BRENDA - Enzyme Database show
show all sequences of 2.7.1.40

Pyruvate kinase M2: A key enzyme of the tumor metabolome and its medical relevance

Mazurek, S.; Biomed. Res. 23, 133-142 (2012)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
D-fructose 1,6-bisphosphate
induces an association of two inactive dimers to the active tetrameric form
Homo sapiens
D-fructose 1,6-bisphosphate
induces an association of two inactive dimers to the active tetrameric form. M2-PK showing ProTalpha kinase activity is a trimeric association and possesses no observable pyruvate kinase activity. This association can be shifted by fructose 1,6-P2 to the tetrameric form which results in a reduction of ProTalpha-kinase activity
Mus musculus
Application
Application
Commentary
Organism
diagnostics
M2-PK in stool is a screening marker for colorectal cancer. M2-PK in plasma is a marker for follow-up studies during tumor therapy
Homo sapiens
drug development
M2-PK is a potential target for tumor therapy, detailed overview
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
IgE receptor FcepsilonRI rapid phosphorylation of tyrosine residues in M2-PK leads to its inhibition and initiation of mast cell degranulation
Homo sapiens
suppressor of cytokine signaling 3
in dendritic cells the interaction of M2-PK with suppressor of cytokine signaling 3, SOCS3, induces a decrease of M2-PK activity and ATP production as well as an impairment of dendritic cell-based immunotherapy against tumors
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
additional information
nuclear translocation of M2-PK by the somatostatin analogue TT232, H2O2 or UV light
Homo sapiens
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Mus musculus
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + prothymosin alpha
Mus musculus
in normal murine lymphocytes and in tumor cells M2-PK phosphorylates prothymosin alpha on a threonine
ADP + phospho-prothymosin alpha
-
-
?
ATP + pyruvate
Mus musculus
-
ADP + phosphoenolpyruvate
-
-
r
ATP + pyruvate
Homo sapiens
-
ADP + phosphoenolpyruvate
-
-
r
additional information
Homo sapiens
nuclear M2-PK participates in the phosphorylation of the epsilon-amino group of histone 1 by direct phosphate transfer from PEP without requiring ATP. M2-PK directly inters with different oncoproteins and components of the protein kinase cascade, such as HPV-16 E7, the tyrosine kinases pp60v-src, BCR-ABL, ETV6-NTRK3, FGFR-1, FLT3 and JAK-2, the serine/threonine kinase A-Raf, cytoplasmic promyelocytic leukemia tumor suppressor protein as well as phosphotyrosine peptides
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
IgE receptor FcepsilonRI rapid phosphorylation of tyrosine residues in M2-PK leads to its inhibition and initiation of mast cell degranulation
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipocyte
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
embryo
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
Henles loop
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
lung
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
lymphocyte
-
Mus musculus
-
additional information
M2-type pyruvate kinase isoenzyme is expressed in different differentiated cells and tissues as well as in all proliferating cells. Increase of tumor M2-PK in plasma of patients with renal cell carcinoma, melanoma, lung, breast, cervical, ovarian, oesopharyngeal, gastric, pancreatic and colorectal cancer as well as in pleural fluid of patients with chest malignancies which correlates with tumor stages
Homo sapiens
-
additional information
M2-type pyruvate kinase isoenzyme is expressed in different differentiated cells and tissues as well as in all proliferating cells
Mus musculus
-
pancreatic islet
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
renal medulla
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
renal tubule
distal, expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
retina
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + prothymosin alpha
in normal murine lymphocytes and in tumor cells M2-PK phosphorylates prothymosin alpha on a threonine
721787
Mus musculus
ADP + phospho-prothymosin alpha
-
-
-
?
ATP + prothymosin alpha
ProTalpha kinase activity
721787
Mus musculus
ADP + phospho-prothymosin alpha
-
-
-
?
ATP + pyruvate
-
721787
Mus musculus
ADP + phosphoenolpyruvate
-
-
-
r
ATP + pyruvate
-
721787
Homo sapiens
ADP + phosphoenolpyruvate
-
-
-
r
additional information
nuclear M2-PK participates in the phosphorylation of the epsilon-amino group of histone 1 by direct phosphate transfer from PEP without requiring ATP. M2-PK directly inters with different oncoproteins and components of the protein kinase cascade, such as HPV-16 E7, the tyrosine kinases pp60v-src, BCR-ABL, ETV6-NTRK3, FGFR-1, FLT3 and JAK-2, the serine/threonine kinase A-Raf, cytoplasmic promyelocytic leukemia tumor suppressor protein as well as phosphotyrosine peptides
721787
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
nearly inactive dimeric form
Homo sapiens
dimer
nearly inactive dimeric form
Mus musculus
More
in tumors, the dimeric form of M2-PK is predominant due to direct interaction with different oncoproteins and components of the protein kinase cascade, such as HPV-16 E7, the tyrosine kinases pp60v-src, BCR-ABL, ETV6-NTRK3, FGFR-1, FLT3 and JAK-2, the serine/threonine kinase A-Raf, cytoplasmic promyelocytic leukemia tumor suppressor protein as well as phosphotyrosine peptides
Homo sapiens
tetramer
highly active tetrameric form
Homo sapiens
tetramer
highly active tetrameric form
Mus musculus
trimer
M2-PK showing ProTalpha kinase activity is a trimeric association and possesses no observable pyruvate kinase activity
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
ADP
-
Homo sapiens
ADP
-
Mus musculus
ATP
-
Mus musculus
ATP
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
D-fructose 1,6-bisphosphate
induces an association of two inactive dimers to the active tetrameric form
Homo sapiens
D-fructose 1,6-bisphosphate
induces an association of two inactive dimers to the active tetrameric form. M2-PK showing ProTalpha kinase activity is a trimeric association and possesses no observable pyruvate kinase activity. This association can be shifted by fructose 1,6-P2 to the tetrameric form which results in a reduction of ProTalpha-kinase activity
Mus musculus
Application (protein specific)
Application
Commentary
Organism
diagnostics
M2-PK in stool is a screening marker for colorectal cancer. M2-PK in plasma is a marker for follow-up studies during tumor therapy
Homo sapiens
drug development
M2-PK is a potential target for tumor therapy, detailed overview
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ADP
-
Homo sapiens
ADP
-
Mus musculus
ATP
-
Mus musculus
ATP
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
IgE receptor FcepsilonRI rapid phosphorylation of tyrosine residues in M2-PK leads to its inhibition and initiation of mast cell degranulation
Homo sapiens
suppressor of cytokine signaling 3
in dendritic cells the interaction of M2-PK with suppressor of cytokine signaling 3, SOCS3, induces a decrease of M2-PK activity and ATP production as well as an impairment of dendritic cell-based immunotherapy against tumors
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
additional information
nuclear translocation of M2-PK by the somatostatin analogue TT232, H2O2 or UV light
Homo sapiens
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Mus musculus
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + prothymosin alpha
Mus musculus
in normal murine lymphocytes and in tumor cells M2-PK phosphorylates prothymosin alpha on a threonine
ADP + phospho-prothymosin alpha
-
-
?
ATP + pyruvate
Mus musculus
-
ADP + phosphoenolpyruvate
-
-
r
ATP + pyruvate
Homo sapiens
-
ADP + phosphoenolpyruvate
-
-
r
additional information
Homo sapiens
nuclear M2-PK participates in the phosphorylation of the epsilon-amino group of histone 1 by direct phosphate transfer from PEP without requiring ATP. M2-PK directly inters with different oncoproteins and components of the protein kinase cascade, such as HPV-16 E7, the tyrosine kinases pp60v-src, BCR-ABL, ETV6-NTRK3, FGFR-1, FLT3 and JAK-2, the serine/threonine kinase A-Raf, cytoplasmic promyelocytic leukemia tumor suppressor protein as well as phosphotyrosine peptides
?
-
-
-
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
IgE receptor FcepsilonRI rapid phosphorylation of tyrosine residues in M2-PK leads to its inhibition and initiation of mast cell degranulation
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipocyte
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
embryo
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
Henles loop
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
lung
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
lymphocyte
-
Mus musculus
-
additional information
M2-type pyruvate kinase isoenzyme is expressed in different differentiated cells and tissues as well as in all proliferating cells. Increase of tumor M2-PK in plasma of patients with renal cell carcinoma, melanoma, lung, breast, cervical, ovarian, oesopharyngeal, gastric, pancreatic and colorectal cancer as well as in pleural fluid of patients with chest malignancies which correlates with tumor stages
Homo sapiens
-
additional information
M2-type pyruvate kinase isoenzyme is expressed in different differentiated cells and tissues as well as in all proliferating cells
Mus musculus
-
pancreatic islet
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
renal medulla
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
renal tubule
distal, expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
retina
expression of M2-type pyruvate kinase isoenzyme
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + prothymosin alpha
in normal murine lymphocytes and in tumor cells M2-PK phosphorylates prothymosin alpha on a threonine
721787
Mus musculus
ADP + phospho-prothymosin alpha
-
-
-
?
ATP + prothymosin alpha
ProTalpha kinase activity
721787
Mus musculus
ADP + phospho-prothymosin alpha
-
-
-
?
