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Information on EC 1.1.1.236 - tropinone reductase II

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IUBMB Comments
This enzyme along with EC 1.1.1.206, tropine dehydrogenase, represents a branch point in tropane alkaloid metabolism . Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines . Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
tr-ii, tropinone reductase ii, dntr2, pseudotropine-forming tropinone reductase, tropinone reductase-ii, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
pseudotropine + NADP+ = tropinone + NADPH + H+
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