Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.4 extracted from

  • Choi, H.; Son, J.B.; Kang, J.; Kwon, J.; Kim, J.H.; Jung, M.; Kim, S.K.; Kim, S.; Mun, J.Y.
    Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane (2017), Biochem. Biophys. Res. Commun., 493, 1129-1135 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
BC-LI-0186 the interaction between RagD and LRS is disrupted by compound BC-LI-0186 inhibitong the translocation of the enzyme to the lysosome Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
lysosome co-localization of LRS and lysosome-associated membrane glycoprotein 2, LAMP2 Homo sapiens 5764
-
additional information location analysis of LRS with and without leucine, using stimulated emission depletion (STED) microscopy one of the super-resolution microscopy and transmission electron microscopy (TEM), reveals enzyme translocation to the lysosome from cytoplasm on addition of leucine. The translocation is inhibited by treatment with compound BC-LI-0186 disrupting the interaction between RagD and LRS Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
Homo sapiens
LRS
-
Homo sapiens

General Information

General Information Comment Organism
physiological function leucyl-tRNA synthetase (LRS) plays major roles in providing leucine-tRNA and activating mechanistic target of rapamycin complex 1 (mTORC1) through intracellular leucine sensing. mTORC1 activated by amino acids affects the influence on physiology functions including cell proliferation, protein synthesis and autophagy in various organisms. Crosstalk between leucine sensing, LRS translocation, RagD interaction, and mTORC1 activation, mTORC1 activation is related to LRS translocation dependent on leucine, analysis of relationship between mTORC1 activation and LRS translocation, overview Homo sapiens