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Literature summary for 2.7.1.153 extracted from

  • Bhattacharya, S.; McElhanon, K.E.; Gushchina, L.V.; Weisleder, N.
    Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking (2016), Life Sci., 167, 39-45 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
Insulin
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin a PI3K inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
vesicle
-
 Homo sapiens 31982
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42336 AND P42338 AND P48736 AND O00329 subunits PIK3CA/p110alpha, PIK3CB/p110beta, PIK3CG/p110gamma, and PIK3CD/p110delta
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
pancreatic beta cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-4,5-bisphosphate 3-kinase
-
 Homo sapiens
PIK3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction treatment of cells with the PI3K inhibitor wortmannin, significantly attenuates GLUT4 exocytosis. Cellular deficiency of insulin signaling machineries dampens the expression of the insulin signaling proteins and obliterates downstream signaling mediated through the PI3K pathway Homo sapiens
metabolism analysis of the PI3K signaling cascade, overview Homo sapiens
physiological function phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Stimulation of PI3K can enhance lysosomal trafficking events to the plasma membrane. Insulin-induced activation of PI3K alters glucose transporter GLUT4 recycling, positive regulatory role for PI3K pathway in the GLUT4 receptor recycling process. PI3K demonstrates both positive and negative regulation of insulin release. The p110gamma subunit of type I PI3K is required to maintain a ready pool of insulin loaded vesicles for the recruitment of insulin granules in the islet beta-cells for release upon exocytic stimulation. PI3K C2alpha, a class II PI3K isoform, exerts signaling effects on insulin secretion from pancreatic beta-cells by promoting insulin loaded granules in insulinoma cells. PI3K is also known to contribute to glucose homeostasis by regulating beta-cell gene expression Homo sapiens