ATP + pyruvate
-
721787
Mus musculus
ADP + phosphoenolpyruvate
-
-
-
r
ATP + pyruvate
-
721787
Homo sapiens
ADP + phosphoenolpyruvate
-
-
-
r
additional information
nuclear M2-PK participates in the phosphorylation of the epsilon-amino group of histone 1 by direct phosphate transfer from PEP without requiring ATP. M2-PK directly inters with different oncoproteins and components of the protein kinase cascade, such as HPV-16 E7, the tyrosine kinases pp60v-src, BCR-ABL, ETV6-NTRK3, FGFR-1, FLT3 and JAK-2, the serine/threonine kinase A-Raf, cytoplasmic promyelocytic leukemia tumor suppressor protein as well as phosphotyrosine peptides
721787
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
nearly inactive dimeric form
Homo sapiens
dimer
nearly inactive dimeric form
Mus musculus
More
in tumors, the dimeric form of M2-PK is predominant due to direct interaction with different oncoproteins and components of the protein kinase cascade, such as HPV-16 E7, the tyrosine kinases pp60v-src, BCR-ABL, ETV6-NTRK3, FGFR-1, FLT3 and JAK-2, the serine/threonine kinase A-Raf, cytoplasmic promyelocytic leukemia tumor suppressor protein as well as phosphotyrosine peptides
Homo sapiens
tetramer
highly active tetrameric form
Homo sapiens
tetramer
highly active tetrameric form
Mus musculus
trimer
M2-PK showing ProTalpha kinase activity is a trimeric association and possesses no observable pyruvate kinase activity
Mus musculus
Expression
Organism
Commentary
Expression
Homo sapiens
HIF-1alpha induces an increased transcription of the pyruvate kinase M gene.. Induction of M2-PK expression by hypermethylated secreted frizzled related protein and mutated adenomatous polyposis coli protein, APC, overview
up
General Information
General Information
Commentary
Organism
malfunction
missense mutations of M2-PK are described in the lymphocytes of an Indian Bloom syndrome patient. Inhibition of M2-PK isdirectly linked with the initiation of mast cell degranulation
Homo sapiens
additional information
expression of M2-PK is under the control of nutrients, insulin, different transcription factors such as SP1, SP3, HIF-1alpha, as well as c-myc, the zonula occludens protein 2 (ZO-2), Ras and microRNA 133a and 133b
Homo sapiens
physiological function
pyruvate kinase is a glycolytic enzyme catalyzing the ATP regenerating dephosphorylation of phosphoenolpyruvate to pyruvate. Pyruvate kinase is responsible for net ATP production within the glycolytic sequence. Besides its role as glycolytic enzyme M2-PK may also function as protein kinase. In tumor metabolism the quaternary structure of M2-PK (tetramer:dimer ratio) determines whether glucose is used for glycolytic energy regeneration (highly active tetrameric form, Warburg effect) or synthesis of cell building blocks (nearly inactive dimeric form) which are both prerequisites for cells with a high proliferation rate. In tumor cells the nearly inactive dimeric form of M2-PK is predominant due to direct interactions with different oncoproteins. Besides its key functions in tumor metabolism, M2-PK may also react as protein kinase as well as co activator of transcription factors. The mTOR/HIF-1a/c-myc/M2-PK cascade may be one explanation for the increased aerobic glycolysis in tumor cells first described by Otto Warburg, overview. Nuclear translocation of M2-PK by the somatostatin analogue TT232, H2O2 or UV light are linked to the induction of caspase independent apoptosis. M2-PK binds to the mast cell IgE receptor FcepsilonRI and plays a crucial role in responses to allergens
Homo sapiens
physiological function
pyruvate kinase is a glycolytic enzyme catalyzing the ATP regenerating dephosphorylation of phosphoenolpyruvate to pyruvate. Pyruvate kinase is responsible for net ATP production within the glycolytic sequence. Besides its role as glycolytic enzyme M2-PK may also function as protein kinase
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
missense mutations of M2-PK are described in the lymphocytes of an Indian Bloom syndrome patient. Inhibition of M2-PK isdirectly linked with the initiation of mast cell degranulation
Homo sapiens
additional information
expression of M2-PK is under the control of nutrients, insulin, different transcription factors such as SP1, SP3, HIF-1alpha, as well as c-myc, the zonula occludens protein 2 (ZO-2), Ras and microRNA 133a and 133b
Homo sapiens
physiological function
pyruvate kinase is a glycolytic enzyme catalyzing the ATP regenerating dephosphorylation of phosphoenolpyruvate to pyruvate. Pyruvate kinase is responsible for net ATP production within the glycolytic sequence. Besides its role as glycolytic enzyme M2-PK may also function as protein kinase. In tumor metabolism the quaternary structure of M2-PK (tetramer:dimer ratio) determines whether glucose is used for glycolytic energy regeneration (highly active tetrameric form, Warburg effect) or synthesis of cell building blocks (nearly inactive dimeric form) which are both prerequisites for cells with a high proliferation rate. In tumor cells the nearly inactive dimeric form of M2-PK is predominant due to direct interactions with different oncoproteins. Besides its key functions in tumor metabolism, M2-PK may also react as protein kinase as well as co activator of transcription factors. The mTOR/HIF-1a/c-myc/M2-PK cascade may be one explanation for the increased aerobic glycolysis in tumor cells first described by Otto Warburg, overview. Nuclear translocation of M2-PK by the somatostatin analogue TT232, H2O2 or UV light are linked to the induction of caspase independent apoptosis. M2-PK binds to the mast cell IgE receptor FcepsilonRI and plays a crucial role in responses to allergens
Homo sapiens
physiological function
pyruvate kinase is a glycolytic enzyme catalyzing the ATP regenerating dephosphorylation of phosphoenolpyruvate to pyruvate. Pyruvate kinase is responsible for net ATP production within the glycolytic sequence. Besides its role as glycolytic enzyme M2-PK may also function as protein kinase
Mus musculus
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
HIF-1alpha induces an increased transcription of the pyruvate kinase M gene.. Induction of M2-PK expression by hypermethylated secreted frizzled related protein and mutated adenomatous polyposis coli protein, APC, overview
up
Other publictions for EC 2.7.1.40
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748573
Patil
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1
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1
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1
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Adem
Inhibitory and Activating Effe ...
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Arch. Pharm.
349
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7
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5
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2
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1
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1
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5
7
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5
5
-
-
-
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1
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-
-
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1
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1
-
-
-
-
-
-
-
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1
1
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739675
He
Pyruvate kinase M2 activates m ...
Homo sapiens
Sci. Rep.
6
21524
2016
-
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-
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1
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2
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1
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2
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2
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1
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2
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2
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2
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1
1
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739682
Kim
Redirection of pyruvate flux t ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae CEN.PK2-1C
Sci. Rep.
6
24145
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1
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2
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3
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
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-
730677
De la Vega-Ruíz
New insights on the mechanism ...
Thermofilum pendens
PLoS One
10
e0119233
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-
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1
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-
-
2
3
-
3
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-
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8
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1
1
-
-
-
-
1
-
1
-
2
5
1
-
-
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1
-
-
-
-
1
-
-
-
-
-
2
1
3
-
3
-
-
-
-
-
1
-
-
-
-
1
-
1
-
2
5
1
-
-
-
-
-
-
-
1
1
738760
Strumilo
-
Dissimilar properties of pyruv ...
Lepus europaeus, Oryctolagus cuniculus
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51
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-
-
-
-
-
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2
-
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-
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2
-
2
-
-
2
-
-
4
-
-
2
-
2
-
2
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
4
2
-
-
-
-
-
2
-
-
-
2
-
4
-
-
2
-
2
-
2
-
2
-
-
-
-
-
-
-
-
-
739576
Auslender
Expression, purification and c ...
Solanum tuberosum
Protein Expr. Purif.
110
7-13
2015
-
-
1
-
-
-
2
-
3
-
1
1
-
4
-
-
1
-
-
3
2
-
1
1
1
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
3
-
1
1
-
-
-
1
-
3
2
-
1
1
1
-
1
-
-
1
-
-
-
-
-
-
-
-
739755
Chen
Mechanisms of pyruvate kinase ...
Homo sapiens
World J. Gastroenterol.
21
9093-9102
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
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1
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3
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1
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-
-
-
-
-
-
-
-
2
2
-
-
-
737416
van Oirschot
Novel type of red blood cell p ...
Homo sapiens
Am. J. Hematol.
89
380-384
2014
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-
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1
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1
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1
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1
-
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-
-
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2
2
-
-
-
721683
Urness
Distinguishing the chemical mo ...
Oryctolagus cuniculus
Biochemistry
52
1-3
2013
-
-
-
-
-
-
2
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1
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1
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2
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2
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1
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1
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1
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1
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1
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2
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1
-
-
-
-
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-
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-
-
-
1
1
-
-
-
721688
Prasannan
Identification of regions of r ...
Oryctolagus cuniculus
Biochemistry
52
1998-2006
2013
-
-
-
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-
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2
-
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2
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1
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2
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3
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1
1
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1
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1
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2
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2
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1
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3
-
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1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721690
Holyoak
Energetic coupling between an ...
Homo sapiens
Biochemistry
52
466-476
2013
-
-
-
1
14
-
1
10
-
1
-
1
-
2
-
1
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-
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2
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1
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1
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1
1
14
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1
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10
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1
-
1
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1
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-
2
-
-
1
-
-
-
-
-
-
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-
-
-
2
2
-
-
-
723094
Deng
Redirecting carbon flux throug ...
no activity in Clostridium thermocellum, Thermoanaerobacterium saccharolyticum
Metab. Eng.
15
151-158
2013
-
-
1
-
1
-
-
-
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1
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1
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5
-
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4
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1
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1
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1
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2
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1
2
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1
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1
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1
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4
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
723703
Hofmann
Recombinant production of Yers ...
Yersinia enterocolitica, Yersinia enterocolitica WA-314
Protein Expr. Purif.
88
243-247
2013
1
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1
1
-
-
-
-
-
1
2
2
-
6
-
-
1
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2
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2
1
1
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1
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1
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1
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1
1
1
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1
2
2
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1
-
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2
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
727026
Solomons
3-Phosphoglycerate is an allos ...
Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523
Biochemistry
52
5865-5875
2013
1
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1
1
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-
-
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2
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7
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1
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4
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1
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2
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1
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4
-
-
-
-
-
-
-
-
-
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1
1
-
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737796
Boehme
Chemical and enzymatic charact ...
Oryctolagus cuniculus
Biol. Chem.
