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(DL)-homocysteine
H2S + ?
3-chloro-2-aminobutanoate
?
-
-
-
-
?
3-chloro-DL-alanine + H2O
NH3 + ?
-
-
-
?
alpha,beta-diaminopropionate
?
-
beta,gamma-elimination
-
-
?
beta-chloro-L-alanine + H2O
pyruvate + NH3 + HCl
-
-
-
-
?
beta-methylcystine
?
-
-
-
-
?
D-alanine + H2O
?
-
-
-
-
?
D-Cys + D-homoserine
D-cystathionine
-
-
-
?
D-Cys + L-homoserine
D-allocystathionine
DL-cystathionine
?
-
-
-
?
DL-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
DL-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
homocysteine
?
-
beta,gamma-elimination
-
-
?
L-alanine + H2O
?
-
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
L-Cys + D-homoserine
L-allocystathionine
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
L-cystathionine
2-oxobutyrate + L-cysteine + NH3
-
-
-
-
?
L-cystathionine
homocysteine + pyruvate + NH3
L-cystathionine
L-cysteine + 2-oxobutanoate + NH3
L-cystathionine
L-homocysteine + pyruvate + NH3
L-cystathionine
L-homoserine + L-cysteine
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
L-cystathionine + H2O
L-cysteine + ?
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
L-cysteine
H2S + NH3 + pyruvate
L-cysteine + H2O
H2S + pyruvate + NH3
L-cysteine + H2O
sulfide + NH3 + pyruvate
L-cysteine + L-cysteine
H2S + L-lanthionine
-
-
-
-
?
L-cysteine + L-cysteine
L-lanthionine + H2S
-
-
-
-
?
L-cystine + H2O
2 NH3 + 2 pyruvate + 2 hydrogen sulfide
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
L-cystine + H2O
NH3 + pyruvate + L-thiocysteine
L-cystine + H2O
pyruvate + NH3 + L-thiocysteine
-
-
-
-
?
L-cystine + H2O
thiocysteine + pyruvate + NH3
-
-
-
-
?
L-djenkolic acid + H2O
NH3 + ?
L-homocysteine + H2O
H2S + ?
-
-
-
-
?
L-homocysteine + H2O
NH3 + 2-oxobutanoate + H2S
-
-
-
-
?
L-homocysteine + L-cysteine
L-cystathionine + H2S
-
-
-
-
?
L-homocysteine + L-homocysteine
L-homolanthionine + H2S
-
-
-
-
?
L-homocystine
?
-
-
-
-
?
L-homoserine
2-oxobutyrate + NH3
-
the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term
-
-
?
L-homoserine + 2-mercaptoethanol
S-hydroxyethyl-L-homocysteine
-
8% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
L-homoserine + 4-mercaptobutanoate
S-carboxy-n-propyl-L-homocysteine
-
14% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + D-homocysteine
meso-homolanthionine
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
L-homoserine + H2O
H2O + NH3 + 2-oxobutanoate
-
-
-
-
?
L-homoserine + H2O
NH3 + ?
-
-
-
?
L-homoserine + L-Cys
L-cystathionine
L-homoserine + L-homocysteine
L-homolanthionine
L-homoserine + thioglycerol
S-(2,3-dihydroxypropyl)-L-homocysteine
-
5% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + thioglycolate
S-carboxymethyl-L-homocysteine
L-methionine + H2O
NH3 + ?
L-serine + H2O
NH3 + ?
-
-
-
?
lanthionine + H2O
NH3 + ?
131% of activity compared to cystathionine
-
?
mixed disulfide of L-cystine and L-homocystine
?
-
-
-
-
?
O-acetyl-L-homoserine
?
-
-
-
-
?
O-acetyl-L-homoserine + H2O
NH3 + ?
-
-
-
?
O-acetyl-L-serine + H2O
acetate + pyruvate + NH3
-
-
-
-
?
O-succinyl-L-homoserine
?
-
decomposed most rapidly of all the above substrates
-
-
?
O-succinyl-L-homoserine + H2O
NH3 + ?
-
-
-
?
S-(2-aminoethyl)-L-cysteine + H2O
NH3 + pyruvate + cysteamine
-
-
-
?
S-methyl-L-cysteine + H2O
NH3 + pyruvate + methyl mercaptan
-
-
-
?
seleno-L-methionine
methylselenol + 2-oxobutyrate + NH3
-
-
-
-
?
additional information
?
-
(DL)-homocysteine

