Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli XL-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R197C | the mutant shows about 44% activity compared to the wild type enzyme | Homo sapiens |
R62H | exchange of Arg62 for His62 shifts the geometry of the active site, decreases the strength of pyridoxal 5'-phosphate binding, and makes this bond pH dependent under physiological conditions | Homo sapiens |
T311I | the mutant shows wild type activity | Homo sapiens |
T67I | the mutant shows about 13% activity compared to the wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-propargylglycine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P32929 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cystathionine + H2O | - |
Homo sapiens | L-cysteine + 2-oxobutanoate + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CTH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | severe loss of cystathionine gamma-lyase activity is accompanied by adverse clinical effects | Homo sapiens |