394
695-701
2013
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1
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4
4
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2
2
2
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3
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1
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2
-
3
3
1
1
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1
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1
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4
-
4
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2
2
2
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1
-
2
-
3
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
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738581
Gao
Reciprocal regulation of prote ...
Homo sapiens
J. Biol. Chem.
288
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2013
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1
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1
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1
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1
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1
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1
1
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1
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1
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1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
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739395
Veith
Organism-adapted specificity o ...
Enterococcus faecalis, Lactobacillus plantarum, Lactococcus lactis, Streptococcus mutans, Streptococcus pyogenes
PLoS Comput. Biol.
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2013
5
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11
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5
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5
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5
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5
-
-
-
-
-
-
-
-
-
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721131
Axerio-Cilies
Cheminformatics-driven discove ...
Staphylococcus aureus
ACS Chem. Biol.
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350-359
2012
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1
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20
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1
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1
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3
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1
1
1
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1
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10
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1
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1
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-
10
20
-
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1
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1
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-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
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1
1
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721544
Morgan
A new family of covalent inhib ...
Leishmania mexicana
Biochem. J.
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2012
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1
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1
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1
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1
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1
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2
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1
1
1
1
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2
4
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1
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1
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-
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1
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-
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1
-
1
-
-
-
1
-
-
-
-
1
1
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-
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721787
Mazurek
-
Pyruvate kinase M2: A key enzy ...
Homo sapiens, Mus musculus
Biomed. Res.
23
133-142
2012
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2
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-
-
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2
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2
2
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4
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2
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1
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11
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5
6
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-
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4
-
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2
2
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4
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-
-
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2
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2
2
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4
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1
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-
11
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-
5
6
-
-
-
-
-
-
-
-
1
4
4
1
-
-
721818
Yacovan
1-(sulfonyl)-5-(arylsulfonyl)i ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
6460-6468
2012
32
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-
-
-
-
-
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1
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1
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1
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
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1
1
-
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721843
Kumar
Optimization and structure-act ...
Staphylococcus aureus
Bioorg. Med. Chem.
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7069-7082
2012
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1
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1
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53
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-
-
-
-
-
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-
-
-
-
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-
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721966
Chen
Vitamin K3 and K5 are inhibito ...
Homo sapiens
Cancer Lett.
316
204-210
2012
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1
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-
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5
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1
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1
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1
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1
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3
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1
-
1
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1
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1
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10
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1
1
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-
10
5
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1
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1
-
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1
-
3
-
-
1
-
1
-
-
-
1
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-
-
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2
2
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-
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722155
Li
Probing the catalytic alloster ...
Oryctolagus cuniculus
Eur. Biophys. J.
41
607-614
2012
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1
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2
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2
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3
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2
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1
1
1
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1
-
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2
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-
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1
2
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2
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2
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3
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1
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1
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2
-
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1
1
1
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-
-
1
-
-
-
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2
2
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723111
Meza
Consequences of phosphoenolpyr ...
Escherichia coli, Escherichia coli K-12 W3110
Microb. Cell Fact.
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127
2012
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1
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1
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2
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4
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2
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1
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1
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1
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1
-
1
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-
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1
-
2
-
-
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-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
723269
Chaneton
Serine is a natural ligand and ...
Homo sapiens
Nature
491
458-462
2012
2
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-
-
3
-
1
-
1
1
-
1
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2
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-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
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2
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-
1
-
3
-
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1
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-
1
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
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-
-
723275
Benjaphokee
CDC19 encoding pyruvate kinase ...
Saccharomyces cerevisiae
New Biotechnol.
29
166-176
2012
-
-
1
-
1
-
-
-
-
-
-
-
-
2
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-
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-
-
-
-
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-
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-
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-
-
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-
-
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-
1
-
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1
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
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723590
Cook
Crystal structure of Cryptospo ...
Cryptosporidium parvum
PLoS ONE
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e46875
2012
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-
1
1
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-
-
-
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2
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1
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2
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1
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-
-
-
-
1
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
2
2
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-
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723661
Ye
Pyruvate kinase M2 promotes de ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
109
6904-6909
2012
2
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-
-
-
-
-
-
-
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1
-
1
-
-
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1
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1
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-
-
-
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-
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2
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-
-
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-
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-
-
-
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1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
721634
Alontaga
Effector analogues detect vari ...
Homo sapiens
Biochemistry
50
1934-1939
2011
-
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1
-
1
-
8
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1
-
1
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3
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1
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5
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1
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1
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1
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1
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-
1
1
-
1
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-
8
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-
1
-
1
-
-
-
1
-
5
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
721719
Diaz-Jullien
The M2-type isoenzyme of pyruv ...
Homo sapiens
Biochim. Biophys. Acta
1814
355-365
2011
-
-
-
-
-
-
1
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1
1
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2
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2
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1
1
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2
-
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3
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-
-
-
1
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-
1
-
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-
-
-
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1
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-
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1
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-
1
1
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2
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1
1
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
1
1
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721806
Walsh
2-Oxo-N-aryl-1,2,3,4-tetrahydr ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
6322-6327
2011
75
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1
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1
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75
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1
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-
-
-
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1
1
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-
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721988
Gruening
Pyruvate kinase triggers a met ...
Saccharomyces cerevisiae
Cell Metab.
14
415-427
2011
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-
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1
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1
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1
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1
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1
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1
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1
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1
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-
-
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1
1
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723044
Mandal
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Kinetic and expression profili ...
Brassica juncea, Brassica juncea Pusa Bold
J. Plant Biochem. Biotechnol.
20
102-109
2011
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1
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4
1
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2
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1
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1
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2
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1
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2
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1
1
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2
6
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3
2
1
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2
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1
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4
1
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2
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1
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1
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2
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1
1
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734842
Haferkamp
-
Biochemical studies of enzymes ...
Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1617
PH. D. Thesis Universität Duisburg-Essen
2011
0000
2011
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1
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1
8
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2
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2
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1
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8
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1
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1
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1
1
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8
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2
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4
1
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8
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8
707247
Pan
Enhanced recombinant protein p ...
Bacillus subtilis 168, Bacillus subtilis
Appl. Microbiol. Biotechnol.
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1769-1778
2010
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1
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1
1
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1
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1
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2
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707282
Pizzuto
Pyruvate kinase in pig liver m ...
Sus scrofa
Arch. Biochem. Biophys.
495
42-48
2010
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3
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1
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2
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1
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1
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2
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1
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707450
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Identification of small molecu ...
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3
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707589
Zhu
The quaternary structure of py ...
Escherichia coli
Biochimie
92
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2010
2
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2
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2
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1
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1
1
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707994
Zhang
Antigen presentation by dendri ...
Mus musculus
Cancer Res.
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2010
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1
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1
1
1
1
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710051
David
HnRNP proteins controlled by c ...
Mus musculus
Nature
463
364-368
2010
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5
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1
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1
1
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721624
Zoraghi
Functional analysis, overexpre ...
Escherichia coli, Staphylococcus aureus, Staphylococcus aureus MRSA252
Biochemistry
49
7733-7747
2010
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2
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2
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2
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2
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3
3
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1
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3
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3
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4
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3
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4
4
3
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3
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4
4
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722396
Ou
The conformational change of r ...
Oryctolagus cuniculus
Int. J. Biol. Macromol.
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2010
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1
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2
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1
1
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722668
Morgan
Allosteric mechanism of pyruva ...
Leishmania mexicana
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285
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1
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1
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1
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1
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2
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1
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1
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1
1
1
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1
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2
2
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723520
Bakszt
The crystal structure of Toxop ...
Toxoplasma gondii
PLoS ONE
5
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2010
4
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1
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3
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1
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8
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1
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1
1
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1
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4
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1
1
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3
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1
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1
1
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2
2
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723720
Gupta
Human pyruvate kinase M2: a mu ...
Homo sapiens
Protein Sci.
19
2031-2044
2010
1
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2
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6
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1
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2
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2
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1
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2
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2
2
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-
-
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2
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1
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1
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1
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2
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6
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1
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2
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1
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2
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2
2
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-
-
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2
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-
-
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3
3
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704094
Dimou
Co-localization of carbonic an ...
Glycine max
Int. J. Mol. Sci.
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2009
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1
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4
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4
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1
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1
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1
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1
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4
-
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1
-
-
-
-
-
-
-
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704746
Sawada
Key role for transketolase act ...
Moniliella megachiliensis, Moniliella megachiliensis SN-G42
J. Biosci. Bioeng.
108
385-390
2009
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1
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1
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1
1
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706831
Lepper
Lead inhibits in vitro creatin ...
Rattus norvegicus
Toxicol. In Vitro
24
1045-1051
2009
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2
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1
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2
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1
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1
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1
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2
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1
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2
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1
-
-
-
-
-
-
-
-
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-
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-
-
-
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707274
Fenton
The pH dependence of the allos ...
Homo sapiens
Arch. Biochem. Biophys.
484
16-23
2009
1
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1
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3
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2
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1
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2
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1
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1
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1
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1
1
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3
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1
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2
-
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1
-
-
-
-
-
-
-
-
-
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-
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-
-
707337
Barrs
Erythrocytic pyruvate kinase d ...
Felis catus
Aust. Vet. J.
87
39-44
2009
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-
-
-
-
-
-
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2
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-
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3
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1
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1
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1
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3
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707493
Fenton
An activating interaction betw ...
Homo sapiens
Biochemistry
48
3816-3818
2009
1
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-
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2
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2
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2
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2
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1
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1
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1
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1
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2
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2
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2
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707515
Herman
Functional energetic landscape ...
Oryctolagus cuniculus
Biochemistry
48
9448-9455
2009
-
-
-
-
-
-
1
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-
-
-
-
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2
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-
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2
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1
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1
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-
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1
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1
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2
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707516
Herman
Functional energetic landscape ...