H2S + ?
-
-
-
-
?
(DL)-homocysteine
H2S + ?
-
-
-
-
?
beta-chloro-L-Ala

?
-
alpha,beta-elimination
-
-
?
beta-chloro-L-Ala
?
-
alpha,gamma-elimination
-
-
?
D-Cys + L-homoserine

D-allocystathionine
-
-
-
-
?
D-Cys + L-homoserine
D-allocystathionine
-
-
-
?
D-Cys + L-homoserine
D-allocystathionine
-
at 318% of the activity with L-homocysteine and L-cysteine
-
?
D-Cys + L-homoserine
D-allocystathionine
-
gamma-replacement
-
-
?
D-Cys + L-homoserine
D-allocystathionine
-
gamma-replacement
-
?
djenkolic acid

?
-
L-djenkolic acid
-
-
?
djenkolic acid
?
-
-
-
-
?
djenkolic acid
?
-
-
-
-
?
djenkolic acid
?
-
beta,gamma-elimination
-
-
?
djenkolic acid
?
-
alpha,beta-elimination
-
-
?
djenkolic acid
?
-
alpha-gamma-elimination
-
-
?
DL-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
DL-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
DL-vinylglycine

?
-
alpha,beta-elimination
-
-
?
DL-vinylglycine
?
-
alpha,gamma-elimination
-
-
?
L-Cys

H2S + NH3 + pyruvate
-
alpha,beta-elimination
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
alpha,beta-elimination
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
?
L-Cys
H2S + NH3 + pyruvate
-
-
-
?
L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathionine

homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine
homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine

L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine

L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH3
-
alpha,beta-elimination
-
?
L-cystathionine
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O

?
-
-
-
-
?
L-cystathionine + H2O
?
-
-
-
-
?
L-cystathionine + H2O
?
-
-
-
-
?
L-cystathionine + H2O
?
-
-
-
-
?
L-cystathionine + H2O
?
-
-
-
-
?
L-cystathionine + H2O
?
-
beta,gamma-elimination
-
-
?
L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O

L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathionine + H2O

L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cysteine

H2S + NH3 + pyruvate
-
best substrate
-
?
L-cysteine
H2S + NH3 + pyruvate
-
best substrate
-
?
L-cysteine
H2S + NH3 + pyruvate
-
-
-
-
?
L-cysteine
H2S + NH3 + pyruvate
-
-
-
-
?
L-cysteine
H2S + NH3 + pyruvate
-
-
-
-
?
L-cysteine
H2S + NH3 + pyruvate
poor substrate
-
-
?
L-cysteine
H2S + NH3 + pyruvate
poor substrate
-
-
?
L-cysteine + H2O

H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O

sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
15% of activity compared to cystathionine
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
measurement of hydrogen sulfide production
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
measurement of hydrogen sulfide production
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
690781, 691828, 691972, 692207, 693818, 693936, 694398, 695079, 708133, 708300, 708411, 708627, 709212, 709676, 709778, 710627 -
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cystine

?
-
alpha,beta-elimination
-
-
?
L-cystine
?
-
alpha,beta-elimination
-
-
?
L-cystine
?
-
alpha,gamma-elimination
-
-
?
L-cystine + H2O

L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O
L-thiocysteine + pyruvate + NH3
-
-
-
-
?
L-cystine + H2O

NH3 + ?
133% of activity compared to cystathionine
-
?
L-cystine + H2O
NH3 + ?
-
-
-
?
L-cystine + H2O

NH3 + pyruvate + L-thiocysteine
-
-
-
?
L-cystine + H2O
NH3 + pyruvate + L-thiocysteine
-
-
-
-
?
L-cystine + H2O
NH3 + pyruvate + L-thiocysteine
-
-
-
-
?
L-djenkolic acid + H2O

NH3 + ?
24% of activity compared to cystathionine
-
?
L-djenkolic acid + H2O
NH3 + ?
-
-
-
?
L-homocysteine

?
-
-
-
?
L-homocysteine
?
-
-
-
-
?
L-homoserine

?
-
-
-
-
?
L-homoserine
?
-
beta,gamma-elimination
-
-
?
L-homoserine
?
-
alpha,gamma-elimination
-
-
?
L-homoserine + 2-mercaptopropionate

S-methylcarboxymethyl-L-homocysteine
-
-
-
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
-
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
gamma-replacement reaction
-
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
gamma-replacement reaction
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
73% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 3-mercaptopropionate

