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Information on EC 2.3.1.282 - phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase

for references in articles please use BRENDA:EC2.3.1.282
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IUBMB Comments
The enzyme, present in certain pathogenic species of mycobacteria, catalyses the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters. The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, which loads them onto EC 2.3.1.111, mycocerosate synthase. That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
2
a mycocerosyl-[mycocerosic acid synthase]
+
a phthiocerol
=
a dimycocerosyl phthiocerol
+
2
holo-[mycocerosic acid synthase]
2
a mycocerosyl-[mycocerosic acid synthase]
+
a phthiodiolone
=
a dimycocerosyl phthiodiolone
+
2
holo-[mycocerosic acid synthase]
2
a mycocerosyl-[mycocerosic acid synthase]
+
a phenolphthiocerol
=
a dimycocerosyl phenolphthiocerol
+
2
holo-[mycocerosic acid synthase]
Synonyms
papA5, polyketide-associated protein A5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
show the reaction diagram
(3)
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-
-
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol = a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
show the reaction diagram
(1)
-
-
-
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone = a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
show the reaction diagram
(2)
-
-
-
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