Oryctolagus cuniculus
Biochemistry
48
9456-9465
2009
-
-
-
-
-
-
1
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-
-
-
-
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2
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-
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-
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2
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1
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1
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-
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1
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-
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1
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-
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2
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
707517
Herman
Functional energetic landscape ...
Oryctolagus cuniculus
Biochemistry
48
9466-9470
2009
-
-
-
-
-
-
1
-
-
-
-
-
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2
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-
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1
-
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1
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-
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-
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-
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1
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-
-
-
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1
-
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-
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1
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-
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-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707643
Murakami
Iron-dependent oxidative inact ...
Oryctolagus cuniculus
Biol. Trace Elem. Res.
130
31-38
2009
-
-
-
-
-
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2
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1
1
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2
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-
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2
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1
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-
-
-
-
-
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1
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-
-
-
-
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1
-
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-
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2
-
-
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1
1
-
-
-
-
-
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707871
Aloysius
Complete absence of M2-pyruvat ...
Homo sapiens
BMC Cancer
9
327
2009
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-
-
-
-
-
-
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1
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4
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5
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1
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-
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-
-
-
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1
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-
-
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-
-
1
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-
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-
-
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-
-
-
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1
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-
-
-
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5
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1
-
-
-
-
-
-
-
-
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1
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1
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707908
Finkenstedt
Regulation of iron metabolism ...
Homo sapiens
Br. J. Haematol.
144
789-793
2009
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-
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1
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1
-
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1
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-
-
-
-
-
-
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1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708196
Kedar
Spectrum of novel mutations in ...
Homo sapiens
Clin. Genet.
75
157-162
2009
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-
-
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12
-
-
-
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1
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2
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1
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1
-
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-
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-
-
-
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1
-
-
-
-
-
-
1
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12
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
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1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
708378
Johnson
Faecal M2-pyruvate kinase: a n ...
Homo sapiens
Eur. J. Gastroenterol. Hepatol.
21
544-550
2009
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1
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1
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2
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1
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1
1
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-
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-
-
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1
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-
-
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1
-
1
-
-
-
-
-
-
-
-
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1
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-
-
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1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
708413
Spoden
Pyruvate kinase isoenzyme M2 i ...
Mus musculus
Exp. Cell Res.
315
2765-2774
2009
-
-
-
-
-
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1
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-
-
-
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1
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1
-
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1
1
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-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
708661
van Wijk
Fifteen novel mutations in PKL ...
Homo sapiens
Hum. Mutat.
30
446-453
2009
-
-
-
-
13
-
-
-
-
-
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1
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2
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1
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1
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-
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-
-
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-
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1
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-
-
-
-
-
1
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13
-
-
-
-
-
-
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1
-
-
-
-
-
1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708922
Cunningham
Pyruvate kinase-deficient Esch ...
Escherichia coli, Escherichia coli JM101
J. Bacteriol.
191
3041-3049
2009
-
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2
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10
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-
-
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2
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-
-
-
-
-
-
1
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-
-
-
-
-
1
-
-
-
-
-
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-
-
-
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2
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-
-
-
-
-
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2
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-
-
-
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-
-
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1
1
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708931
Chavadi
Global effects of inactivation ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Bacteriol.
191
7545-7553
2009
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2
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-
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1
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-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
709010
Akhtar
Differential behavior of misse ...
Homo sapiens
J. Biol. Chem.
284
11971-11981
2009
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1
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2
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1
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2
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1
-
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1
-
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1
1
-
-
3
-
1
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1
6
-
-
1
-
1
1
-
2
-
-
1
6
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-
-
-
-
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-
-
1
-
1
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1
1
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3
-
1
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709228
Spoden
The SUMO-E3 ligase PIAS3 targe ...
Homo sapiens
J. Cell. Biochem.
107
293-302
2009
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1
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1
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1
-
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2
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
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2
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-
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1
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1
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2
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-
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709379
Ayi
Adenosine triphosphate depleti ...
Homo sapiens
J. Infect. Dis.
200
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2009
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3
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3
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1
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-
-
-
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1
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
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1
-
-
-
-
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3
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1
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-
-
-
-
-
-
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-
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1
1
-
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709464
Boxer
Evaluation of substituted N,N ...
Homo sapiens
J. Med. Chem.
53
1048-1055
2009
18
-
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2
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1
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1
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1
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18
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1
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2
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1
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709817
Delwing
Protective effect of antioxida ...
Rattus norvegicus
Metab. Brain Dis.
24
469-479
2009
-
-
-
-
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1
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3
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2
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1
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1
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2
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1
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709909
Martinez-Balibrea
A proteomic approach links dec ...
Homo sapiens
Mol. Cancer Ther.
8
771-778
2009
-
1
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1
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2
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3
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1
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1
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1
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1
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1
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3
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1
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2
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2
-
-
710022
Meza
Rescue of pyruvate kinase defi ...
Homo sapiens
Mol. Ther.
17
2000-2009
2009
-
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1
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3
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6
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1
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1
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1
1
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6
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1
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710084
Ishida
Synaptic vesicle-bound pyruvat ...
Rattus norvegicus
Neurochem. Res.
34
807-818
2009
-
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1
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1
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1
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1
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1
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1
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1
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1
1
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710195
Maeda
Pyruvate kinase type-II isozym ...
Plasmodium falciparum
Parasitol. Int.
58
101-105
2009
-
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1
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3
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1
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4
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1
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1
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1
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1
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1
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1
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1
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1
1
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-
-
690398
Asanuma
Molecular properties and trans ...
Streptococcus equinus
Anaerobe
14
237-241
2008
-
-
-
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1
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3
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2
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1
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2
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-
691080
Iori
Glycolytic enzyme expression a ...
Homo sapiens
Biochim. Biophys. Acta
1782
627-633
2008
-
1
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2
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2
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1
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2
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691167
Ogasawara
Pyruvate kinase is protected b ...
Homo sapiens
Biol. Pharm. Bull.
31
1875-1881
2008
-
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3
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2
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1
2
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1
2
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691527
Haug
Sensitivity and specificity of ...
Homo sapiens
Br. J. Cancer
99
133-135
2008
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1
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1
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691908
Echigoya
Molecular characterization and ...
Equus caballus
Comp. Biochem. Physiol. B
151
125-132
2008
-
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1
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6
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4
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1
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1
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7
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1
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692317
Dharmarajan
Tyr235 of human cytosolic phos ...
Homo sapiens
FEBS J.
275
5810-5819
2008
-
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1
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3
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3
1
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1
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1
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1
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1
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3
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3
1
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1
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1
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-
692347
Wu
Isoform-specific interaction o ...
Homo sapiens
FEBS Lett.
582
2155-2160
2008
-
1
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1
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2
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1
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1
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1
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1
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-
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-
-
-
692474
Sandoval
A biochemical and genetic stud ...
Leishmania donovani
Gene
424
25-32
2008
2
-
1
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3
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1
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1
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4
-
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4
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1
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1
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2
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1
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3
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1
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1
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4
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1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
692488
Shimada
Modulation of M2-type pyruvate ...
Homo sapiens
Genes Cells
13
245-254
2008
-
1
-
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1
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-
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1
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1
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1
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1
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1
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1
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1
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-
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-
-
692553
Derks
Inhibition of mitochondrial fa ...
Mus musculus
Hepatology
47
1032-1042
2008
-
1
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1
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2
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-
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-
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-
692662
Spoden
Isotype-specific inhibitors of ...
Homo sapiens
Int. J. Cancer
123
312-321
2008
-
-
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3
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2
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1
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1
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-
-
-
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-
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-
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-
-
-
-
692916
Suzuki
Crystal structure of pyruvate ...
Geobacillus stearothermophilus
J. Biochem.
144
305-312
2008
2
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1
1
5
-
-
-
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4
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1
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2
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1
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1
5
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1
-
-
-
-
-
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-
-
-
-
-
-
-
-
693666
Tulloch
Sulphate removal induces a maj ...
Leishmania mexicana
J. Mol. Biol.
383
615-626
2008
1
-
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1
5
-
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2
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-
-
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2
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1
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1
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1
5
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2
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693793
Ameho
Antioxidant activity and metab ...
Rattus norvegicus
J. Nutr. Biochem.
19
467-474
2008
-
2
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2
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693950
Detaille
Interrelation between the inhi ...
Rattus norvegicus
Life Sci.
82
1070-1076
2008
-
-
-
-
-
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1
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4
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695067
Doran
Opposite pathobiochemical fate ...
Rattus norvegicus
Proteomics
8
364-377
2008
-
1
-
-
-
-
-
-
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2
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2
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1
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-
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706939
Lee
Modulation of allostery of pyr ...
Oryctolagus cuniculus
Acta Biochim. Biophys. Sin.
40
663-669
2008
1
-
-
-
2
-
1
-
-
1
-
1
-
1
-
-
-
-
-
2
-
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1
1
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-
-
-
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1
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1
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1
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2
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1
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1
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1
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-
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2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707158
Mazurek
Regulation of pyruvate kinase ...
Mus musculus
Anticancer Res.
27
3963-3971
2008
2
-
-
-
-
-
1
-
-
-
-
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2
-
-
-
-
-
2
-
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1
1
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-
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1
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2
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1
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-
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1
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-
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-
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2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707838
Yavarian
Prevalence of pyruvate kinase ...
Homo sapiens
Blood Cells Mol. Dis.
40
308-311
2008
-
-
-
-
1
-
-
-
-
-
-
-
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2
-
-
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-
-
1
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1
-
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-
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1
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1
-
1
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-
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-
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-
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707914
Ryu
Regulation of M2-type pyruvate ...
Rattus norvegicus
Br. J. Pharmacol.
154
1035-1046
2008
1
-
-
-
-
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2
2
-
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3
-
-
-
-
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1
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1
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-
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-
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1
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1
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1
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2
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2
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
708214
Koss
Faecal dimeric M2 pyruvate kin ...
