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Information on EC 3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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EC Tree
     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
IUBMB Comments
This multiunctional enzyme catalyses both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. cf. EC 3.2.2.5, NAD+ glycohydrolase.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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Synonyms
adp-ribosyl cyclase, adpr cyclase, nad(p)ase, nad(p)-glycohydrolase, bcd38, nad(p)+ glycohydrolase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
cyclic ADP-ribose + H2O = ADP-D-ribose
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(1b)
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NAD+ + H2O = ADP-D-ribose + nicotinamide
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NAD+ = cyclic ADP-ribose + nicotinamide
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(1a)
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