S-carboxyethyl-L-homocysteine
-
-
-
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
-
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
187% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
gamma-replacement reaction
-
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
gamma-replacement reaction
-
?
L-homoserine + D-homocysteine

meso-homolanthionine
-
-
-
-
?
L-homoserine + D-homocysteine
meso-homolanthionine
-
-
-
?
L-homoserine + D-homocysteine
meso-homolanthionine
-
gamma-replacement reaction, 368% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + H2O

2-oxobutanoate + NH3 + H2O
-
-
-
-
?
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
-
-
-
?
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
-
-
-
-
?
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
-
-
-
-
?
L-homoserine + L-Cys

L-cystathionine
-
-
-
?
L-homoserine + L-Cys
L-cystathionine
-
-
-
?
L-homoserine + L-Cys
L-cystathionine
-
-
-
?
L-homoserine + L-homocysteine

L-homolanthionine
-
-
-
-
?
L-homoserine + L-homocysteine
L-homolanthionine
-
-
-
?
L-homoserine + L-homocysteine
L-homolanthionine
-
gamma-replacement reaction, 314% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + thioglycolate

S-carboxymethyl-L-homocysteine
-
-
-
-
?
L-homoserine + thioglycolate
S-carboxymethyl-L-homocysteine
-
gamma-replacement reaction, 69% of the activity with L-homocysteine and L-Cys
-
?
L-Met

methanethiol + ?
-
alpha,gamma-elimination
-
?
L-Met
methanethiol + ?
-
-
-
-
?
L-methionine + H2O

NH3 + ?
-
-
-
?
L-methionine + H2O
NH3 + ?
-
-
-
?
Lanthionine

?
-
-
-
-
?
Lanthionine
?
-
beta,gamma-elimination
-
-
?
Lanthionine
?
-
meso-lanthionine
-
-
?
Lanthionine
?
-
L-lanthionine
-
-
?
Lanthionine
?
-
alpha,beta-elimination
-
-
?
Lanthionine
?
-
alpha,gamma-elimination
-
-
?
Lanthionine
?
-
DL-lanthionine
-
-
?
meso-cystine

?
-
-
-
-
?
S-aminoethyl-L-Cys

?
-
-
-
-
?
S-aminoethyl-L-Cys
?
-
-
-
-
?
S-aminoethyl-L-Cys
?
-
-
-
-
?
S-methyl-L-Cys

?
-
-
-
-
?
S-methyl-L-Cys
?
-
alpha,beta-elimination
-
-
?
additional information

?
-
-
enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic
-
?
additional information
?
-
-
enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic
-
?
additional information
?
-
-
hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine
-
-
?
additional information
?
-
-
enzyme responsible for amino acid catabolism
-
-
?
additional information
?
-
-
enzyme responsible for amino acid catabolism
-
-
?
additional information
?
-
-
activity decreases in the following order of substrates: L-cystathione, L-djenkolic, L-cystine, L-cysteine, L-methionine, L-serine
-
?
additional information
?
-
-
cysteine desulfhydrase in Rhodobacter sphaeroides can produce sulfide under aerobic conditions and precipitate metal sulfide complexes on the cell wall
-
-
?
additional information
?
-
-
enzyme is able to demethiolate methionine into methanethiol
-
-
?
additional information
?
-
-
enzyme is able to demethiolate methionine into methanethiol
-
-
?
additional information
?
-
-
the Streptomyces enzyme has a lower substrate specificity than the rat-liver one
-
-
?
additional information
?
-
-
hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine
-
-
?
additional information
?
-
-
no activity with L-methionine
-
-
?
additional information
?
-
-
responsible for the formation of nanocrystals
-
-
?
additional information
?
-
-
Glu333 of cystathionine gamma-lyase acts as a determinant of specificity, it interacts with the distal amine moiety of L-cystathionine, which is not present in the alternative substrate O-acetyl-L-serine. Catalytic efficiency of the yeast enzyme for alpha,gamma-elimination of O-succinyl-L-homoserine, which possesses a distal carboxylate, but lacks an amino group, is 300fold lower than that of the physiological L-cystathionine substrate and 260fold higher than that of L-Hcys, which lacks both distal polar moieties. Proposed polar contacts of the yCGL active site that interact with or are influenced by E48 and E333 overview
-
-
?
additional information
?
-
-
the Streptomyces enzyme has a lower substrate specificity than the rat-liver one
-
-
?
additional information
?
-
catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine
-
-
?
additional information
?
-
-
catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
L-cystathionine
2-oxobutyrate + L-cysteine + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
L-cysteine + H2O
H2S + pyruvate + NH3
L-cysteine + H2O
sulfide + NH3 + pyruvate
L-cystine + H2O
pyruvate + NH3 + L-thiocysteine
-
-
-
-
?
L-homoserine
2-oxobutyrate + NH3
-
the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term
-
-
?
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
-
-
-
?
additional information
?
-
L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O