Homo sapiens
Colorectal Dis.
10
244-248
2008
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
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1
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1
-
1
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-
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1
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
708344
Gao
-
Substrate promiscuity of pyruv ...
Bacillus sp. (in: Bacteria), Oryctolagus cuniculus, Zymomonas mobilis
Enzyme Microb. Technol.
43
455-459
2008
-
-
2
-
-
-
-
-
-
-
2
-
-
3
-
-
2
-
-
1
-
-
15
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
3
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
1
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708372
O’Connell
Lectin-based proteomic profili ...
Rattus norvegicus
Eur. J. Cell Biol.
87
793-805
2008
-
-
-
-
-
-
-
-
-
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1
-
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3
-
1
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-
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1
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-
1
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-
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-
-
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1
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2
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
708439
Oka
Babesia rodhaini: the protecti ...
Mus musculus
Exp. Parasitol.
120
290-294
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
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-
1
-
-
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-
-
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1
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1
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-
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
708734
Kim
Granule formation in NGF-cultu ...
Homo sapiens
Int. Arch. Allergy Immunol.
146
287-297
2008
-
-
-
-
-
-
-
-
-
-
1
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4
-
-
-
-
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2
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Pyruvate kinase M2 is a phosph ...
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Relative red blood cell enzyme ...
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A heteromeric plastidic pyruva ...
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Use of a novel method to find ...
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Characterization of yeast pyru ...
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Differentiating a ligands chem ...
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Regulating expression of pyruv ...
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Labbe
Eimeria tenella enolase and py ...
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Pendergrass
Mining for allosteric informat ...
Homo sapiens
IUBMB Life
58
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2006
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-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
661215
Dombrauckas
Structural basis for tumor pyr ...
Homo sapiens
Biochemistry
44
9417-9429
2005
1
1
-
1
-
-
-
4
-
-
-
-
-
3
-
-
1
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-
1
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1
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1
1
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1
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4
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
662901
Stamm
The pyruvate kinase of Stigmat ...
Stigmatella aurantiaca
Mol. Microbiol.
56
1386-1395
2005
1
-
1
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-
-
-
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1
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4
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2
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1
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1
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2
-
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-
-
-
-
-
-
-
-
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-
-
-
-
663020
Papadopoulos
-
Effect of insecticide injectio ...
Tenebrio molitor
Pestic. Biochem. Physiol.
82
115-124
2005
2
-
-
-
-
-
-
4
1
-
-
-
-
1
-
-
1
-
-
4
1
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1
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-
-
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-
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2
-
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4
1
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1
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4
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671085
Suzuki
Crystallization and preliminar ...
Geobacillus stearothermophilus
Acta Crystallogr. Sect. F
61
759-761
2005
2
-
1
1
1
-
-
-
-
-
-
-
-
2
-
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1
-
-
-
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1
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2
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2
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1
2
1
1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674052
Feksa
The effects of the interaction ...
Rattus norvegicus
Int. J. Dev. Neurosci.
23
509-514
2005
-
-
-
-
-
-
4
2
-
-
-
-
-
2
-
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2
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1
-
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1
1
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1
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4
1
2
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2
-
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1
-
-
-
-
-
-
-
-
-
-
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-
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-
674350
Sakai
Mutagenesis of the active site ...
Geobacillus stearothermophilus
J. Biochem.
137
141-145
2005
1
-
1
-
6
-
-
2
-
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-
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2
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1
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1
-
1
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1
-
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2
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1
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1
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1
1
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6
-
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2
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-
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1
1
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
674499
Oria-Hernandez
Pyruvate kinase revisited: the ...
Homo sapiens
J. Biol. Chem.
280
37924-37929
2005
-
-
1
-
1
-
2
6
-
2
-
-
-
1
-
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1
-
-
-
2
-
1
1
-
-
-
3
-
-
-
1
6
-
-
-
-
1
1
-
1
-
-
2
6
6
-
2
-
-
-
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1
-
-
2
-
1
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
675943
Peltier
Effect of exogenous adenosine ...
Rattus norvegicus
Mol. Cell. Biochem.
277
55-61
2005
1
-
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-
-
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4
-
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2
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2
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1
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1
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1
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1
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4
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676298
Narli
The activity and kinetics of p ...
Homo sapiens
Pediatr. Hematol. Oncol.
22
567-573
2005
-
-
-
-
-
-
-
1
-
-
-
-
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1
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-
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1
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1
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676689
Turner
Cytosolic pyruvate kinase: sub ...
Glycine max, Ricinus communis
Planta
222
1051-1062
2005
1
-
-
-
-
2
9
8
5
2
4
-
-
7
-
-
1
-
-
8
2
-
2
2
-
-
-
-
1
1
-
2
-
-
5
1
-
-
2
-
-
2
5
9
-
8
5
2
4
-
-
-
-
1
-
8
2
-
2
2
-
-
-
-
1
1
-
-
-
-
-
-
-
-
661108
Susan-Resiga
Proton donor in yeast pyruvate ...
Saccharomyces cerevisiae
Biochemistry
43
15230-15245
2004
1
-
-
-
1
-
-
7
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
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1
-
-
-
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1
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-
-
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7
-
1
-
-
-
-
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1
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
661404
Feksa
Inhibition of pyruvate kinase ...
Rattus norvegicus
Brain Res.
1012
93-100
2004
-
-
-
-
-
-
1
2
-
-
-
-
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4
-
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3
-
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1
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1
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2
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661672
Saavedra
Entamoeba histolytica: kinetic ...
Entamoeba histolytica
Exp. Parasitol.
106
11-21
2004
-
-
1
-
-
-
2
2
-
-
-
-
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2
-
-
-
-
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2
-
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1
-
1
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
2
-
-
-
-
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-
-
2
-
-
1
-
1
1
1
-
1
-
-
-
-
-
-
-
-
-
641614
Maeda
Expression and characterizatio ...
Toxoplasma gondii
Parasitol. Res.
89
259-265
2003
2
-
1
-
-
-
2
-
-
-
2
-
-
3
-
-
-
-
-
1
-
1
1
1
-
-
1
-
1
-
-
-
1
-
-
2
-
1
-
-
-
-
-
2
1
-
-
-
2
-
-
-
-
-
-
1
-
1
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
641620
Susan-Resiga
The Proton Transfer Step Catal ...
Saccharomyces cerevisiae
J. Biol. Chem.
278
12660-12671
2003
-
-
-
-
3
-
-
-
-
2
-
-
-
2
-
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-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
-
-
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-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
660823
Yilmaz
Comparison of pyruvate kinase ...
Homo sapiens
Arch. Med. Res.
34
315-324
2003
-
-
-
-
-
-
1
-
-
-
1
-
-
3
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
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1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661406
Feksa
Characterization of the inhibi ...
Rattus norvegicus
Brain Res.
968
199-205
2003
-
-
-
-
-
-
2
-
-
-
-
1
-
4
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
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2
-
-
-
-
-
1
-
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-
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3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661513
Ohta
Molecular cloning and expressi ...
Takifugu rubripes
Comp. Biochem. Physiol. B
135
397-405
2003
1
-
1
-
-
-
3
3
-
-
2
-
-
2
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
3
-
-
2
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661514
Lemos
Citrate synthase and pyruvate ...
Penaeus paulensis
Comp. Biochem. Physiol. B
135
707-719
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661628
Ramirez-Silva
Selectivity of pyruvate kinase ...
Oryctolagus cuniculus
Eur. J. Biochem.
270
2377-2385
2003
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662143
Johnsen
Comparative analysis of pyruva ...
Aeropyrum pernix, Archaeoglobus fulgidus, Archaeoglobus fulgidus 7324, Pyrobaculum aerophilum, Thermotoga maritima
J. Biol. Chem.
278
25417-25427
2003
1
-
3
-
-
-
3
-
-
20
10
-
-
10
-
-
4
-
-
-
2
-
-
4
4
-
7
-
5
3
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
-
20
10
-
-
-
-
4
-
-
2
-
-
4
4
-
7
-
5
3
-
-
-
-
-
-
-
-
641604
Ambasht
-
Plant pyruvate kinase ...
Brassica napus, Brassica rapa subsp. oleifera, Cynodon dactylon, Monoraphidium minutum, Ricinus communis, Spinacia oleracea
Biol. Plant.
45
1-10
2002
-
-
-
-
-
-
-
6
-
11
-
6
-
6
-
-
6
6
-
-
-
-
12
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
11
-
6
-
-
-
6
-
-
-
-
12
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641613
Iliffe-Lee
Pyruvate kinase from Chlamydia ...
Chlamydia trachomatis
Mol. Microbiol.
44
819-828
2002
1
-
-
-
-
-
3
-
-
2
1
1
-
4
-
-
-
-
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
2
1
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641623
Plaxton
Molecular and regulatory prope ...
Brassica napus
Arch. Biochem. Biophys.
400
54-62
2002
1
-
-
-
-
-
3
2
2
-
2
-
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
2
2
-
2
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641607
Nishikawa
Purification and characterizat ...
Lethenteron camtschaticum
Comp. Biochem. Physiol. B
128
159-164
2001
-
-
-
-
-
-
1
3
-
-
2
-
-
2
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
2
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641615
Asanuma
Molecular characterization, en ...
Selenomonas ruminantium
Microbiology
147
681-690
2001
3
-
-
-
-
-
1
4
-
4
3
-
-
3
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
4
-
4
3
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641617
Wang
Human erythrocyte pyruvate kin ...
Homo sapiens
Blood
98
3113-3120
2001
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641619
Knowles
Structural and regulatory prop ...
Synechococcus sp.
J. Biol. Chem.
276
20966-20972
2001
3
-
-
-
-
-
5
2
-
5
2
-
-
7
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
5
-
2
-
5
2
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641622
Zervoudakis
-
Pyruvate kinase activity in cr ...
