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Information on EC 1.14.14.20 - phenol 2-monooxygenase (FADH2)

for references in articles please use BRENDA:EC1.14.14.20
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IUBMB Comments
The enzyme catalyses the ortho-hydroxylation of simple phenols into the corresponding catechols. It accepts 4-methylphenol, 4-chlorophenol, and 4-fluorophenol as well as 4-nitrophenol, 3-nitrophenol, and resorcinol . The enzyme is part of a two-component system that also includes an NADH-dependent flavin reductase. It is strictly dependent on FADH2 and does not accept FMNH2 [1,3]. cf. EC 1.14.13.7, phenol 2-monooxygenase (NADPH).
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
phea2, phea1, flavin reductase phea2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phenol + FADH2 + O2 = catechol + FAD + H2O
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