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Literature summary for 2.3.1.282 extracted from

  • Trivedi, O.A.; Arora, P.; Vats, A.; Ansari, M.Z.; Tickoo, R.; Sridharan, V.; Mohanty, D.; Gokhale, R.S.
    Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid (2005), Mol. Cell, 17, 631-643 .
    View publication on PubMed

Application

Application Comment Organism
synthesis use of PapA5 and a mutant mycocerosic acid synthase for synthesis of nonmethylated variants of mycocerosate esters Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
homology modeling and docking of modeled mycocerosic acid synthase docked on the structure of PapA5 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
2-Dodecanol pH 7.0, 30°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol Mycobacterium tuberculosis
-
a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol Mycobacterium tuberculosis H37Rv
-
a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol Mycobacterium tuberculosis
-
a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol Mycobacterium tuberculosis H37Rv
-
a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone Mycobacterium tuberculosis
-
a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone Mycobacterium tuberculosis H37Rv
-
a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
?
additional information Mycobacterium tuberculosis PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate ?
-
?
additional information Mycobacterium tuberculosis H37Rv PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate ?
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WIN5
-
-
Mycobacterium tuberculosis H37Rv P9WIN5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol
-
Mycobacterium tuberculosis a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol
-
Mycobacterium tuberculosis H37Rv a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol
-
Mycobacterium tuberculosis a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol
-
Mycobacterium tuberculosis H37Rv a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone
-
Mycobacterium tuberculosis a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
?
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone
-
Mycobacterium tuberculosis H37Rv a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
?
lauroyl-[mycocerosic acid synthase] + 2-dodecanol
-
Mycobacterium tuberculosis 2-dodecanyl dodecanoate + holo-[mycocerosic acid synthase]
-
?
lauroyl-[mycocerosic acid synthase] + 2-dodecanol
-
Mycobacterium tuberculosis H37Rv 2-dodecanyl dodecanoate + holo-[mycocerosic acid synthase]
-
?
additional information PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate Mycobacterium tuberculosis ?
-
?
additional information PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate Mycobacterium tuberculosis H37Rv ?
-
?