Amaranthus sp., Cynodon dactylon, Digitaria sanguinalis, Setaria verticillata, Sorghum halepense
Russ. J. Plant Physiol.
48
171-175
2001
-
-
-
-
-
-
-
5
-
-
-
-
-
5
-
-
-
-
-
5
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
5
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721449
Labes
Sugar utilization in the hyper ...
Archaeoglobus fulgidus, Archaeoglobus fulgidus 7324
Arch. Microbiol.
176
329-338
2001
-
-
-
-
-
-
-
2
-
-
-
1
-
9
-
-
-
-
-
2
2
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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1
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2
2
-
2
-
1
-
-
-
-
-
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-
-
1
1
-
-
-
641601
Schramm
Pyruvate kinase of the hyperth ...
Thermoproteus tenax
J. Bacteriol.
182
2001-2009
2000
-
-
1
-
-
-
-
1
-
3
2
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7
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1
1
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-
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1
1
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1
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1
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3
2
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1
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1
1
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-
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-
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641602
Smith
Purification and characterizat ...
Brassica napus
Eur. J. Biochem.
267
4477-4485
2000
1
-
-
-
-
-
4
3
2
3
1
-
-
2
-
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1
-
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-
1
-
1
1
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1
-
1
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1
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4
-
3
2
3
1
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1
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1
-
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
641603
Turner
-
Purification and characterizat ...
Musa cavendishii
Biochem. J.
352
875-882
2000
-
-
-
-
-
-
2
2
-
3
2
-
-
1
-
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1
1
-
1
1
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1
1
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-
1
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8
-
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-
-
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2
8
2
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3
2
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1
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1
1
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641612
Singh
Purification and characterizat ...
Brassica rapa subsp. oleifera
Indian J. Biochem. Biophys.
37
51-58
2000
3
-
-
-
-
-
6
2
2
3
3
-
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2
-
-
1
1
-
2
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2
1
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1
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3
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6
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2
2
3
3
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1
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2
-
-
2
1
-
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-
1
-
-
-
-
-
-
-
-
-
641626
Fothergill-Gillmore
Leishmania pyruvate kinase: th ...
Leishmania sp.
Biochem. Soc. Trans.
28
186-190
2000
-
-
-
1
-
-
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4
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-
-
-
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-
-
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641605
Nairn
Purification and characterizat ...
Schizosaccharomyces pombe
Protein Expr. Purif.
14
247-253
1998
1
-
-
-
-
-
-
1
-
2
2
-
-
3
-
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1
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2
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2
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1
2
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-
-
-
-
-
-
-
-
-
-
641606
Ernest
Pyruvate kinase of Trypanosoma ...
Trypanosoma brucei
Protein Expr. Purif.
13
373-382
1998
1
-
-
-
2
-
-
1
-
-
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-
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3
-
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1
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2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
678997
Palop
Inactivation of enzymes within ...
Bacillus megaterium
Can. J. Microbiol.
44
465-470
1998
-
-
-
-
-
-
4
-
-
-
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2
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1
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1
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4
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-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
641609
Vetter
-
Catalytic properties of two py ...
Meganyctiphanes norvegica
Comp. Biochem. Physiol. A
116A
1-10
1997
1
-
-
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1
4
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1
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-
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2
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1
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1
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1
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4
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641621
Boles
Characterization of a glucose- ...
Saccharomyces cerevisiae
J. Bacteriol.
179
2987-2993
1997
1
-
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2
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1
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-
-
-
-
-
-
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-
-
-
-
-
-
-
-
641624
Arai
Purification and characterizat ...
Microbispora rosea subsp. aerata
Biosci. Biotechnol. Biochem.
61
40-45
1997
1
-
-
-
-
-
-
-
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2
-
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2
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1
-
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1
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1
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1
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1
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2
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1
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-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
641625
Zervoudakis
-
Characterization of purified l ...
Cynodon dactylon
Physiol. Plant.
101
563-569
1997
-
-
-
-
-
-
-
2
-
-
2
-
-
1
-
1
1
-
-
-
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1
1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
2
-
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2
-
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1
1
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641611
Ambasht
Purification, characterisation ...
Vigna radiata
Indian J. Biochem. Biophys.
33
184-194
1996
-
-
-
-
-
-
1
6
-
3
-
-
-
3
-
-
1
-
-
-
-
-
1
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-
-
-
-
-
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-
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-
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-
-
-
-
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1
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6
-
3
-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641616
Hu
Purification and characterizat ...
Ricinus communis
Arch. Biochem. Biophys.
333
298-307
1996
-
-
-
-
-
-
3
4
3
3
2
-
-
3
-
-
1
-
-
3
1
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
4
3
3
2
-
-
-
-
1
-
3
1
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
641608
Farrar
Purification and properties of ...
Sus scrofa
Int. J. Biochem. Cell Biol.
27
1145-1151
1995
1
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
1
1
-
1
1
-
1
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
641610
Tanaka
Molecular cloning of the genes ...
Bacillus licheniformis, Escherichia coli, Sporosarcina psychrophila
Biosci. Biotechnol. Biochem.
59
1536-1542
1995
5
-
2
-
-
-
2
-
-
-
3
-
-
7
-
-
-
2
-
-
2
-
3
2
1
-
-
-
1
-
-
-
-
-
-
5
-
2
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
2
-
3
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
641618
Wan
Import characteristics of a le ...
Ricinus communis
J. Biol. Chem.
270
16731-16739
1995
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641627
Mattevi
Crystal structure of Escherich ...
Escherichia coli
Structure
3
729-741
1995
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641514
Isani
-
Kinetic properties of liver an ...
Dicentrarchus labrax
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
107
617-624
1994
1
-
-
-
-
-
5
-
-
2
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
5
-
-
-
2
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641579
Ernest
Cloning and sequence analysis ...
Trypanoplasma borreli, Trypanoplasma borreli K-100
Biochem. Biophys. Res. Commun.
201
727-732
1994
1
-
1
-
-
-
-
1
-
-
1
-
-
6
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727725
Yu
Pathway of glycogen metabolism ...
Methanococcus maripaludis
J. Bacteriol.
176
325-332
1994
-
-
-
-
-
-
-
-
-
2
-
-
-
5
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
641513
De Graaff
Isolation and characterization ...
Aspergillus nidulans, Aspergillus niger
Curr. Genet.
22
21-27
1992
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641515
Zamora
-
Purification and properties of ...
Chaenocephalus aceratus
Int. J. Biochem.
24
1833-1840
1992
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
641516
Wu
-
Purification and characteizati ...
Chlamydomonas reinhardtii
J. Phycol.
28
472-481
1992
4
-
-
-
-
-
9
2
-
3
2
-
-
1
-
-
1
1
-
1
1
-
8
1
-
-
1
-
1
-
-
1
-
-
-
4
-
-
1
-
-
-
-
9
-
2
-
3
2
-
-
-
-
1
-
1
1
-
8
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
641517
Callens
Some kinetic properties of pyr ...
Trypanosoma brucei
Mol. Biochem. Parasitol.
50
235-243
1992
7
-
-
-
-
-
-
1
-
2
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
641583
Strick
The isolation and characteriza ...
Yarrowia lipolytica
Gene
118
65-72
1992
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641590
Potter
-
Purification and properties of ...
Thermoplasma acidophilum
FEMS Microbiol. Lett.
94
235-240
1992
-
-
-
-
-
1
-
2
-
-
1
-
-
1
-
-
1
-
-
1
1
-
1
1
1
-
3
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
1
-
1
1
-
1
1
1
-
3
-
1
-
-
-
-
-
-
-
-
-
744177
Schäfer
-
Maltose fermentation to aceta ...
Pyrococcus furiosus
Arch. Microbiol.
158
188-202
1992
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
641518
Kiffmeyer
Purification and properties of ...
Sus scrofa
J. Protein Chem.
10
585-591
1991
2
-
-
-
-
-
-
-
-
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2
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3
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-
1
-
-
3
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
3
-
-
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
641519
Singh
Purification and kinetic prope ...
Brochothrix thermosphacta
Biochem. Int.
25
35-45
1991
2
-
-
-
-
-
2
-
-
-
1
-
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641520
Schmidt-Base
Crystallization and preliminar ...
Oryctolagus cuniculus
Proteins Struct. Funct. Genet.
11
153-157
1991
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-
1
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1
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3
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2
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1
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641521
Agboola
-
Purification and some properti ...
Kinixys erosa
Comp. Biochem. Physiol. B
99
513-521
1991
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-
-
-
-
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1
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1
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1
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1
1
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641571
Ruyters
-
Oligomeric forms of pyruvate k ...
Parachlorella kessleri
Z. Naturforsch. C
46
416-422
1991
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-
-
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1
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3
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1
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1
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1
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1
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1
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1
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3
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1
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1
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1
-
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-
641522
Marshall
Purification and properties of ...
Dictyostelium discoideum
Biochem. Int.
21
615-622
1990
1
-
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2
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1
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3
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1
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1
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1
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1
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2
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1
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1
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1
-
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1
1
-
-
-
-
-
-
-
-
-
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-
-
-
641569
Plaxton
Purification of leucoplast pyr ...
Ricinus communis
Plant Physiol.
94
1528-1534
1990
-
-
-
-
-
-
-
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3
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1
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6
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6
1
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1
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1
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3
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1
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6
1
-
1
-
1
-
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-
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-
-
-
-
-
-
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-
641523
Gupta
-
Properties of pyruvate kinase ...
Cicer arietinum
Plant Physiol. Biochem.
27
703-711
1989
4
-
-
-
-
-
7
2
-
2
1
1
-
1
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1
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1
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5
-
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1
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5
-
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4
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5
-
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7
-
2
-
2
1
1
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1
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1
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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641524
Terlecki
Purification and properties of ...
Bos taurus
Int. J. Biochem.