L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O

H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O
H2S + pyruvate + NH3
-
-
-
-
?
L-cysteine + H2O

sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
additional information

?
-
-
enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic
-
?
additional information
?
-
-
enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic
-
?
additional information
?
-
-
hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine
-
-
?
additional information
?
-
-
enzyme responsible for amino acid catabolism
-
-
?
additional information
?
-
-
enzyme responsible for amino acid catabolism
-
-
?
additional information
?
-
-
cysteine desulfhydrase in Rhodobacter sphaeroides can produce sulfide under aerobic conditions and precipitate metal sulfide complexes on the cell wall
-
-
?
additional information
?
-
-
hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine
-
-
?
additional information
?
-
-
responsible for the formation of nanocrystals
-
-
?
additional information
?
-
catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine
-
-
?
additional information
?
-
-
catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(DL)-propargylglycine
-
chronical treatment of rats with CGL inhibitor (DL)-propargylglycine or cystathionine beta-synthase inhibitor aminooxyacetic acid or a combination of both. Only the rats with combination therapy show a decrease in urinary sulfate excretion rate, which is associated with an increase in mean arterial pressure. Urine flow and sodium excretion are also increased in combination group as consequent to the increase in mean arterial pressure. Glomerular filtration rate does not alter due to these treatments, renal blood flow is lowered only in the combination group compared to the control group
1,10-phenanthroline
-
2 mM, 20% inhibition
1-nitroso-2-naphthol-3,6-disulfonic acid
-
2 mM, 55% inhibition
2-(4-methoxyanilino)-2-oxoethyl-(2E)-2-[(3-fluoropyridin-2-yl)methylidene]hydrazine-1-carbodithioate
compound shows at least 400fold selectivity for CSEgamma over inhibition of cystathionine beta-synthase
2-(prop-2-yn-1-ylamino)acetic acid
-
-
3-methyl-2-benzothiazolinone
-
31% residual activity at 5 mM
3-Methyl-2-benzothiazolinone hydrazone
4-chloromercuribenzoate
-
-
5,5'-dithiobis(2-nitrobenzoate)
6-diazo-5-oxonorleucine
-
-
8-Hydroxyquinoline-5-sulfonic acid
-
2 mM, 13% inhibition
acetoacetate
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
AgNO3
-
alpha,beta-elimination L-homoserine
alpha-amino-gamma-aminooxybutanoate
-
-
aminoethoxyvinylglycine
-
-
beta,beta,beta-trifluoroalanine
beta-cyano-L-Ala
-
alpha,beta-elimination L-homoserine
beta-trifluoromethyl-D,L-Ala
-
i.e. 2-amino-4,4,4-trifluorobutanoate
CH3-Hg-S-Cys
-
the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor
Cys-S-Hg-S-Cys
-
the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor
D-glucose
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
DL-Penicillamine
-
3% residual activity at 5 mM
EDTA
-
2 mM, 13% inhibition
H2O2
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
HgCl2
-
a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase
iodoacetamide
-
22% residual activity at 2.5 mM
Isonicotinic acid hydrazide
-
-
L-aminoethoxyvinylglycine
-
-
L-beta-oxalyl amino-L-alanine
-
inhibition only after long exposure
N-prop-2-yn-1-ylglycine
-
-
NEM
-
0.05 mM, inhibition is partly relieved by 0.2 mM 2,3-dimercaptopropanol
O2
-
homogenized gills produces H2S enzymatically, and H2S production is inhibited by O2, whereas mitchondrial H2S consumption is O2 dependent
Sodium cyanide
-
alpha,beta-elimination, 1 mM, 82% inhibition
streptozotocin
-
livers from streptozotocin-treated type I diabetic rats have lower levels of enzyme protein expression, enzyme activity, reduced tissue H2S formation, and increased reactive oxygen species production compared with those of controls
3-Methyl-2-benzothiazolinone hydrazone

-
-
3-Methyl-2-benzothiazolinone hydrazone
-
-
5,5'-dithiobis(2-nitrobenzoate)

-
8 of the 12 -SH groups in native enzyme react reversibly. Cystathionine at high concentrations, partially relieves the inhibition
5,5'-dithiobis(2-nitrobenzoate)
-
-
aminooxyacetic acid

