved in the fatty acid synthesis, pathway overview. De novo assembly and functional annotation of Aurantiochytrium transcriptome and library screening to determinthe enzymes important for docosahexenoic acid biosynthesis, overview Aurantiochytrium sp.
physiological function the enzyme is involved in fatty acid synthesis. The very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase catalyzes fatty acid elongation from C20:5 to C22:5. The enzyme activity is correlated to the docosahexenoic acid (DHA) content, reduction of enzyme expression leads to reduced DHA Aurantiochytrium sp.