21
1053-1060
1989
1
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2
2
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1
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2
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1
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2
1
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1
1
1
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1
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1
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1
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1
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2
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2
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1
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1
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2
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
641525
Wakita
Enzymatic properties of pyruva ...
Entodinium sp.
Int. J. Biochem.
21
777-781
1989
1
-
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1
3
-
2
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3
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1
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3
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1
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1
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1
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3
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1
-
-
-
-
-
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-
-
-
-
-
-
-
-
641526
Calomenopoulou
Purification and regulatory pr ...
Pigeon
Comp. Biochem. Physiol. B
93
697-706
1989
3
-
-
-
-
-
3
2
-
1
1
-
-
1
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1
-
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1
1
-
1
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-
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3
-
3
-
-
-
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3
-
2
-
1
1
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
641575
Lin
Pyruvate kinase isozymes from ...
Monoraphidium minutum
Arch. Biochem. Biophys.
269
219-227
1989
-
-
-
-
-
-
1
-
1
2
3
-
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5
-
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1
-
-
1
1
1
1
1
1
-
2
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-
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-
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1
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1
2
3
-
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1
-
1
1
1
1
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
641576
Lin
Pyruvate kinase isozymes from ...
Monoraphidium minutum
Arch. Biochem. Biophys.
269
228-238
1989
5
-
-
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-
-
17
4
4
6
-
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-
2
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-
-
-
-
1
-
-
10
-
1
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2
2
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-
-
5
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17
-
4
4
6
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1
-
-
10
-
1
-
-
-
2
2
-
-
-
-
-
-
-
-
641577
Knowles
-
Purification of a novel pyruva ...
Monoraphidium minutum
FEBS Lett.
259
130-132
1989
-
-
-
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1
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2
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1
1
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1
1
1
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1
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1
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1
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641582
Duncan
-
Properties of pyruvate kinase ...
Schizosaccharomyces pombe
Biochem. Soc. Trans.
17
560-561
1989
1
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1
-
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1
2
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1
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1
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3
1
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1
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1
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1
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1
2
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1
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1
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641527
Etges
Purification and characterizat ...
Leishmania major
Mol. Biochem. Parasitol.
27
281-289
1988
1
-
-
-
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5
1
-
2
2
2
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2
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1
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2
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3
1
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-
2
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1
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5
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1
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2
2
2
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1
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2
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-
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
641568
Plaxton
Purification of pyruvate kinas ...
Ricinus communis
Plant Physiol.
86
1064-1069
1988
1
-
-
-
-
1
-
-
2
2
3
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3
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1
-
-
3
1
1
1
1
1
-
-
-
-
-
-
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1
-
-
-
-
-
1
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2
2
3
-
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1
-
3
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641580
Kester
A rapid purification procedure ...
Aspergillus nidulans
Can. J. Microbiol.
34
1154-1158
1988
-
-
-
-
-
-
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1
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2
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2
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1
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2
1
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1
1
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1
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1
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2
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1
-
2
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
641558
Muirhead
Crystallographic studies on th ...
Felis catus
Biochem. Soc. Trans.
15
996-999
1987
-
-
-
1
-
-
-
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2
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1
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4
-
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1
-
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-
-
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2
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-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
641581
Hohn
Purification and properties of ...
Mucor racemosus
J. Bacteriol.
169
3525-3530
1987
-
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-
-
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5
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3
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1
-
-
1
2
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
5
-
-
-
-
1
-
1
2
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641588
Garcia-Olalla
Purification and kinetic prope ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
Biochem. J.
241
573-581
1987
1
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1
2
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2
4
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43
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1
-
-
1
1
3
2
1
1
-
3
-
1
1
1
1
-
-
-
1
-
-
1
-
-
-
-
1
-
2
-
2
4
-
-
-
-
1
-
1
1
3
2
1
1
-
3
-
1
1
1
-
-
-
-
-
-
-
3241
Pawluk
Isolation and properties of th ...
Zymomonas mobilis
Biochem. J.
238
275-281
1986
3
-
-
-
-
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-
1
-
1
2
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3
-
-
1
-
-
1
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
1
-
1
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641528
Carvajal
-
Properties of pyruvate kinase ...
Concholepas concholepas
Comp. Biochem. Physiol. B
85
577-580
1986
2
-
-
-
-
-
1
-
-
2
1
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-
1
-
-
1
-
-
2
-
-
1
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-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
2
1
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-
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-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641529
Kobayashi
Physical and catalytic propert ...
Sus scrofa
Arch. Oral Biol.
31
559-563
1986
1
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-
-
-
-
1
3
-
-
2
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-
2
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1
-
-
3
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
3
-
-
2
-
-
-
-
1
-
3
-
-
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
641530
Sand
Kinetic properties of liver py ...
Platichthys flesus
Comp. Biochem. Physiol. B
84
91-96
1986
-
-
-
-
-
-
1
1
-
-
-
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-
1
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-
1
-
-
1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
1
-
-
-
-
-
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-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641561
Guy
-
Studies on the inhibition of t ...
Oryctolagus cuniculus
Biochem. Soc. Trans.
14
152
1986
-
-
-
-
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1
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1
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1
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-
1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641584
Sakai
Purification and properties of ...
Geobacillus stearothermophilus
J. Biochem.
99
1157-1167
1986
5
-
-
-
-
-
7
-
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8
3
-
-
2
-
1
1
1
-
1
1
3
11
1
1
-
3
-
2
2
1
4
-
-
-
5
-
-
4
-
-
-
-
7
-
-
-
8
3
-
-
-
1
1
-
1
1
3
11
1
1
-
3
-
2
2
1
-
-
-
-
-
-
-
641531
Michaelidis
-
Purification, catalytic and re ...
Patella caerulea
Comp. Biochem. Physiol. B
82
405-412
1985
1
-
-
-
-
-
2
1
-
-
1
-
-
1
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641532
Chrispeels
-
Purification and characterizat ...
Cardium tuberculatum
Comp. Biochem. Physiol. B
82
162-172
1985
1
-
-
-
-
-
3
2
-
4
2
1
-
1
-
-
1
-
-
2
1
-
4
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
2
-
4
2
1
-
-
-
1
-
2
1
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641533
Cortesi
-
Characterization of pyruvate k ...
Chamelea gallina, Scapharca inaequivalvis
Comp. Biochem. Physiol. B
81
123-129
1985
-
-
-
-
-
-
5
-
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5
-
-
-
2
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-
1
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
5
-
-
-
-
-
1
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641534
Storey
-
Kinetic and regulatory propert ...
Periplaneta americana
J. Comp. Physiol. B
155
339-345
1985
1
-
-
-
-
-
3
2
-
3
1
-
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
3
-
2
-
3
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
641536
Busto
-
Some kinetic properties of pyr ...
Phycomyces blakesleeanus
Int. J. Biochem.
17
253-257
1985
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
641537
Roberts
The purification and kinetic c ...
Anguilla rostrata
Comp. Biochem. Physiol. B
80
51-56
1985
1
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2
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1
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2
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1
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641564
Srivastava
Purification and properties of ...
Rattus norvegicus
Arch. Biochem. Biophys.
236
703-713
1985
1
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3
4
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1
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3
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1
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3
1
1
1
1
1
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2
2
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1
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3
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4
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1
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1
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3
1
1
1
1
1
-
-
-
2
2
-
-
-
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-
-
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641566
Plaxton
Purification and properties of ...
Busycotypus canaliculatum
Arch. Biochem. Biophys.
243
195-205
1985
3
-
-
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1
5
3
-
5
4
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3
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1
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2
1
1
1
1
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1
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3
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1
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5
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3
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5
4
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1
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2
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641587
Evans
-
Partial purification and prope ...
Rhodotorula toruloides, Rhodotorula toruloides CBS 14
Can. J. Microbiol.
31
479-484
1985
2
-
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6
2
-
3
1
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2
-
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1
1
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2
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1
1
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1
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2
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1
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6
-
2
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3
1
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1
1
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2
-
-
-
-
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1
1
-
-
-
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-
-
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641535
Lesicki
-
Properties of pyruvate kinase ...
Tenebrio molitor
Bull. Soc. Amis Sci. Lett,Poznan,Ser. D
24
31-38
1984
-
-
-
-
-
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2
5
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1
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2
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1
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2
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5
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2
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1
-
-
-
-
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1
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-
-
-
-
-
-
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641538
Sand
Purification and properties of ...
Platichthys flesus
Comp. Biochem. Physiol. B
79
473-479
1984
-
-
-
-
-
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1
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3
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1
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1
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1
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3
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1
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1
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1
-
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-
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-
-
-
-
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641539
Kaloyianni-Dimitriades
Purification, catalytic and re ...
Pelophylax ridibundus
Comp. Biochem. Physiol. B
79
245-250
1984
1
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2
2
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3
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1
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2
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1
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2
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1
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1
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2
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2
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3
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1
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1
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2
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3
1
-
-
-
-
-
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-
-
-
-
-
-
-
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641540
Sanchez
-
Purification and properties of ...
Mytilus galloprovincialis
Comp. Biochem. Physiol. B
78
873-879
1984
-
-
-
-
-
-
1
1
-
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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-
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-
-
-
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-
-
-
-
-
-
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641541
Carpene
-
Characteristics of pyruvate ki ...
Chamelea gallina
Comp. Biochem. Physiol. B
77
693-698
1984
-
-
-
-
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3
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2
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1
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1
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1
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1
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3
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2
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1
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1
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1
-
-
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-
-
-
-
-
-
-
-
-
-
-
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641565
Plaxton
Purification and properties of ...
Busycotypus canaliculatum
Eur. J. Biochem.
143
257-265
1984
2
-
-
-
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-
18
2
-
4
3
-
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3
-
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1
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3
2
1
1
1
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2
1
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2
-
2
-
-
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18
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2
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4
3
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1
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3
2
1
1
1
-
-
-
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2
1
-
2
-
-
-
-
-
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641570
Baysdorfer
Spinach pyruvate kinase isofor ...