-
-
aminooxyacetic acid
-
chronical treatment of rats with CGL inhibitor (DL)-propargylglycine or cystathionine beta-synthase inhibitor aminooxyacetic acid or a combination of both. Only the rats with combination therapy show a decrease in urinary sulfate excretion rate, which is associated with an increase in mean arterial pressure. Urine flow and sodium excretion are also increased in combination group as consequent to the increase in mean arterial pressure. Glomerular filtration rate does not alter due to these treatments, renal blood flow is lowered only in the combination group compared to the control group
beta,beta,beta-trifluoroalanine

-
the epsilon-NH2 group of the active-site Lys forms a Schiff base with pyridoxal 5'phosphate is capable of interacting with the beta carbon of the suicide inactivator beta,beta,beta-trifluoroalanine
beta,beta,beta-trifluoroalanine
-
-
beta,beta,beta-trifluoroalanine
-
irreversible
Beta-cyano-L-alanine

-
-
Beta-cyano-L-alanine
-
pretreating adiopose tissues with the CSE inhibitor beta-cyano-L-alanine (BCA) (2 mmol/l) for 20 min significantly decreased the endogenous H2S production by 89%, as compared with controls
Beta-cyano-L-alanine
-
10 mM inhibits testosterone induced H2S biosynthesis
Beta-cyanoalanine

-
-
Beta-cyanoalanine
-
reversible inhibitor of CSE
cycloserine

-
DL-cycloserine
cycloserine
-
partially competitive
cycloserine
-
D-cycloserine
Cys

-
-
Cys
-
the regulatory site of the enzyme is specific for L-Cys
Cys
-
above 10 mM, inhibits replacement reaction with L-homoserine and L-Cys
DL-propargylglycine

-
-
DL-propargylglycine
-
irreversible inhibitor of CSE
DL-propargylglycine
-
irreversible inhibitor
DL-propargylglycine
an irreversible enzyme inhibitor, molecular mechanism of DL-propargylglycine action in vivo
DL-propargylglycine
-
2% residual activity at 5 mM
DL-propargylglycine
-
elevates blood pressure
DL-propargylglycine
-
irreversible inhibitor of CSE
DL-propargylglycine
-
pretreating adiopose tissues with the CSE inhibitor DL-propargylglycine (PPG) (10 mmol/l) for 20 min significantly decreased the endogenous H2S production by 85%, as compared with controls
DL-propargylglycine
-
irreversible inhibitor of CSE
DL-propargylglycine
-
irreversible inhibitor of CSE
DL-propargylglycine
-
selective inhibitor of cystathionine gamma-lyase
Hg2+

-
strong
Hg2+
-
HgCl2, alpha,beta-elimination L-homoserine
hydroxylamine

-
-
hydroxylamine
-
alpha,beta-elimination of L-homoserine
L-cysteine

-
0.4 mM, 6% residual activity
L-cysteine
-
substrate inhibition mainly due to removal of cofactor
L-cysteine
-
inhibits alpha,gamma elimination activity
N-ethylmaleimide

-
81% residual activity at 5 mM
NaCl

-
5% w/v
NaCl
-
59% residual activity at 5 mM
PCMB

-
0.05 mM, inhibition is partly relieved by 0.2 mM 2,3-dimercaptopropanol
PCMB
-
alpha,beta-elimination L-homoserine
Penicillamine

-
D-penicillamine; L-penicillamine
Penicillamine
-
D-penicillamine; L-penicillamine
Penicillamine
-
alpha,beta-elimination of L-homoserine; D-penicillamine; L-penicillamine
phenylhydrazine

-
2.8% residual activity at 5 mM
phenylhydrazine
-
alpha,beta-elimination L-homoserine as substrate
propargylglycine

-
-
propargylglycine
-
10 mM inhibits testosterone induced H2S biosynthesis
propargylglycine
-
alpha,beta-elimination L-homoserine
Semicarbazide

-
-
Semicarbazide
-
11% residual activity at 5 mM
Semicarbazide
-
alpha,beta-elimination L-homoserine as substrate
trifluoro-Ala

-
-
trifluoro-Ala
-
trifluoro-D,L-Ala
Zn2+

-
0.1 mM, weak
Zn2+
-
ZnCl2, alpha,beta-elimination L-homoserine
additional information

