EC Number |
Recommended Name |
Localization |
GeneOntology No. |
Reference |
---|
3.1.3.64 | phosphatidylinositol-3-phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
716970 |
3.4.22.43 | cathepsin V |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
717374, 732591, 752678, 753117, 754753 |
3.4.21.71 | Pancreatic elastase II |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
718106 |
2.3.1.225 | protein S-acyltransferase |
lysosome |
enzyme class I |
GO:0005764 AmiGO QuickGO |
718835 |
3.5.1.23 | ceramidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171991, 668638, 696396, 700316, 719536, 733395, 734696, 752968, 753491, 753570, 754849, 754939, 754949 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
the enzyme is synthesized as a catalytically inactive 77-kDa precursor that is transported to the lysosomes via an adaptor protein-mediated pathway that involves conserved tyrosine- and dileucine-based lysosomal targeting signals in its C-terminal cytoplasmic domain with a contribution from a dileucine-based signal in the N-terminal cytoplasmic loop. In the lysosome, the precursor is cleaved into a 29-kDa N-terminal alpha-chain and a 48-kDa C-terminal beta-chain, and assembled into active 440-kDa oligomers. The subunits are held together by disulfide bonds between at least two cysteine residues, Cys123 and Cys434, in the lysosomal luminal loops of the enzyme. |
GO:0005764 AmiGO QuickGO |
719889 |
2.4.1.228 | lactosylceramide 4-alpha-galactosyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
722567, 722691 |
1.6.2.2 | cytochrome-b5 reductase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
724801 |
2.4.99.20 | 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
727868 |
3.1.3.21 | glycerol-1-phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
729762 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
protein carries mannose 6-phosphate, indicating lysosomal sorting |
GO:0005764 AmiGO QuickGO |
730022 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
63-kDa single-chain precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes. Proteolytically processed arylsulfatase G fragments of 34-, 18-, and 10-kDa are found in lysosomal fractions and lost their membrane association. Lysosomal transport of arylsulfatase G in the liver is independent of mannose 6-phosphate, sortilin, and Limp2. Mutation of glycosylation site N497 abrogates transport to lysosomes, due to impaired mannose 6-phosphate modification |
GO:0005764 AmiGO QuickGO |
730056 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
and heterophagolysosome of macrophages and mononuclear cells, two bands with strong immunoreactivity appear at molecular masses of 30 and 23 kDa |
GO:0005764 AmiGO QuickGO |
730727 |
3.4.21.93 | Proprotein convertase 1 |
lysosome |
in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation. Co-localization of PC1/3 and Toll-like receptor 4 is found upon lipopolysaccharide stimulation |
GO:0005764 AmiGO QuickGO |
732724 |
3.4.21.1 | chymotrypsin |
lysosome |
chymotrypsin colocalizes with the lysosomal marker protein LAMP1 |
GO:0005764 AmiGO QuickGO |
732856 |
3.5.1.23 | ceramidase |
lysosome |
of hepatocytes |
GO:0005764 AmiGO QuickGO |
733408 |
3.5.1.60 | N-(long-chain-acyl)ethanolamine deacylase |
lysosome |
the enzyme is believed to be transported by the mannose-6-phosphate pathway to the acidic late endosomes and/or lysosomes |
GO:0005764 AmiGO QuickGO |
734562 |
7.2.2.8 | P-type Cu+ transporter |
lysosome |
high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons |
GO:0005764 AmiGO QuickGO |
734662 |
2.3.1.43 | phosphatidylcholine-sterol O-acyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
736865 |
2.7.10.1 | receptor protein-tyrosine kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
738744 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
744236 |
6.1.1.4 | leucine-tRNA ligase |
lysosome |
co-localization of LRS and lysosome-associated membrane glycoprotein 2, LAMP2 |
GO:0005764 AmiGO QuickGO |
744247 |
7.2.1.3 | ascorbate ferrireductase (transmembrane) |
lysosome |
LCytb |
GO:0005764 AmiGO QuickGO |
744757 |
6.3.5.5 | carbamoyl-phosphate synthase (glutamine-hydrolysing) |
lysosome |
coexpression of small GTPase Rheb with CAD leads to increased accumulation of CAD on lysosomes |
GO:0005764 AmiGO QuickGO |
745319 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
isoform PPT1 |
GO:0005764 AmiGO QuickGO |
750869 |
7.2.2.12 | P-type Zn2+ transporter |
lysosome |
isoform ZntB is the main Zn2+ transporter of the lysosome |
GO:0005764 AmiGO QuickGO |
751181 |
3.1.1.4 | phospholipase A2 |
lysosome |
and lysosomal-related organelles |
GO:0005764 AmiGO QuickGO |
751276 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
the enzyme is localized in the lysosomal vacuolar system of both gill and digestive gland tissues |
GO:0005764 AmiGO QuickGO |
751444 |
3.4.22.34 | Legumain |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
649664, 650453, 650466, 650471, 650474, 651253, 668739, 668775, 670112, 696499, 701007, 708100, 717365, 731376, 731409, 752851, 752859, 753420, 755310 |
3.4.22.B60 | cathepsin L2 |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 753117 |
3.4.22.1 | cathepsin B |
lysosome |
stress stimulated secretion from the lysosomes |
GO:0005764 AmiGO QuickGO |
753138 |
3.4.22.B49 | cathepsin L1 |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
753379 |
3.4.22.27 | cathepsin S |
lysosome |
the enzyme contains a signal peptide (residues 1-17) |
GO:0005764 AmiGO QuickGO |
753606 |
3.5.1.26 | N4-(beta-N-acetylglucosaminyl)-L-asparaginase |
lysosome |
in the lysosomes, the C-termini of both alpha- and beta-subunits are trimmed by proteases, resulting in the mature form of AGA, though these trimming steps are not necessary for the catalytic activity of AGA |
GO:0005764 AmiGO QuickGO |
753910 |
3.5.1.60 | N-(long-chain-acyl)ethanolamine deacylase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 735061, 752354, 752355, 752811, 752960, 753248, 753491, 754356, 754610, 754903, 755270 |
3.4.14.9 | tripeptidyl-peptidase I |
lysosome |
a serine carboxyl lysosomal protease |
GO:0005764 AmiGO QuickGO |
-, 754998 |
3.4.14.9 | tripeptidyl-peptidase I |
lysosome |
microglial lysosomes |
GO:0005764 AmiGO QuickGO |
755266 |
2.3.2.23 | E2 ubiquitin-conjugating enzyme |
lysosome |
damaged |
GO:0005764 AmiGO QuickGO |
759124 |
2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
761580 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
761780 |