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Information on EC 2.1.1.9 - thiol S-methyltransferase
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EC Tree
2.1.1.9 thiol S-methyltransferaseIUBMB Comments
H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.
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Word Map
- 2.1.1.9
-
trail
- trimethyltin
- hippocampal
-
neuropsychological
- deficit
-
verbal
-
isobaric
-
neurotoxic
-
stroop
-
fluency
-
predator
-
anxiety
-
odor
-
fear
-
neurotoxicant
- organotins
- gyrus
-
wisconsin
-
trimodality
-
terror
-
cystectomy
-
norm
-
card
-
mini-mental
-
limbic
-
semantic
-
tympanic
-
naturalistic
-
community-dwelling
-
muscle-invasive
-
salience
-
set-shifting
-
psychometric
-
wechsler
-
subtests
-
arthrodesis
-
orbitrap
-
metatarsal
-
montreal
-
visuomotor
- medicine
-
dentata
- hallux
- valgus
-
self-esteem
-
visuospatial
-
ammon
-
dual-task
-
phonemic
-
tag-based
-
perseverative
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
tmt, thiol methyltransferase, s-methyltransferase, ppsabath1, s-methyltransferase 1, thiol s-methyltransferase, sabath methyltransferase, hmt/htmt, athol1, oshol1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Met S-methyltransferase
methionine S-methyltransferase
methyltransferase, thiol
-
-
-
-
MMT
S-adenosyl-L-methionine-dependent halide/thiol methyltransferase
S-adenosylmethionine-dependent halide/thiol methyltransferase
S-methyltransferase
-
-
-
-
thiol methyltransferase
-
-
-
-
TMT
S-adenosyl-L-methionine-dependent halide/thiol methyltransferase
-
S-adenosyl-L-methionine-dependent halide/thiol methyltransferase
-
-
S-adenosylmethionine-dependent halide/thiol methyltransferase
bifunctional enzyme
TMT
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether
-
-
-
-
S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether
mechanism
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
S-methylation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
,
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:thiol S-methyltransferase
H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.
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CAS REGISTRY NUMBER
COMMENTARY
9029-81-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2Z)-[(4R)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-sulfanylpiperidin-3-ylidene]acetic acid + S-adenosyl-L-methionine
(2Z)-[(4R)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-(methylsulfanyl)piperidin-3-ylidene]acetic acid + S-adenosyl-L-homocysteine
-
thiol metabolite H4 of prodrug clopidogrel. The intrinsic clearance value for the S-methylation of metabolite H3 in microsomes is 98.1fold higher than that for H4
-
-
?
(2Z)-[(4S)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-sulfanylpiperidin-3-ylidene]acetic acid + S-adenosyl-L-methionine
(2Z)-[(4S)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-(methylsulfanyl)piperidin-3-ylidene]acetic acid + S-adenosyl-L-homocysteine
-
thiol metabolite H3 of prodrug clopidogrel. The intrinsic clearance value for the S-methylation of metabolite H3 in microsomes is 98.1fold higher than that for H4
-
-
?
1,3-hexanediol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
1-methylimidazole-2-thiol + S-adenosyl-L-methionine
1-methyl-2-(methylthio)-1H-imidazole + S-adenosyl-L-homocysteine
-
-
-
-
?
2,3-dimercaptopropanol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
2-benzimidazole thiol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptoacetic acid + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptobenzothiazole + S-adenosyl-L-methionine
S-methyl-2-mercaptobenzothiazole + S-adenosyl-L-homocysteine
-
-
-
?
2-mercaptoethanol + S-adenosyl-L-methionine
S-methyl-2-mercaptoethanol + S-adenosyl-L-homocysteine
2-mercaptopropanoic acid + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptopropionic acid + S-adenosyl-L-methionine
S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine
2-thioacetanilide + S-adenosyl-L-methionine
S-methyl-2-thioacetanilide + S-adenosyl-L-homocysteine
-
-
-
-
?
3-mercaptohexan-1-ol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
3-mercaptopropanoic acid + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
3-mercaptopropionic acid methyl ester + S-adenosyl-L-methionine
S-methyl-3-mercaptopropionic acid methyl ester + S-adenosyl-L-homocysteine
-
-
-
-
?
4,4'-thiobisbenzenethiol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
4-chlorothiophenol + S-adenosyl-L-methionine
4-chloro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
-
-
-
?
4-nitrothiophenol + S-adenosyl-L-methionine
4-nitro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
-
-
-
?
6-mercaptohexan-1-ol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
6-propyl-2-thiouracil + S-adenosyl-L-methionine
6-propyl-S-methyl-2-thiouracil + S-adenosyl-L-homocysteine
-
-
-
-
?