-
no or poor inhibition by methylselenocysteine, D-cycloserine, pargyline, and parsalmide
-
additional information
-
no inhibition by 4-hydroxybutyrate
-
additional information
-
not inhibitory: EDTA
-
additional information
-
the reaction of cystathionase with cystathionine and homoserine decreases rapidly with time. The reaction becomes inhibited, probably by the formation of a stable enzyme-bound intermediate. The inhibition can be partially relieved by pyridoxal 5'-phosphate, NaCl, alpha-keto acids, and other compounds. These agents prevent the inhibition by providing an environment that helps to decrease the nucleophilicity of the sulfhydryl
-
additional information
-
inhibitory effect of the chelating agents and related compounds is at least partly and in some instances completely eliminated in the presence of an increased concentration of pyridoxal 5'-phosphate
-
additional information
-
administration of CSE inhibitors enhances the glucose uptake of adipocytes
-
additional information
-
dexamethasone reduces the expression of cystathionine gamma lyase. Also reduces LPS-induced upregulation of CSE in fetal liver cells. 6-amino-4-(4-phenoxyphenylethylamino) quinazoline (QNZ) 10 nM, a selective inhibitor of transcription via the NF-kappaB pathway, abolishs lipopolysaccharide-induced upregulation of CSE expression
-
additional information
-
extent to which inactivation occurs with the various mercury-containing compounds in descending order: Cys-S-Hg-S-Cys, HgCl2, CH3Hg-S-Cys
-
additional information
cystathionine gamma-lyase encoded by CYS3 is repressed by addition of cysteine to the growth medium
-
additional information
-
cystathionine gamma-lyase encoded by CYS3 is repressed by addition of cysteine to the growth medium
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.153 - 1.417
(DL)-homocysteine
28.41
3-chloro-DL-alanine
-
pH 8.0, 37°C
2.39
beta-chloro-L-Ala
-
-
0.1 - 3.2
beta-chloro-L-alanine
0.51 - 1.5
djenkolic acid
3.27 - 3.4
DL-cystathionine
0.204 - 25.5
L-cystathionine
0.7 - 5.3
O-acetyl-L-serine
2.75
S-(2-aminoethyl)-L-cysteine
-
pH 8.0, 37°C
13.13
S-methyl-L-cysteine
-
pH 8.0, 37°C
additional information
additional information
-
1.153
(DL)-homocysteine

-
pH 8.0, 37°C
1.417
(DL)-homocysteine
-
pH 8.0, 37°C
0.1
beta-chloro-L-alanine

-
Y123F/Y124F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
0.17
beta-chloro-L-alanine
-
Y123F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
1.21
beta-chloro-L-alanine
-
wild type, 20 mM potassium phosphate buffer, pH 7.4, 25°C
3.2
beta-chloro-L-alanine
-
Y124F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
0.76
D-alanine

-
racemization, Y123F/Y124F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
10
D-alanine
-
racemization, wild type, 20 mM potassium phosphate buffer, pH 7.4, 25°C
22.4
D-alanine
-
racemization, Y123F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
25.3
D-alanine
-
racemization, Y124F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
0.51
djenkolic acid

wild-type, pH 9.0, 40°C
0.86
djenkolic acid
mutant N360S, pH 9.0, 40°C
1.5
djenkolic acid
mutant S77A, pH 9.0, 40°C
3.27
DL-cystathionine

-
pH 8.0, 37°C
3.36
DL-cystathionine
-
native enzyme, pH not specified in the publication, temperature not specified in the publication
3.4
DL-cystathionine
-
protein bound to polyethylene glycol, pH not specified in the publication, temperature not specified in the publication
1
L-alanine

-
racemization, Y123F/Y124F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
10
L-alanine
-
racemization, wild type, 20 mM potassium phosphate buffer, pH 7.4, 25°C
14.3
L-alanine
-
racemization, Y123F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
20
L-alanine
-
racemization, Y124F mutant, 20 mM potassium phosphate buffer, pH 7.4, 25°C
0.029
L-Cys

