2.7.1.40: pyruvate kinase This is an abbreviated version! For detailed information about pyruvate kinase, go to the full flat file .
Reaction
ATP +
pyruvate =
ADP +
phosphoenolpyruvate
Synonyms ATP/pyruvate O'-phosphotransferase, ATP:pyruvate 2-O-phosphotransferase, CPK, CPK1, cPK2, cPK3, cPK4, cPK5, CTHBP, cytosolic pyruvate kinase, cytosolic thyroid hormone binding protein, EHI_098420, EhPK, EhPyk, erythroid (R-type) pyruvate kinase, fluorokinase, hL-PYK, hLPYK, hPKM2, K+-dependent PK, K+-independent PK, kinase, fluoro- (phosphorylating), kinase, pyruvate (phosphorylating), L-PK , L-PYK, liver PK, liver pyruvate kinase, M1-PK, M1-PYK, M2 pyruvate kinase, M2 type phosphoenolpyruvate kinase, M2-PK, M2-pyruvate kinase, M2-type pyruvate kinase, M2PK, mPKM2, MRSA PK, muscle PK, NCgl2008, NCgl2809, PAE0819, PfPYK, pfPyrK, phosphoenol transphosphorylase, phosphoenolpyruvate kinase, phosphoenolpyruvate: ADP phosphotransferase, PK-alphabeta1, PK-alphabeta2, PK-M1, PK-M2, PK-R, PK-S, PK1, PK3, PKC, PKC1, PKL, Pklr, PKM1, PKM2, PKp, ProTalphaK, PYK, PYK-I, Pyk1, Pyk2, PykA, PykF, PyKII, pyruvate kinase, pyruvate kinase 1, pyruvate kinase isoenzyme M2, pyruvate kinase isoform M2, pyruvate kinase isoforms 2, pyruvate kinase isozyme M1, pyruvate kinase isozyme type M2, pyruvate kinase M1, pyruvate kinase M2, pyruvate kinase M2 isoform, pyruvate kinase muscle isoform 2, pyruvate kinase muscle isozyme, pyruvate kinase type M2, pyruvate kinase type-II, pyruvate phosphotransferase, pyruvic kinase, R-type pyruvate kinase, R-type/L-type pyruvate kinase, red cell/liver pyruvate kinase, rM1-PYK, RMPK, RPK, Rv1617, SSO0981, TbrPYK, TCIL3000_10_12020, TcoPYK, THBP1, TuM2-PK, tumor cell specific pyruvate kinase isozyme M2, tumour M2-PK, tumour M2-pyruvate kinase, VcIIPK, VcIPK, VC_0485, VC_2008, VEG17, vegetative protein 17, vesicle-associated pyruvate kinase, YPK
ECTree
Turnover Number
Turnover Number on EC 2.7.1.40 - pyruvate kinase
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110
GDP
-
PykII, in 100 mM Tris-HCl,pH 8.5, at 37°C
131
IDP
-
PykII, in 100 mM Tris-HCl,pH 8.5, at 37°C
0.38 - 3204
phosphoenolpyruvate
additional information
additional information
-
0.16
ADP
pH 6.0, 45°C, in presence of Mg2+
0.2
ADP
pH 6.0, 45°C, in presence of Mn2+
1.53
ADP
cPK1, pH 7.5, 25°C
2.4
ADP
cPK3, pH 7.5, 25°C
3.05
ADP
cPK2, pH 7.5, 25°C
6.68
ADP
cPK5, pH 7.5, 25°C
15.3
ADP
-
purified enzyme, pH 7.0, 5°C
40.06
ADP
50°C, pH not specified in the publication
47.6
ADP
-
PykII, in 100 mM Tris-HCl,pH 8.5, at 37°C
52.85
ADP
65°C, pH not specified in the publication
56
ADP
-
purified enzyme, pH 7.0, 25°C/room temperature
58.78
ADP
70°C, pH not specified in the publication
80.29
ADP
80°C, pH not specified in the publication
360
ADP
-
purified enzyme, pH 7.0, 35°C
0.38
phosphoenolpyruvate
pH 6.0, 45°C, in presence of Mg2+
0.57
phosphoenolpyruvate
mutant PKM2G415R, pH 7.6, 37°C
1
phosphoenolpyruvate
pH 6.0, 45°C, in presence of Mn2+
1.53
phosphoenolpyruvate
cPK1, pH 7.5, 25°C
1.97
phosphoenolpyruvate
-
