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EC 3.2.2.5 Details
EC number
3.2.2.5
Accepted name
NAD+ glycohydrolase
Reaction
NAD+ + H2O = ADP-D-ribose + nicotinamide
Other name(s)
NAD glycohydrolase, nicotinamide adenine dinucleotide glycohydrolase, β-NAD+ glycohydrolase, DPNase (ambiguous), NAD hydrolase (ambiguous), diphosphopyridine nucleosidase (ambiguous), nicotinamide adenine dinucleotide nucleosidase (ambiguous), NAD nucleosidase (ambiguous), DPN hydrolase (ambiguous), NADase (ambiguous), nga (gene name), NAD+ nucleosidase
Systematic name
NAD+ glycohydrolase
CAS registry number
9025-46-1
Comment
This enzyme catalyses the hydrolysis of NAD+, without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase). The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis. The enzyme from the venom of the snake Agkistrodon acutus also catalyses EC 3.6.1.5, apyrase [3].
History
created 1961, modified 2013
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.2 Hydrolysing N-glycosyl compounds
3.2.2.1 purine nucleosidase
3.2.2.2 inosine nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.4 AMP nucleosidase
3.2.2.5 NAD+ glycohydrolase
3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase
3.2.2.10 pyrimidine-5′-nucleotide nucleosidase
3.2.2.11 β-aspartyl-N-acetylglucosaminidase
3.2.2.12 inosinate nucleosidase
3.2.2.13 1-methyladenosine nucleosidase
3.2.2.14 NMN nucleosidase
3.2.2.15 DNA-deoxyinosine glycosylase
3.2.2.16 methylthioadenosine nucleosidase
3.2.2.17 deoxyribodipyrimidine endonucleosidase
3.2.2.18 created 1984, deleted 1989
3.2.2.19 [protein ADP-ribosylarginine] hydrolase
3.2.2.20 DNA-3-methyladenine glycosylase I
3.2.2.21 DNA-3-methyladenine glycosylase II
3.2.2.22 rRNA N-glycosylase
3.2.2.23 DNA-formamidopyrimidine glycosylase
3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase
3.2.2.25 N-methyl nucleosidase
3.2.2.26 futalosine hydrolase
3.2.2.27 uracil-DNA glycosylase
3.2.2.28 double-stranded uracil-DNA glycosylase
3.2.2.29 thymine-DNA glycosylase
3.2.2.30 aminodeoxyfutalosine nucleosidase
3.2.2.31 adenine glycosylase
3.2.3 Hydrolysing S-glycosyl compounds (deleted sub-subclass)
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases