Ligand thymidine

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Basic Ligand Information

Molecular Structure
Picture of thymidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H14N2O5
thymidine
IQFYYKKMVGJFEH-XLPZGREQSA-N
Synonyms:
1-(2''-deoxy-beta-D-threo-pentafuranosyl)thymine, 5-methyldeoxyuridine, D-deoxythymidine, D-thymidine, deoxythymidine

Show all pahtways known for Show all pathways known for thymidine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thymidine + 2 O2 + H2O = 1-(2-deoxyriburonosyl)thymine + 2 H2O2
show the reaction diagram
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thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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AMP + thymidine = adenosine + dTMP
show the reaction diagram
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ADP + thymidine = AMP + dTMP
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thymine + 2-deoxy-D-ribose 1-phosphate = thymidine + phosphate
show the reaction diagram
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dTMP + H2O = thymidine + phosphate
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5'-dTMP + H2O = deoxythymidine + phosphate
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Substrate in Enzyme-catalyzed Reactions (280 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thymidine + O2 = 1-riburonosylthymine + H2O
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thymidine + 2 O2 + H2O = 1-(2-deoxyriburonosyl)thymine + 2 H2O2
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AMP + thymidine = adenosine + dTMP
show the reaction diagram
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ADP + thymidine = AMP + dTMP
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ATP + thymidine = ADP + thymidine 5'-phosphate
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thymidine + H2O = D-ribose + thymine
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thymidine + alpha-naphthylphosphate + H2O = thymidine 3'-alpha-naphthol + phosphate
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Product in Enzyme-catalyzed Reactions (51 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + thymine = thymidine + uracil
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3'-TMP + thymidine = thymidine + TMP
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3'-O-acetylthymidine + H2O = thymidine + acetate
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5'-TMP + H2O = thymidine + phosphate
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thymidine 3'-monophosphate + H2O = thymidine + phosphate
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5'-dTMP + H2O = thymidine + phosphate
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3'-dTMP + H2O = deoxythymidine + phosphate
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TpT + H2O + H2O = 5'-TMP + thymidine
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thymidine p-nitrophenyl phosphate + H2O = thymidine + p-nitrophenyl phosphate
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deoxythymidine-5'-p-nitrophenyl phosphate + H2O = deoxythymidine + 4-nitrophenol
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dTTP + H2O = deoxythymidine + triphosphate
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thymidine 5'-p-nitrophenylphosphate + H2O = thymidine + 4-nitrophenyl phosphate
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thymidine 5'-alpha-naphthylphosphate + H2O = thymidine + alpha-naphthylphosphate
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T(6-4)C photoproduct (in DNA) = 2 thymidine + cytosine (in DNA)
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (87 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
8% inhibition of fructose 6-phosphate reduction
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complete inhibition of enzyme form GSII, partial inhibition of enzyme form GSI, no effect on enzyme form GSIII
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3D Structure of Enzyme-Ligand-Complex (PDB) (38 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (72 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.41
-
pH and temperature not specified in the publication

KM Value (179 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
-
0.09
-
-
0.004
-
;

Ki Value (15 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.45
-
25°C, pH 6.5

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for thymidine

ChEBI
PubChem
ChEBI
PubChem