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Synonyms
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adenylate-nucleoside phosphotransferase
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adenylic acid:deoxythymidine 5'-phosphotransferase
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AMP:deoxythymidine 5'-phosphotransferase
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AMP:deoxythymidine kinase
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thymidine phosphotransferase
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AMP + thymidine = adenosine + dTMP
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phospho group transfer
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AMP:thymidine 5'-phosphotransferase
The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP kinase).
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AMP + 5-bromodeoxyuridine
adenosine + 5-bromodeoxyuridine 5'-phosphate
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Substrates: -
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AMP + adenosine
adenosine + AMP
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Substrates: -
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AMP + cytidine
adenosine + cytidine 5'-phosphate
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Substrates: -
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AMP + deoxyuridine
adenosine + deoxyuridine 5'-phosphate
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Substrates: -
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AMP + guanosine
adenosine + guanosine 5'-phosphate
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Substrates: -
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AMP + thymidine
adenosine + dTMP
AMP + uridine
adenosine + uridine 5'-phosphate
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Substrates: -
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AMP + thymidine
adenosine + dTMP
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Substrates: AMP can be substituted by GMP, dAMP, CMP, UMP, dUMP, dTMP
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AMP + thymidine
adenosine + dTMP
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Substrates: -
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AMP + thymidine
adenosine + dTMP
Epidendrum hybrid
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Substrates: -
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AMP + thymidine
adenosine + dTMP
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Substrates: -
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AMP + thymidine
adenosine + dTMP
Herpes simplex virus
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Substrates: -
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AMP + thymidine
adenosine + dTMP
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Substrates: -
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AMP + thymidine
adenosine + dTMP
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Substrates: -
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AMP + thymidine
adenosine + dTMP
AMP + thymidine
adenosine + dTMP
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Substrates: -
?
AMP + thymidine
adenosine + dTMP
Epidendrum hybrid
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Substrates: -
?
AMP + thymidine
adenosine + dTMP
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Substrates: -
?
AMP + thymidine
adenosine + dTMP
Herpes simplex virus
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Substrates: -
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AMP + thymidine
adenosine + dTMP
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Substrates: -
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AMP + thymidine
adenosine + dTMP
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Substrates: -
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9-beta-D-Arabinofuranosyladenine 5'-monophosphate
Herpes simplex virus
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1.28
adenosine
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38°C, pH 7.5
4.71
uridine
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38°C, pH 7.5
0.0023
AMP
Herpes simplex virus
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37°C, pH 7.8
0.0021
thymidine
Herpes simplex virus
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37°C, pH 7.8
0.84 - 0.88
thymidine
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38°C, pH 7.5
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0.47
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young and expanded leaf
42.2
Herpes simplex virus
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0.05
Epidendrum hybrid
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leaf
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7.6
Herpes simplex virus
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6.3 - 8.8
Herpes simplex virus
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17% of maximal activity at pH 6.3, 32% of maximal activity at pH 8.8
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37 - 38
Herpes simplex virus
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bird's nest fern
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brenda
Epidendrum hybrid
crucifix orchid
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brenda
Jerusalem artichoke
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brenda
barley
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brenda
lucerne
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brenda
Herpes simplex virus
hamster BHK cells infected with virus
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brenda
Herpes simplex virus
type 1
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brenda
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brenda
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brenda
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brenda
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brenda
Epidendrum hybrid
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brenda
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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90600 - 111000
Herpes simplex virus
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glycerol density gradient centrifugation
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37
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60 min, 95% loss of activity
63
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5 min, complete inactivation
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bovine serum albumin stabilizes
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not stabilized by AMP or thymidine
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0°C, 6 months, 20% loss of activity
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type 1, hamster BHK-cells infected with virus
Herpes simplex virus
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Falke, D.; Nehrbass, W.; Brauer, D.; Mller, W.E.G.
Adenylic acid: deoxythymidine 5-phosphotransferase: evidence for the existence of a novel Herpes simplex virus-induced enzyme
J. Gen. Virol.
53
247-255
1981
Herpes simplex virus
brenda
Grivell, A.R.; Jackson, J.F.
Thymidine phosphotransferase and nucleotide phosphohydrolase of the fern Asplenium nidus. General properties and inhibition by adenosine 3:5-cyclic monophosphate
Biochem. J.
155
571-581
1976
Asplenium nidus, Epidendrum hybrid, Helianthus tuberosus, Hordeum vulgare, Medicago sativa
brenda
Labenz, J.; Mller, W.E.G.; Falke, D.
Inhibition of the Herpes simplex virus-coded thymidine kinase-complex by 9-beta-D-arabinofuranosyladenine 5-monophosphate (ara-AMP) and 9-(2-hydroxyethoxymethyl)guanine-monophosphate (acyclo-GMP)
Arch. Virol.
81
205-212
1984
Herpes simplex virus
brenda
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