2.1.1.361: [histone H4]-lysine20 N-methyltransferase
This is an abbreviated version!
For detailed information about [histone H4]-lysine20 N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.361
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2.1.1.361
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monomethylation
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methyltransferases
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trimethylation
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h4k20me
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crl4cdt2
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histone-modifying
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medicine
- 2.1.1.361
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monomethylation
- methyltransferases
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trimethylation
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h4k20me
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crl4cdt2
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histone-modifying
- medicine
Reaction
Synonyms
CG3307, EC 2.1.1.43, H4-K20-specific HMT, H4-K20-specific HMTase, H4-K20-specific methyltransferase, H4K20 di- and trimethyltransferase, H4K20 methyltransferase, H4K20 protein lysine methyltransferase, histone 4 K20 methyltransferase, histone H4 Lys 20 methyltransferase, histone H4 Lys 20 monomethyltransferase, histone H4 lysine 20 methyltransferase, histone H4 lysine 20 monomethyltransferase, histone H4 lysine20 trimethyltransferase, histone H4-K20 methyltransferase, histone H4-K20 trimethyltransferase, histone H4-lysine 20-specific methyltransferase, histone lysine methyltransferase, Hmt4-20, KMT5a, PKMT, Pr-Set7, PR-Set7/9, protein lysine methyltransferase, SET-4, SET8, SETD8, Suv4-20, Suv4-20h2
ECTree
2.1.1.361 [histone H4]-lysine20 N-methyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.361 - [histone H4]-lysine20 N-methyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20
3 S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20
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-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
S-adenosyl-L-methionine + a [histone H4]-N6,N6-dimethyl-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20
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-
-
?
S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20
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-
-
?
S-adenosyl-L-methionine + [p53]-L-lysine382
S-adenosyl-L-homocysteine + [p53]-N6-methyl-L-lysine382
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-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
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-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
highly specific substrate
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
-
-
?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
highly specific substrate
-
-
?
additional information
?
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the enzyme is completely inactive toward histone H4 with a K20L mutation
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-
?
additional information
?
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the proteolytic degradation of the enzyme is controlled by the SCFSlimb ligase complex
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-
?
additional information
?
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enzyme binding to the nucleosome protects it from degradation during the cell cycle. Full length enzyme has 3.8% of its histone methyltransferase activity on nucleosomes containing the H2A/E61A/ E64A/D90A/E92A mutations compared to wild type nucleosomes
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-
?
additional information
?
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the enzyme is completely inactive toward histone H4 with a K20L mutation
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-
?
additional information
?
-
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the enzyme is completely inactive toward histone H4 with a K20L mutation
-
-
?
