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Information on EC 3.1.1.78 - polyneuridine-aldehyde esterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.78 polyneuridine-aldehyde esterase
IUBMB Comments
Following hydrolysis of this indole alkaloid ester the carboxylic acid decarboxylates spontaneously giving the sarpagan skeleton. The enzyme also acts on akuammidine aldehyde (the 16-epimer of polyneuridine aldehyde).
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Word Map
  • 3.1.1.78
  • cruzi
  • chagas
  • epimastigotes
  • trypomastigotes
  • l-like
  • trypanocidal
  • anti-cruzipain
  • papain-like
The expected taxonomic range for this enzyme is: Rauvolfia serpentina
Synonyms
polyneuridine aldehyde esterase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
polyneuridine aldehyde + H2O = 16-epivellosimine + CO2 + methanol
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