6-thiopurine + S-adenosyl-L-methionine
S-methyl-6-thiopurine + S-adenosyl-L-homocysteine
-
-
-
?
benzene thiol + S-adenosyl-L-methionine
methyl phenyl sulfide + S-adenosyl-L-homocysteine
-
-
-
-
?
benzylmercaptan + S-adenosyl-L-methionine
benzylmethylsulfide + S-adenosyl-L-homocysteine
-
-
-
?
bisulfide + S-adenosyl-L-methionine
methanethiol + S-adenosyl-L-homocysteine
highest activity
-
-
?
diethylthiocarbamoyl sulfide + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
dihydroziprasidone + S-adenosyl-L-methionine
S-methyldihydroziprasidone + S-adenosyl-L-homocysteine
-
-
-
-
?
ethanethioic S-acid + S-adenosyl-L-methionine
S-methylethanethioate + S-adenosyl-L-homocysteine
-
-
-
-
?
furfuryl thiol + S-adenosyl-L-methionine
2-[(methylsulfanyl)methyl]furan + S-adenosyl-L-homocysteine
-
-
-
-
?
guaiacol + S-adenosyl-L-methionine
1,2-dimethoxybenzene + S-adenosyl-L-homocysteine
-
-
-
-
?
L-cysteine methyl ester + S-adenosyl-L-methionine
S-methyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine
-
-
-
-
?
mercaptoacetic acid + S-adenosyl-L-methionine
S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine
methylmercaptan + S-adenosyl-L-methionine
dimethylsulfide + S-adenosyl-L-homocysteine
-
i.e. methanethiol
-
-
?
N-acetyl-L-cysteine + S-adenosyl-L-methionine
N-acetyl-S-methyl-L-cysteine + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
pentachlorobenzenethiol + S-adenosyl-L-methionine
1,2,3,4,5-pentachloro-6-(methylthio)benzene + S-adenosyl-L-homocysteine
-
-
-
-
?
phenol + S-adenosyl-L-methionine
methoxybenzene + S-adenosyl-L-homocysteine
-
-
-
-
?
phenyl sulfide + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
S-3'-deoxyadenosyl-L-methionine + 2-mercaptoethanol
S-3'-deoxyadenosyl-L-homocysteine + S-methyl-2-mercaptoethanol
-
-
-
-
?
S-3-deazaadenosyl-L-methionine + 2-mercaptoethanol
S-3-deazaadenosyl-L-homocysteine + S-methyl-2-mercaptoethanol
-
-
-
-
?
S-8-azaadenosyl-L-methionine + 2-mercaptoethanol
S-8-azaadenosyl-L-homocysteine + S-methyl-2-mercaptoethanol
-
-
-
-
?
S-adenosyl-L-methionine + BI 187004
S-adenosyl-L-homocysteine + 1-(1-methyl-1H-benzimidazole-5-carbonyl)-1,2,3,4,5,5a,10,10a-octahydroindeno[2,1-b]azepine-7-carbonitrile
-
BI 187004,i.e. an 11beta-hydroxysteroid dehydrogenase 1 inhibitor
-
-
?
S-adenosyl-L-methionine + bromide
S-adenosyl-L-homocysteine + bromomethane
-
-
-
?
S-adenosyl-L-methionine + chloride
S-adenosyl-L-homocysteine + chloromethane
very low activity
-
-
?
S-adenosyl-L-methionine + iodide
S-adenosyl-L-homocysteine + iodomethane
-
-
-
?
S-aristeromycinyl-L-methionine + 2-mercaptoethanol
S-aristeromycinyl-L-homocysteine + S-methyl-2-mercaptoethanol
-
-
-
-
?
S-N6-methyladenosyl-L-methionine + 2-mercaptoethanol
S-N6-methyladenosyl-L-homocysteine + S-methyl-2-mercaptoethanol
-
-
-
-
?
S-tubercidinyl-L-methionine + 2-mercaptoethanol
S-tubercidinyl-L-homocysteine + S-methyl-2-mercaptoethanol
-
-
-
-
?
thiobenzoic acid + S-adenosyl-L-methionine
methylthiobenzoate + S-adenosyl-L-homocysteine + H+
-
-
-
-
?
thiocyanate + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptoethanol + S-adenosyl-L-methionine
S-methyl-2-mercaptoethanol + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptoethanol + S-adenosyl-L-methionine
S-methyl-2-mercaptoethanol + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptoethanol + S-adenosyl-L-methionine
S-methyl-2-mercaptoethanol + S-adenosyl-L-homocysteine
-
-
i.e. 2-hydroxy-S-methyl-1-thioethane
?
2-mercaptopropionic acid + S-adenosyl-L-methionine
S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine
-
-
-
-
?
2-mercaptopropionic acid + S-adenosyl-L-methionine
S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine
-
-
-
-
?
dithiothreitol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
dithiothreitol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
-
-
-
-
?
