Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BC-LI-0186 | the interaction between RagD and LRS is disrupted by compound BC-LI-0186 inhibitong the translocation of the enzyme to the lysosome | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
lysosome | co-localization of LRS and lysosome-associated membrane glycoprotein 2, LAMP2 | Homo sapiens | 5764 | - |
additional information | location analysis of LRS with and without leucine, using stimulated emission depletion (STED) microscopy one of the super-resolution microscopy and transmission electron microscopy (TEM), reveals enzyme translocation to the lysosome from cytoplasm on addition of leucine. The translocation is inhibited by treatment with compound BC-LI-0186 disrupting the interaction between RagD and LRS | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Leucyl-tRNA synthetase | - |
Homo sapiens |
LRS | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | leucyl-tRNA synthetase (LRS) plays major roles in providing leucine-tRNA and activating mechanistic target of rapamycin complex 1 (mTORC1) through intracellular leucine sensing. mTORC1 activated by amino acids affects the influence on physiology functions including cell proliferation, protein synthesis and autophagy in various organisms. Crosstalk between leucine sensing, LRS translocation, RagD interaction, and mTORC1 activation, mTORC1 activation is related to LRS translocation dependent on leucine, analysis of relationship between mTORC1 activation and LRS translocation, overview | Homo sapiens |