Application | Comment | Organism |
---|---|---|
synthesis | use of PapA5 and a mutant mycocerosic acid synthase for synthesis of nonmethylated variants of mycocerosate esters | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
homology modeling and docking of modeled mycocerosic acid synthase docked on the structure of PapA5 | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.024 | - |
2-Dodecanol | pH 7.0, 30°C | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol | Mycobacterium tuberculosis | - |
a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol | Mycobacterium tuberculosis H37Rv | - |
a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol | Mycobacterium tuberculosis | - |
a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol | Mycobacterium tuberculosis H37Rv | - |
a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone | Mycobacterium tuberculosis | - |
a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone | Mycobacterium tuberculosis H37Rv | - |
a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase] | - |
? | |
additional information | Mycobacterium tuberculosis | PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate | ? | - |
? | |
additional information | Mycobacterium tuberculosis H37Rv | PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WIN5 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WIN5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol | - |
Mycobacterium tuberculosis | a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol | - |
Mycobacterium tuberculosis H37Rv | a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol | - |
Mycobacterium tuberculosis | a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol | - |
Mycobacterium tuberculosis H37Rv | a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone | - |
Mycobacterium tuberculosis | a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase] | - |
? | |
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone | - |
Mycobacterium tuberculosis H37Rv | a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase] | - |
? | |
lauroyl-[mycocerosic acid synthase] + 2-dodecanol | - |
Mycobacterium tuberculosis | 2-dodecanyl dodecanoate + holo-[mycocerosic acid synthase] | - |
? | |
lauroyl-[mycocerosic acid synthase] + 2-dodecanol | - |
Mycobacterium tuberculosis H37Rv | 2-dodecanyl dodecanoate + holo-[mycocerosic acid synthase] | - |
? | |
additional information | PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate | Mycobacterium tuberculosis | ? | - |
? | |
additional information | PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate | Mycobacterium tuberculosis H37Rv | ? | - |
? |