-
pH 8.0, 37°C
0.069
L-Cys
-
pH 8.0, 37°C
0.204
L-cystathionine

-
-
0.232
L-cystathionine
-
pH 8.0, 37°C
0.236
L-cystathionine
-
pH 8.0, 37°C
0.4
L-cystathionine
for variant S403
0.42
L-cystathionine
-
His-tagged recombinant wild type enzyme, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.45
L-cystathionine
-
native wild type enzyme, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.6
L-cystathionine
for mutant T67I
0.6
L-cystathionine
for variant I403
0.71
L-cystathionine
-
pH 7.2, 25°C, recombinant wild-type enzyme
0.72
L-cystathionine
for mutant Q240E
0.76
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48A
0.81
L-cystathionine
-
mutant enzyme E48F, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.82
L-cystathionine
-
mutant enzyme E48A, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.87
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48D
0.9
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48Q
0.9
L-cystathionine
wild-type, pH 9.0, 40°C
1.11
L-cystathionine
-
mutant enzyme E48D, in 50 mM potassium phosphate, pH 7.8, at 25°C
2.4
L-cystathionine
mutant S77A, pH 9.0, 40°C
5.2
L-cystathionine
-
mutant enzyme E333A, in 50 mM potassium phosphate, pH 7.8, at 25°C
6.1
L-cystathionine
mutant N360S, pH 9.0, 40°C
8.7
L-cystathionine
-
pH 7.6, 37°C
10.6
L-cystathionine
-
pH 7.6, 37°C
11.1
L-cystathionine
-
pH 7.6, 37°C
11.2
L-cystathionine
-
pH 7.6, 37°C
11.8
L-cystathionine
-
pH 7.6, 37°C
12
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333A
12
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333D
13
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333Q
25.5
L-cystathionine
-
pH 7.6, 37°C
0.09
L-cysteine

-
pH 7.2, 25°C, recombinant wild-type enzyme
0.11
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48A
0.18
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48Q
0.21
L-cysteine
wild-type, pH 9.0, 40°C
0.4
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48D
0.4
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
0.4
L-cysteine
mutant N360S, pH 9.0, 40°C
0.5
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48A/E333A
0.5
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.62
L-cysteine
-
pH 8.0, 37°C
0.68
L-cysteine
-
pH 7.6, 37°C
0.7
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.75
L-cysteine
-
pH 7.6, 37°C
0.76
L-cysteine
-
mutant enzyme E339Y, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.88
L-cysteine
-
pH 7.6, 37°C
1.08
L-cysteine
-
pH 7.6, 37°C
1.16
L-cysteine
-
pH 7.6, 37°C
1.2
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333A
1.8
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333D
1.9
L-cysteine
-
wild type enzyme, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
2.46
L-cysteine
-
pH 7.6, 37°C
3.3
L-cysteine
-
mutant enzyme E339K, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
3.4
L-cysteine
for variant I403
3.5
L-cysteine
for variant S403
4.1
L-cysteine
for mutant T67I
7.7
L-cysteine
-
mutant enzyme E339A, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.032
L-cystine

-
-
1.29
L-cystine
-
pH 8.0, 37°C
5.4
L-homocysteine

for variant S403
7
L-homocysteine
for variant I403
8
L-homocysteine
for mutant T67I
0.7
O-acetyl-L-serine

-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.9
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333D
1.4
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48D
1.5
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48A
1.5
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
2.2
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333A
2.5
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant wild-type enzyme
2.9
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48A/E333A
4.4
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48Q
5.3
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333Q
additional information
additional information

-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
Michaelis-Menten kinetics
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.19 - 0.24
djenkolic acid
0.11 - 0.13
DL-cystathionine
0.02 - 7.5
L-cystathionine
0.82 - 3.7
L-homocysteine
0.0035 - 0.0142
O-acetyl-L-serine
0.19
djenkolic acid

mutant N360S, pH 9.0, 40°C
0.22
djenkolic acid
mutant S77A, pH 9.0, 40°C
0.24
djenkolic acid
wild-type, pH 9.0, 40°C
0.11
DL-cystathionine

-
protein bound to polyethylene glycol, pH not specified in the publication, temperature not specified in the publication
0.13
DL-cystathionine
-
native enzyme, pH not specified in the publication, temperature not specified in the publication
0.02
L-cystathionine

for mutante Q240E
0.24
L-cystathionine
mutant N360S, pH 9.0, 40°C
0.39
L-cystathionine
-
mutant enzyme E48F, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.45
L-cystathionine
for mutante T67I
0.48
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.54
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48A
0.67
L-cystathionine
-
mutant enzyme E48A, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.69
L-cystathionine
-
mutant enzyme E333A, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.7
L-cystathionine
mutant S77A, pH 9.0, 40°C
0.76
L-cystathionine
-
mutant enzyme E48D, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.78
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333A
0.9
L-cystathionine
-
native wild type enzyme, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.98
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333D
1.29
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48Q
1.4
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48D
1.51
L-cystathionine
-
pH 7.2, 25°C, recombinant wild-type enzyme
1.7
L-cystathionine
for variante S403
1.81
L-cystathionine
-
His-tagged recombinant wild type enzyme, in 50 mM potassium phosphate, pH 7.8, at 25°C
1.9
L-cystathionine
for variante I403
2
L-cystathionine
wild-type, pH 9.0, 40°C
0.007
L-cysteine

