2.7.1.40: pyruvate kinase

This is an abbreviated version!
For detailed information about pyruvate kinase, go to the full flat file.

Reaction

Synonyms

ATP/pyruvate O'-phosphotransferase, ATP:pyruvate 2-O-phosphotransferase, CPK, CPK1, cPK2, cPK3, cPK4, cPK5, CTHBP, cytosolic pyruvate kinase, cytosolic thyroid hormone binding protein, EHI_098420, EhPK, EhPyk, erythroid (R-type) pyruvate kinase, fluorokinase, hL-PYK, hLPYK, hPKM2, K+-dependent PK, K+-independent PK, kinase, fluoro- (phosphorylating), kinase, pyruvate (phosphorylating), L-PK , L-PYK, liver PK, liver pyruvate kinase, M1-PK, M1-PYK, M2 pyruvate kinase, M2 type phosphoenolpyruvate kinase, M2-PK, M2-pyruvate kinase, M2-type pyruvate kinase, M2PK, mPKM2, MRSA PK, muscle PK, NCgl2008, NCgl2809, PAE0819, PfPYK, pfPyrK, phosphoenol transphosphorylase, phosphoenolpyruvate kinase, phosphoenolpyruvate: ADP phosphotransferase, PK-alphabeta1, PK-alphabeta2, PK-M1, PK-M2, PK-R, PK-S, PK1, PK3, PKC, PKC1, PKL, Pklr, PKM1, PKM2, PKp, ProTalphaK, PYK, PYK-I, Pyk1, Pyk2, PykA, PykF, PyKII, pyruvate kinase, pyruvate kinase 1, pyruvate kinase isoenzyme M2, pyruvate kinase isoform M2, pyruvate kinase isoforms 2, pyruvate kinase isozyme M1, pyruvate kinase isozyme type M2, pyruvate kinase M1, pyruvate kinase M2, pyruvate kinase M2 isoform, pyruvate kinase muscle isoform 2, pyruvate kinase muscle isozyme, pyruvate kinase type M2, pyruvate kinase type-II, pyruvate phosphotransferase, pyruvic kinase, R-type pyruvate kinase, R-type/L-type pyruvate kinase, red cell/liver pyruvate kinase, rM1-PYK, RMPK, RPK, Rv1617, SSO0981, TbrPYK, TCIL3000_10_12020, TcoPYK, THBP1, TuM2-PK, tumor cell specific pyruvate kinase isozyme M2, tumour M2-PK, tumour M2-pyruvate kinase, VcIIPK, VcIPK, VC_0485, VC_2008, VEG17, vegetative protein 17, vesicle-associated pyruvate kinase, YPK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.40 pyruvate kinase

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Results	in table
393	Activating Compound
60760	AA Sequence
26	Application
1	CAS Registry Number
72	Cloned(Commentary)
133	Cofactor
27	Crystallization (Commentary)
7566	Disease/ Diagnostics
19	Expression
160	General Information
22	General Stability
212	IC50 Value
649	Inhibitors
38	kcat/KM [mM/s]
31	Ki Value [mM]
354	KM Value [mM]
47	Localization
359	Metals/Ions
219	Molecular Weight [Da]
132	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
816	Organism
27	Pathway
673	PDB ID
95	pH Optimum
23	pH Range
5	pH Stability
25	pI Value
17	Posttranslational Modification
144	Protein Variants
166	Purification (Commentary)
23	Reaction
1	Reaction Type
381	Reference
4	Renatured (Commentary)
383	Source Tissue
111	Specific Activity [micromol/min/mg]
34	Storage Stability
491	Substrates and Products (Substrate)
194	Subunits
312	Synonyms
1	Systematic Name
75	Temperature Optimum [°C]
2	Temperature Range [°C]
50	Temperature Stability [°C]
57	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 2.7.1.40 - pyruvate kinase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acylation

Urocitellus richardsonii

-

pyruvate kinase (PK) from the torpid condition is shown to possess nearly twofold acetyl content as compared to control PK

761891

alkylation

2 entries

phosphoprotein

11 entries

sumoylation

Homo sapiens

-

PIAS3 slightly enhances M2-PK sumoylation

709228

additional information

2 entries

alkylation

Trachemys scripta elegans

Q9I8C5, Q9PU23

lysine methylation increases dramatically in the anoxic state by 70% relative to the control condition

762099

alkylation

Trachemys scripta elegans

Q9I8C5, Q9PU23

lysine methylation of muscle PK increases significantly by 43% in the anoxic state compared to control

762099

phosphoprotein

Homo sapiens

-

-

738581

phosphoprotein

Homo sapiens

-

M2 pyruvate kinase is a substrate of delta protein kinase C. delta Protein kinase C activation in vitro or in cells does not appear to alter the enzyme activity or polymerization of M2 pyruvate kinase

692634

phosphoprotein

Homo sapiens

-

IgE receptor FcepsilonRI rapid phosphorylation of tyrosine residues in M2-PK leads to its inhibition and initiation of mast cell degranulation

721787

phosphoprotein

Homo sapiens

-

isozyme PKM2can be phosphorylated at Y105 by tyrosine kinases in cancer cells. The PKM2 conformational change caused by phosphorylation leads to FBP release and conversion of the enzyme from the tetramer to the less active dimer form

723661

phosphoprotein

Homo sapiens

P14618

phosphorylation at Ser residues by A-Raf, a Raf kinase isozyme or by PKC delta protein kinase C isozyme, phosphorylation at Y105 by fibroblast growth factor receptor-1, break point cluster region-ABL fusion Tyr kinase, ETV6-neurotrophic Tyr kinase receptor-3, and JAK-2 mutant V617F. Fibroblast growth factor receptor-dependent phosphorylation of iozyme PKM2 at Y105 causes its dimerization by the release of fructose 1,6-bisphosphate leading to Warburg effect

723720

phosphoprotein

Homo sapiens

-

phosphorylation of serine and threonine residues is, besides being essential for isozyme M2 catalytic activity, induces a trimeric association of the ProTalpha kinase. This association can be shifted to a tetrameric form by fructose 1,6-bisphosphate, which results in a decrease in ProTalphaK activity

721719

phosphoprotein

Homo sapiens

P30613

the phosphorylated N-terminus does not interact with the main body of the protein or does so with a very low binding energy

721690

phosphoprotein

Rattus norvegicus

-

-

708372

phosphoprotein

Trachemys scripta elegans

Q9I8C5, Q9PU23

anoxic red muscle PK shows a 42% increase in threonine phosphorylation relative to the control. But there are no significant differences in neither tyrosine nor serine residue phosphorylation between the control and anoxic states

762099

phosphoprotein

Trachemys scripta elegans

Q9I8C5, Q9PU23

liver PK shows 60% increased threonine phosphorylation levels in the anoxic state compared to control. Conversely, phosphorylation on tyrosine residues decreases by 26% for anoxic PK relative to control, whereas serine phosphorylation is unchanged

762099

phosphoprotein

Urocitellus richardsonii

-

torpid pyruvate kinase (PK) is significantly more phosphorylated than the euthermic control

761891

additional information

Cynodon dactylon

-

no S-S bonds

641625

additional information

Geobacillus stearothermophilus

-

no glycoprotein

641584