2.1.1.361: [histone H4]-lysine20 N-methyltransferase

This is an abbreviated version!
For detailed information about [histone H4]-lysine20 N-methyltransferase, go to the full flat file.

Reaction

Synonyms

CG3307, EC 2.1.1.43, H4-K20-specific HMT, H4-K20-specific HMTase, H4-K20-specific methyltransferase, H4K20 di- and trimethyltransferase, H4K20 methyltransferase, H4K20 protein lysine methyltransferase, histone 4 K20 methyltransferase, histone H4 Lys 20 methyltransferase, histone H4 Lys 20 monomethyltransferase, histone H4 lysine 20 methyltransferase, histone H4 lysine 20 monomethyltransferase, histone H4 lysine20 trimethyltransferase, histone H4-K20 methyltransferase, histone H4-K20 trimethyltransferase, histone H4-lysine 20-specific methyltransferase, histone lysine methyltransferase, Hmt4-20, KMT5a, PKMT, Pr-Set7, PR-Set7/9, protein lysine methyltransferase, SET-4, SET8, SETD8, Suv4-20, Suv4-20h2

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.361 [histone H4]-lysine20 N-methyltransferase

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Results	in table
2813	AA Sequence
2	Application
6	Cloned(Commentary)
1	Crystallization (Commentary)
295	Disease/ Diagnostics
4	Expression
22	General Information
5	Localization
2	Metals/Ions
3	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
23	Organism
2	Pathway
3	PDB ID
1	Posttranslational Modification
8	Protein Variants
6	Purification (Commentary)
1	Reaction
23	Reference
23	Source Tissue
34	Substrates and Products (Substrate)
6	Subunits
77	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.361 - [histone H4]-lysine20 N-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase

The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.