mutant enzyme T298A, activated be Tl+ and Mn2+
2.4
phosphoenolpyruvate
cPK3, pH 7.5, 25°C
3.05
phosphoenolpyruvate
cPK2, pH 7.5, 25°C
3.2
phosphoenolpyruvate
-
wild type enzyme, in the absence of K+, in 50 mM Mes-Tris, pH 6.0, at 25°C
4
phosphoenolpyruvate
cPK4, pH 7.5, 25°C
5.58
phosphoenolpyruvate
pH 7.0, 35°C
6.68
phosphoenolpyruvate
cPK5, pH 7.5, 25°C
9.79
phosphoenolpyruvate
pH 7.5, 37°C
12.1
phosphoenolpyruvate
-
pH 6.2, mutant enzyme T298C, Mn2+-activated
12.2
phosphoenolpyruvate
-
mutant enzyme T298C, activated be Tl+ and Mn2+
13.9
phosphoenolpyruvate
-
pH 6.2, mutant enzyme T298C, Mn2+- and fructose 1,6-bisphosphate activated
15.3
phosphoenolpyruvate
-
purified enzyme, pH 7.0, 5°C
21.5
phosphoenolpyruvate
-
mutant enzyme T298S, activated be Tl+ and Mn2+
39.67
phosphoenolpyruvate
50°C, pH not specified in the publication
41.3
phosphoenolpyruvate
-
pH 6.2, mutant enzyme T298C, Mg2+- and fructose 1,6-bisphosphate activated
50.12
phosphoenolpyruvate
65°C, pH not specified in the publication
56
phosphoenolpyruvate
-
purified enzyme, pH 7.0, 25°C/room temperature
58.4
phosphoenolpyruvate
-
pH 6.2, wild-type enzyme, Mn2+-activated
58.4
phosphoenolpyruvate
70°C, pH not specified in the publication
66
phosphoenolpyruvate
-
pH 6.2, wild-type enzyme, Mn2+- and fructose 1,6-bisphosphate activated
73.04
phosphoenolpyruvate
80°C, pH not specified in the publication
86.83
phosphoenolpyruvate
recombinant enzyme, pH 7.2, 25°C
104.33
phosphoenolpyruvate
recombinant enzyme, pH 7.2, 25°C
107.33
phosphoenolpyruvate
recombinant enzyme, pH 7.2, 25°C, in presence of fructose 1,6-bisphosphate
111.5
phosphoenolpyruvate
recombinant enzyme, pH 7.2, 25°C, in presence of fructose 2,6-bisphosphate
152
phosphoenolpyruvate
recombinant enzyme, pH 7.2, 25°C, in presence of fructose 2,6-bisphosphate
161
phosphoenolpyruvate
-
mutant enzyme E117K, in the absence of K+, in 50 mM Mes-Tris, pH 6.0, at 25°C
185
phosphoenolpyruvate
recombinant enzyme, pH 7.2, 25°C, in presence of fructose 1,6-bisphosphate
226
phosphoenolpyruvate
-
pH 6.2, wild-type enzyme, Mg2+ and fructose 1,6-bisphosphate activated
232
phosphoenolpyruvate
-
pH 6.2, wild-type enzyme, Mg2+-activated
360
phosphoenolpyruvate
-
purified enzyme, pH 7.0, 35°C
1182
phosphoenolpyruvate
-
wild type enzyme, in the presence of K+, in 50 mM Mes-Tris, pH 6.0, at 25°C
1736
phosphoenolpyruvate
-
mutant enzyme C9S/C268S, in the presence of 0.1 mM ribose 5'-phosphate, in 50 mM imidazole-HCl buffer, pH 7.2, 50 mM KCl, 7 mM MgCl2, 0.12 mM NADH, 0.02 mg/ml lactate dehydrogenase, 2 mM PEP, and 4 mM ADP, at 30°C
3204
phosphoenolpyruvate
-
wild type enzyme, in the presence of 0.1 mM ribose 5'-phosphate, in 50 mM imidazole-HCl buffer, pH 7.2, 50 mM KCl, 7 mM MgCl2, 0.12 mM NADH, 0.02 mg/ml lactate dehydrogenase, 2 mM PEP, and 4 mM ADP, at 30°C
additional information
additional information
the kinetic mechanism is random order with a rapid equilibrium
-
additional information
additional information
-
the kinetic mechanism is random order with a rapid equilibrium
-