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Literature summary for 1.1.1.236 extracted from

  • Boswell, H.D.; Drไger, B.; McLauchlan W.R.; Portsteffen, A.; Robins D.J.; Robins R.J.; Walton, N.J.
    Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura (1999), Phytochemistry, 52, 871-878.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
tropinone
-
Datura stramonium
0.16
-
tropinone
-
Brugmansia x candida
0.25
-
N-ethylnortropinone
-
Datura stramonium
0.67
-
N-(2-fluoroethyl)nortropinone
-
Datura stramonium
1.4
-
N-methylpiperid-4-one
-
Datura stramonium
2.8
-
4-methylcyclohexanone
-
Datura stramonium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tropinone + NADPH + H+ Datura stramonium
-
pseudotropine + NADP+
-
?
tropinone + NADPH + H+ Hyoscyamus niger
-
pseudotropine + NADP+
-
?
tropinone + NADPH + H+ Brugmansia x candida
-
pseudotropine + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Brugmansia x candida
-
x aurea hybrid
-
Datura stramonium
-
D15/5
-
Datura stramonium cv. D15/5
-
D15/5
-
Hyoscyamus niger
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Datura stramonium
-
Brugmansia x candida

Source Tissue

Source Tissue Comment Organism Textmining
root
-
Datura stramonium
-
root
-
Hyoscyamus niger
-
root
-
Brugmansia x candida
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(2-fluoroethyl)nortropinone + NADPH
-
Datura stramonium ? + NADP+
-
?
N-ethylnortropinone + NADPH
-
Datura stramonium ? + NADP+
-
?
N-iso-propylnortropinone + NADPH
-
Datura stramonium ? + NADP+
-
?
N-methyl-4-piperidone + NADPH
-
Datura stramonium N-methylpiperidin-4-ol + NADP+
-
?
N-methyl-4-piperidone + NADPH
-
Hyoscyamus niger N-methylpiperidin-4-ol + NADP+
-
?
tropinone + NADPH + H+
-
Datura stramonium pseudotropine + NADP+
-
?
tropinone + NADPH + H+
-
Hyoscyamus niger pseudotropine + NADP+
-
?
tropinone + NADPH + H+
-
Brugmansia x candida pseudotropine + NADP+
-
?