Ligand dTMP

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Basic Ligand Information

Molecular Structure
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Molecular Formula
BRENDA Name
InChIKey
C10H15N2O8P
dTMP
GYOZYWVXFNDGLU-XLPZGREQSA-N
Synonyms:
2'-deoxythymidine 5'-phosphate, 5'-deoxy TMP, 5'-dTMP, 5'-thymidine monophosphate, 5'-TMP, 5-methyl-2'-deoxyuridylate, 5-methyl-dUMP, D-dTMP, deoxythymidine 5'-phosphate, deoxythymidine 5-phosphate, deoxythymidine monophosphate, Deoxythymidylic acid, ribothymidylic acid, thymidine-5'-phosphate, thymidine 5'-monophosphate, thymidine 5'-phosphate, thymidine 5-monophosphate, thymidine monophosphate, thymidine phosphate, thymidylate, TMP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (130 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + dTMP = ADP + dTDP
show the reaction diagram
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ATP + TMP = ADP + TDP
show the reaction diagram
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dTMP + H2O = thymidine + phosphate
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5'-dTMP + H2O = deoxythymidine + phosphate
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In Vivo Product in Enzyme-catalyzed Reactions (71 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
AMP + thymidine = adenosine + dTMP
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ADP + thymidine = AMP + dTMP
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5-methyl-dCMP + H2O = dTMP + NH3
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TDP + H2O = TMP + phosphate
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TTP + 2 H2O = TMP + 2 phosphate
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Substrate in Enzyme-catalyzed Reactions (462 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thymidylate + 2-oxoglutarate + O2 = 5-methyluridine 5'-phosphate + succinate + CO2
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dTMP + base = dNMP + thymine
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5'-dTMP + thymidine = 5'-deoxythymidine + TMP
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ATP + dTMP = ADP + dTDP
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ATP + TMP = ADP + TDP
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ATP + TMP = ADP + TDP
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ATP + dTMP = ADP + dTDP
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TMP + [phosphate]n = TDP + [phosphate]n-1
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5'-TMP + H2O = thymidine + phosphate
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dTMp + H2O = dT + phosphate
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dTMP + H2O = deoxythymidine + phosphate
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5'-dTMP + H2O = thymidine + phosphate
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5'-deoxy TMP + H2O = thymine + deoxyribose 5-phosphate
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Product in Enzyme-catalyzed Reactions (216 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
AMP + thymidine = adenosine + dTMP
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ADP + thymidine = AMP + dTMP
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TDP + D-glucose = TMP + D-glucose 6-phosphate
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TDP + H2O = TMP + phosphate
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oligonucleotides + H2O = dCMP + dTMP
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dTTP + H2O = dTMP + diphosphate
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TDP + H2O = TMP + phosphate
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dTTP + H2O = dTMP + diphosphate
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thymidine 5'-p-nitrophenylphosphate + H2O = p-nitrophenol + TMP
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dTTP + H2O = dTMP + diphosphate
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dTTP + H2O = dTMP + diphosphate
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dTTP + acetate + citrate (pro-3S)-lyase = dTMP + diphosphate + citrate(pro-3S)-lyase
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TTP + o-succinylbenzoate + CoA = TMP + diphosphate + o-succinylbenzoyl-CoA
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TTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = TMP + diphosphate + (deoxyribonucleotide)n+m
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of hydrolysis of 3'-dTMP
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Inhibitor in Enzyme-catalyzed Reactions (83 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
25% inhibition at 0.6 mM
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5 mM, 42% inhibition
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less effective than AMP
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weak inhibition
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dGMP or 5-hydroxymethyl-dCMP as substrate
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inhibits uridylyl removing activity
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1.1 mM: 12% inhibition
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0.400 mM 50% inhibition
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0.2 mM, 33% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (59 results)