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Information on EC 5.1.1.17 - isopenicillin-N epimerase

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EC Tree
     5 Isomerases
         5.1 Racemases and epimerases
             5.1.1 Acting on amino acids and derivatives
                5.1.1.17 isopenicillin-N epimerase
IUBMB Comments
This enzyme contains pyridoxal phosphate. Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway (for pathway, click here).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
cefD2, IPN epimerase, isopenecillin N-CoA epimerase, isopenicillin N epimerase, isopenicillin N-CoA epimerase, PenN epimerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isopenicillin N = penicillin N
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forms part of the penicillin biosynthesis pathway; this enzyme contains pyridoxal phosphate, epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins, forms part of the penicillin biosynthesis pathway
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