Saccharomyces cerevisiae, Spinacia oleracea
Plant Physiol.
74
374-379
1984
3
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-
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6
6
-
4
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4
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1
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1
2
4
5
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1
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2
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1
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1
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3
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1
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6
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6
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4
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1
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1
2
4
5
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
641593
Meixner-Monori
Pyruvate kinase from Aspergill ...
Aspergillus niger
Can. J. Microbiol.
30
16-22
1984
-
-
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-
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3
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1
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1
-
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-
-
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-
-
-
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-
-
-
-
641586
Kapoor
Purification and properties of ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis CDC 46
Arch. Biochem. Biophys.
225
320-330
1983
1
-
-
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-
1
8
2
-
6
1
-
-
3
-
-
1
1
-
1
1
1
8
1
1
-
2
-
1
1
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1
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-
-
-
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1
-
8
-
2
-
6
1
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1
-
1
1
1
8
1
1
-
2
-
1
1
-
-
-
-
-
-
-
-
654470
Boiteux
Analysis of progress curves. I ...
Escherichia coli
Biochem. J.
211
631-640
1983
-
-
-
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1
1
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2
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1
-
4
-
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
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641542
Fields
-
Some catalytic and regulatory ...
Nautilus pompilius
Pac. Sci.
36
315-324
1982
-
-
-
-
-
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3
2
-
2
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1
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1
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2
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1
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3
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2
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2
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1
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2
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1
-
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-
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-
-
-
-
-
-
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641543
Leon
-
Purification and characterizat ...
Concholepas concholepas
Comp. Biochem. Physiol. B
72
65-69
1982
1
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2
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2
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1
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2
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1
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1
1
-
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-
-
-
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-
-
-
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-
-
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641553
Kahn
-
Pyruvate kinases from human er ...
Homo sapiens
Methods Enzymol.
90
131-140
1982
1
-
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-
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2
1
1
2
2
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1
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1
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2
2
1
1
1
2
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1
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2
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1
1
2
2
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1
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2
2
1
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
641554
Cardenas
-
Pyruvate kinase from bovine mu ...
Bos taurus
Methods Enzymol.
90
140-149
1982
1
-
-
-
-
-
-
2
-
4
3
1
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1
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1
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1
2
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3
2
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-
-
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3
-
1
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-
-
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2
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4
3
1
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1
-
1
2
-
3
2
-
-
-
-
-
-
-
3
-
-
-
-
-
-
641555
Imamura
-
Pyruvate kinase isozymes from ...
Rattus norvegicus
Methods Enzymol.
90
150-165
1982
1
-
-
1
-
2
6
8
-
1
-
-
-
1
-
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1
-
-
9
5
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2
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1
-
-
-
-
-
-
-
-
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1
-
-
-
1
-
2
-
6
-
8
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1
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-
-
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1
-
9
5
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641556
Crow
-
Pyruvate kinase from Streptoco ...
Lactococcus lactis, Lactococcus lactis C10
Methods Enzymol.
90
165-170
1982
10
-
-
-
-
-
4
1
-
7
1
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-
4
-
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1
-
-
1
1
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4
-
1
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-
-
1
-
-
-
-
-
-
10
-
-
-
-
-
-
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4
-
1
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7
1
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1
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1
1
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
641557
Malcovati
-
AMP- and fructose 1,6-bisphosp ...
Escherichia coli
Methods Enzymol.
90
170-179
1982
3
-
-
-
-
-
-
-
-
-
4
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-
1
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1
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1
1
2
1
1
1
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1
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1
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-
-
3
-
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1
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-
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4
-
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1
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1
1
2
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
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641562
Schering
Purification and properties of ...
Rattus norvegicus
Biochim. Biophys. Acta
717
337-347
1982
1
-
-
-
-
-
9
4
-
2
1
-
-
4
-
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1
-
-
2
1
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5
1
1
-
-
-
1
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-
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1
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1
-
-
-
-
-
-
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9
-
4
-
2
1
-
-
-
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1
-
2
1
-
5
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
641563
Nagao
Difference in physical and che ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
104
713-719
1982
-
-
-
-
-
-
-
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1
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2
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1
-
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2
1
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1
1
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-
-
-
-
-
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-
-
-
-
-
-
-
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1
-
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1
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2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641585
De Médicis
-
Purification and properties of ...
Halobacterium salinarum, Halobacterium salinarum 9
Biochim. Biophys. Acta
708
57-67
1982
3
-
-
-
-
2
4
-
-
5
2
-
-
2
-
-
1
1
1
1
1
-
4
1
-
-
4
-
-
-
1
1
-
-
-
3
-
-
1
-
-
2
-
4
-
-
-
5
2
-
-
-
-
1
1
1
1
-
4
1
-
-
4
-
-
-
1
-
-
-
-
-
-
-
641589
Abe
Purification and properties of ...
Streptococcus mutans, Streptococcus mutans JC2
J. Bacteriol.
149
299-305
1982
6
-
-
-
-
2
1
7
-
9
2
-
-
4
-
-
1
-
-
1
1
1
12
1
-
-
-
-
1
-
-
2
-
-
-
6
-
-
2
-
-
2
-
1
-
7
-
9
2
-
-
-
-
1
-
1
1
1
12
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641544
Flynn
Some kinetic properties of pyr ...
Trypanosoma brucei
Mol. Biochem. Parasitol.
4
95-106
1981
1
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
1
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-
-
-
-
-
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-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641545
Wu
Purification and properties of ...
Canis lupus familiaris
Int. J. Biochem.
13
147-152
1981
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
1
-
-
1
-
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641560
Ibsen
Purification and properties of ...
Mus musculus
Biochemistry
20
1497-1506
1981
1
-
-
-
-
-
-
1
1
1
7
-
-
2
-
-
1
-
-
2
2
-
1
1
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
1
1
1
7
-
-
-
-
1
-
2
2
-
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
641546
Guderley
Catalytic and regulatory prope ...
Metacarcinus magister
J. Exp. Zool.
212
461-469
1980
1
-
-
-
-
-
6
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
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6
-
2
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-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641547
Guderley
-
A study of the catalytic prope ...
Oncorhynchus kisutch
J. Exp. Zool.
212
269-277
1980
-
-
-
-
-
-
3
1
-
1
-
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-
1
-
-
-
-
-
2
-
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1
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-
-
-
-
-
-
-
-
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-
-
-
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-
-
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3
-
1
-
1
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-
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2
-
-
1
-
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-
-
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-
-
-
-
-
-
-
-
641548
Guderley
Pyruvate kinases of salmon: pu ...
Oncorhynchus kisutch
J. Exp. Zool.
211
185-198
1980
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641567
Ireland
Characterization and kinetics ...
Ricinus communis
Plant Physiol.
65
1188-1193
1980
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2
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641578
Flynn
Purification and characterizat ...
Trypanosoma brucei
Arch. Biochem. Biophys.
200
401-409
1980
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641594
Kapoor
Studies of the structure--func ...
Neurospora crassa
Can. J. Microbiol.
26
613-621
1980
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641596
Chuang
Structural and regulatory prop ...
Pseudomonas citronellolis
J. Biol. Chem.
254
8434-8441
1979
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641600
Smart.
-
Regulation of pyruvate kinase ...
Propionibacterium freudenreichii subsp. shermanii
Arch. Microbiol.
122
281-288
1979
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641559
Stammers
Structure of cat muscle pyruva ...
Felis catus
Biochem. Soc. Trans.
5
654-657
1977
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641549
Tuominen
-
Pyruvate kinase of Bacillus li ...
Bacillus licheniformis, Bacillus licheniformis A-5
Methods Enzymol.
42C
157-166
1975
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641550
Flanders
-
Isozymes of pyruvate kinase fr ...
Rana pipiens
Methods Enzymol.
42C
166-175
1975
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641551
Aust
-
Pyruvate kinase from yeast (Sa ...
Saccharomyces cerevisiae, Saccharomyces pastorianus
Methods Enzymol.
42C
176-182
1975
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4
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641552
Staal
-
Human erythrocyte pyruvate kin ...
Homo sapiens
Methods Enzymol.
42C
182-186
1975
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641573
Besford
-
Properties of pyruvate kinase ...
Solanum lycopersicum
Phytochemistry
14
677-682
1975
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641592
Kapoor
Subunit structure and some pro ...
Neurospora crassa
Can. J. Biochem.
53
109-119
1975
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641598
Gibriel
Investigation into pyruvate ki ...
Escherichia coli
Microbios
12
179-197
1975
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641599
Ng
Purification and regulatory pr ...
Veillonella parvula
J. Bacteriol.
122
1274-1282
1975
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641597
Collins
Pyruvate kinase of Streptococc ...
Lactococcus lactis
J. Bacteriol.
120
52-58
1974
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641572
Kayne
-
Pyruvate kinase ...
Amylomyces rouxii, Antarctic fish, Azotobacter vinelandii, Bacillus subtilis, Brevibacterium flavum, Cobitidae, Coprinopsis lagopus, Escherichia coli, Euglena gracilis, Halothiobacillus neapolitanus, Komagataeibacter xylinus, Mus musculus, Oncorhynchus mykiss, Oryctolagus cuniculus, Ostreidae, Paralithodes camtschaticus, Rana pipiens, Rattus norvegicus, Saccharomyces cerevisiae, Saccharomyces pastorianus, Schistocerca gregaria, Sus scrofa, Trypanosoma brucei
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
8
353-382
1973
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2
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23
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27
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27
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641574
Duggleby
The characterization and regul ...
Gossypium hirsutum
Arch. Biochem. Biophys.
155
270-277
1973
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641595
Terenzi
Two types of pyruvate kinase i ...
Amylomyces rouxii
Eur. J. Biochem.
18
342-350
1971
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