mutant N360S, pH 9.0, 40°C
0.009
L-cysteine
wild-type, pH 9.0, 40°C
0.029
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.09
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48A
0.11
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48A/E333A
0.12
L-cysteine
-
wild type enzyme, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.15
L-cysteine
-
pH 7.2, 25°C, recombinant wild-type enzyme
0.16
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
0.18
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48Q
0.24
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333D
0.3
L-cysteine
for mutante T67I
0.32
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48D
0.34
L-cysteine
-
mutant enzyme E339K, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.5
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.67
L-cysteine
for variante I403
0.67
L-cysteine
for variante S403
0.76
L-cysteine
-
mutant enzyme E339Y, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
1.3
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333A
1.44
L-cysteine
-
mutant enzyme E339A, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.82
L-homocysteine

for mutante T67I
3.5
L-homocysteine
for variante S403
3.7
L-homocysteine
for variante I403
0.0035
O-acetyl-L-serine

-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.0045
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333D
0.0047
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48A/E333A
0.0053
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48D
0.0058
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333A
0.0092
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
0.0097
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant wild-type enzyme
0.0102
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.0124
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48Q
0.0142
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48A
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.15 - 0.47
djenkolic acid
0.029 - 0.04
DL-cystathionine
0.0037 - 4.3
L-cystathionine
0.0016 - 0.01
O-acetyl-L-serine
0.15
djenkolic acid

mutant S77A, pH 9.0, 40°C
0.22
djenkolic acid
mutant N360S, pH 9.0, 40°C
0.47
djenkolic acid
wild-type, pH 9.0, 40°C
0.029
DL-cystathionine

-
protein bound to polyethylene glycol, pH not specified in the publication, temperature not specified in the publication
0.04
DL-cystathionine
-
native enzyme, pH not specified in the publication, temperature not specified in the publication
0.0037
L-cystathionine

-
pH 7.2, 25°C, recombinant mutant E48A/E333A
0.0088
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.0169
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
0.036
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.039
L-cystathionine
mutant N360S, pH 9.0, 40°C
0.065
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333A
0.082
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E333D
0.132
L-cystathionine
-
mutant enzyme E333A, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.147
L-cystathionine
-
mutant enzyme E333Y, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.29
L-cystathionine
mutant S77A, pH 9.0, 40°C
0.49
L-cystathionine
-
mutant enzyme E48F, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.68
L-cystathionine
-
mutant enzyme E48D, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.71
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48A
0.82
L-cystathionine
-
mutant enzyme E48A, in 50 mM potassium phosphate, pH 7.8, at 25°C
1.4
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48Q
1.59
L-cystathionine
-
pH 7.2, 25°C, recombinant mutant E48D
1.98
L-cystathionine
-
native wild type enzyme, in 50 mM potassium phosphate, pH 7.8, at 25°C
2.1
L-cystathionine
-
pH 7.2, 25°C, recombinant wild-type enzyme
2.2
L-cystathionine
wild-type, pH 9.0, 40°C
4.3
L-cystathionine
-
His-tagged recombinant wild type enzyme, in 50 mM potassium phosphate, pH 7.8, at 25°C
0.018
L-cysteine

mutant N360S, pH 9.0, 40°C
0.043
L-cysteine
wild-type, pH 9.0, 40°C
0.06
L-cysteine
-
wild type enzyme, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.06
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.11
L-cysteine
-
mutant enzyme E339K, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.13
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333D
0.19
L-cysteine
-
mutant enzyme E339A, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.21
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48A/E333A
0.31
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
0.43
L-cysteine
-
mutant enzyme E339Y, in 50 mM sodium phosphate buffer (pH 8.2) , at 37°C
0.49
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.72
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48D
0.8
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48A
0.81
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E333A
1.02
L-cysteine
-
pH 7.2, 25°C, recombinant mutant E48Q
1.7
L-cysteine
-
pH 7.2, 25°C, recombinant wild-type enzyme
0.0016
O-acetyl-L-serine

-
pH 7.2, 25°C, recombinant mutant E48A/E333A
0.0019
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333Q
0.0026
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333A
0.0028
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48Q
0.0038
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant wild-type enzyme and mutant E48D
0.005
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E333D
0.005
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48D/E333D
0.006
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48Q/E333Q
0.01
O-acetyl-L-serine
-
pH 7.2, 25°C, recombinant mutant E48A
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.