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EC 3.2.2.31 Details
EC number
3.2.2.31
Accepted name
adenine glycosylase
Reaction
Hydrolyses free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
Other name(s)
mutY (gene name), A/G-specific adenine glycosylase
Systematic name
adenine-DNA deoxyribohydrolase (adenine-releasing)
Comment
The enzyme serves as a mismatch repair enzyme that works to correct 7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO) lesions in DNA. The enzyme excises the adenine of the mispair, producing an apurinic site sensitive to AP endonuclease activity. After removing the undamaged adenine the enzyme remains bound to the site to prevent EC 3.2.2.23 (MutM) from removing the GO lesion, which could lead to a double strand break. In vitro the enzyme is also active with adenine:guanine, adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs, removing the adenine in all cases.
History
created 2018
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.2 Hydrolysing N-glycosyl compounds
3.2.2.1 purine nucleosidase
3.2.2.2 inosine nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.4 AMP nucleosidase
3.2.2.5 NAD+ glycohydrolase
3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase
3.2.2.10 pyrimidine-5′-nucleotide nucleosidase
3.2.2.11 β-aspartyl-N-acetylglucosaminidase
3.2.2.12 inosinate nucleosidase
3.2.2.13 1-methyladenosine nucleosidase
3.2.2.14 NMN nucleosidase
3.2.2.15 DNA-deoxyinosine glycosylase
3.2.2.16 methylthioadenosine nucleosidase
3.2.2.17 deoxyribodipyrimidine endonucleosidase
3.2.2.18 created 1984, deleted 1989
3.2.2.19 [protein ADP-ribosylarginine] hydrolase
3.2.2.20 DNA-3-methyladenine glycosylase I
3.2.2.21 DNA-3-methyladenine glycosylase II
3.2.2.22 rRNA N-glycosylase
3.2.2.23 DNA-formamidopyrimidine glycosylase
3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase
3.2.2.25 N-methyl nucleosidase
3.2.2.26 futalosine hydrolase
3.2.2.27 uracil-DNA glycosylase
3.2.2.28 double-stranded uracil-DNA glycosylase
3.2.2.29 thymine-DNA glycosylase
3.2.2.30 aminodeoxyfutalosine nucleosidase
3.2.2.31 adenine glycosylase
3.2.3 Hydrolysing S-glycosyl compounds (deleted sub-subclass)
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases