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Literature summary for 3.1.1.78 extracted from
- Characterization of polyneuridine aldehyde esterase, a key enzyme in the biosynthesis of sarpagine/ajmaline-type alkaloids (1983), Planta Med., 48, 221-227.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-dithiodipyridine | - |
Rauvolfia serpentina Benth. ex Kurz |  |
| 5,5'-dithio-bis-(2-nitrobenzoate) | - |
Rauvolfia serpentina Benth. ex Kurz | |
| iodoacetamide | 100% inhibition at 5 mM | Rauvolfia serpentina Benth. ex Kurz | |
| MgCl2 | 50% inhibition at 0.25 mM | Rauvolfia serpentina Benth. ex Kurz | |
| MnCl2 | 50% inhibition at 0.25 mM | Rauvolfia serpentina Benth. ex Kurz | |
| ZnCl2 | 50% inhibition at 0.25 mM | Rauvolfia serpentina Benth. ex Kurz | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.25 | - |
polyneuridine aldehyde | - |
Rauvolfia serpentina Benth. ex Kurz | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polyneuridine aldehyde + H2O | Rauvolfia serpentina Benth. ex Kurz | key enzyme in the biosynthesis of sarpagine/ajmaline type alkaloids | 16-epivellosimine + CO2 + methanol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rauvolfia serpentina Benth. ex Kurz | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rauvolfia serpentina Benth. ex Kurz |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, 5 months, 0.2 M 2-mercaptoethanol, 100% activity | Rauvolfia serpentina Benth. ex Kurz |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| akuammidine aldehyde + H2O | - |
Rauvolfia serpentina Benth. ex Kurz | vellosiminol + CO2 + methanol | - |
? | |
| polyneuridine aldehyde + H2O | - |
Rauvolfia serpentina Benth. ex Kurz | 16-epivellosimine + CO2 + methanol | - |
? | |
| polyneuridine aldehyde + H2O | key enzyme in the biosynthesis of sarpagine/ajmaline type alkaloids | Rauvolfia serpentina Benth. ex Kurz | 16-epivellosimine + CO2 + methanol | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Rauvolfia serpentina Benth. ex Kurz |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 8.5 | - |
Rauvolfia serpentina Benth. ex Kurz |
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