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EC 3.2.2.6 Details

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EC number

3.2.2.6

Accepted name

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Reaction

NAD⁺ + H₂O = ADP-D-ribose + nicotinamide (overall reaction);;(1a) NAD⁺ = cyclic ADP-ribose + nicotinamide;;(1b) cyclic ADP-ribose + H₂O = ADP-D-ribose

Other name(s)

NAD⁺ nucleosidase, NADase (ambiguous), DPNase (ambiguous), DPN hydrolase (ambiguous), NAD hydrolase (ambiguous), nicotinamide adenine dinucleotide nucleosidase (ambiguous), NAD glycohydrolase (misleading), NAD nucleosidase (ambiguous), nicotinamide adenine dinucleotide glycohydrolase (misleading), CD38 (gene name), BST1 (gene name)

Systematic name

NAD⁺ glycohydrolase (cyclic ADP-ribose-forming)

CAS registry number

9032-65-9

Comment

This multiunctional enzyme acts on NAD⁺, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca²⁺ stores and activate Ca²⁺ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase. It is also able to act on β-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD⁺ glycohydrolase.

History

created 1961, modified 2004, modified 2014, modified 2018

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.1 purine nucleosidase

3.2.2.2 inosine nucleosidase

3.2.2.3 uridine nucleosidase

3.2.2.4 AMP nucleosidase

3.2.2.5 NAD⁺ glycohydrolase

3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

3.2.2.7 adenosine nucleosidase

3.2.2.8 ribosylpyrimidine nucleosidase

3.2.2.9 adenosylhomocysteine nucleosidase

3.2.2.10 pyrimidine-5′-nucleotide nucleosidase

3.2.2.11 β-aspartyl-N-acetylglucosaminidase

3.2.2.12 inosinate nucleosidase

3.2.2.13 1-methyladenosine nucleosidase

3.2.2.14 NMN nucleosidase

3.2.2.15 DNA-deoxyinosine glycosylase

3.2.2.16 methylthioadenosine nucleosidase

3.2.2.17 deoxyribodipyrimidine endonucleosidase

3.2.2.18 created 1984, deleted 1989

3.2.2.19 [protein ADP-ribosylarginine] hydrolase

3.2.2.20 DNA-3-methyladenine glycosylase I

3.2.2.21 DNA-3-methyladenine glycosylase II

3.2.2.22 rRNA N-glycosylase

3.2.2.23 DNA-formamidopyrimidine glycosylase

3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase

3.2.2.25 N-methyl nucleosidase

3.2.2.26 futalosine hydrolase

3.2.2.27 uracil-DNA glycosylase

3.2.2.28 double-stranded uracil-DNA glycosylase

3.2.2.29 thymine-DNA glycosylase

3.2.2.30 aminodeoxyfutalosine nucleosidase

3.2.2.31 adenine glycosylase

3.2.3 Hydrolysing S-glycosyl compounds (deleted sub-subclass)

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

4 Lyases

5 Isomerases

6 Ligases

6.1 Forming carbon-oxygen bonds

6.2 Forming carbon-sulfur bonds

6.3 Forming carbon-nitrogen bonds

6.4 Forming carbon-carbon bonds

6.5 Forming phosphoric-ester bonds

6.6 Forming nitrogen—metal bonds

6.7 Forming nitrogen-nitrogen bonds

7 Translocases