H2S + S-adenosyl-L-methionine
methanethiol + S-adenosyl-L-homocysteine
-
-
-
-
?
H2S + S-adenosyl-L-methionine
methanethiol + S-adenosyl-L-homocysteine
-
-
-
?
mercaptoacetic acid + S-adenosyl-L-methionine
S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine
-
-
-
-
?
mercaptoacetic acid + S-adenosyl-L-methionine
S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine
-
i.e. thioglycolic acid
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
O-methylmercaptoethanol + S-adenosyl-L-methionine
2-methoxy-S-methyl-1-thioethane + S-adenosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-methionine + a thiol
S-adenosyl-L-homocysteine + a thioether
-
-
-
-
?
S-adenosyl-L-methionine + a thiol
S-adenosyl-L-homocysteine + a thioether
-
enzyme is not essential as methyl donor or as sulfur transport form, enzyme is involved in regulation of the free Met pool and the S-adenosyl-L-methionine level, SMM cycle, overview
-
-
?
S-adenosyl-L-methionine + a thiol
S-adenosyl-L-homocysteine + a thioether
-
high specificity for S-adenosyl-L-methionine
-
-
?
S-adenosyl-L-methionine + a thiol
S-adenosyl-L-homocysteine + a thioether
-
enzyme is not essential as methyl donor or as sulfur transport form, enzyme is involved in regulation of the free Met pool and the S-adenosyl-L-methionine level, SMM cycle, overview
-
-
?
S-adenosyl-L-methionine + HS-
S-adenosyl-L-homocysteine + CH3SH
-
the enzyme is strictly dependent on S-adenosyl-L-methionine as a methyl donor
-
-
?
S-adenosyl-L-methionine + thiocyanate
S-adenosyl-L-homocysteine + methyl thiocyanate
-
-
-
-
?
S-adenosyl-L-methionine + thiocyanate
S-adenosyl-L-homocysteine + methyl thiocyanate
-
-
-
?
S-adenosyl-L-methionine + thiocyanate
S-adenosyl-L-homocysteine + methyl thiocyanate
-
-
-
?
SH- + S-adenosyl-L-methionine
CH3SH + S-adenosyl-L-homocysteine
-
-
-
?
SH- + S-adenosyl-L-methionine
CH3SH + S-adenosyl-L-homocysteine
-
-
-
?
thiocyanate + S-adenosyl-L-methionine
?
AtHOL1 is involved in glucosinolate metabolism and defense against phytopathogens. CH3Cl synthesized by AtHOL1 could be considered a byproduct of NCS- metabolism
-
-
?
thiocyanate + S-adenosyl-L-methionine
methyl thiocyanate + S-adenosyl-L-homocysteine
-
-
-
?
thiocyanate + S-adenosyl-L-methionine
methyl thiocyanate + S-adenosyl-L-homocysteine
-
-
-
-
?
thiocyanate + S-adenosyl-L-methionine
methyl thiocyanate + S-adenosyl-L-homocysteine
-
-
-
?
thiocyanate + S-adenosyl-L-methionine
methyl thiocyanate + S-adenosyl-L-homocysteine
-
-
-
?
thiocyanate + S-adenosyl-L-methionine
methyl thiocyanate + S-adenosyl-L-homocysteine
-
-
-
?
thiophenol + S-adenosyl-L-methionine
S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
-
-
-
?
thiophenol + S-adenosyl-L-methionine
S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
-
-
?
additional information
?
-
-
also methylates iodide at a rate comparable to that for HS-
-
-
?
additional information
?
-
-
no activity with flavonoids and hydroxyl group-containing compounds, inactive with Na2S and 3-mercaptobenzoic acid, presence of carboxyl groups abolishes CrSMT1 activity, threitol, furfuryl alcohol, benzoic acid, 1,3-propandiol, 1,6-hexanediol and pyrocatechol possess negligible activity
-
-
?
additional information
?
-
-
the bifunctional enzyme also catalyzes the methylation of iodide and to a lesser extent bromide and chloride
-
-
?
additional information
?
-
the enzyme may be involved in the detoxification of sulfur compounds produced by the degradation of glucosinolates to release them as volatile compounds. The volatile sulfur compounds, including CH3SH and CH3SCN and methyl halides, are believed to act as insecticidal or anti-pathogenic agents. Therefore, it is speculated that the enzyme plays a role in controlling the levels of anions that can inhibit metabolic enzymes in the leaves and also to protect them from damage caused by insects or pathogens
-
-
?
additional information
?
-
-
the enzyme may be involved in the detoxification of sulfur compounds produced by the degradation of glucosinolates to release them as volatile compounds. The volatile sulfur compounds, including CH3SH and CH3SCN and methyl halides, are believed to act as insecticidal or anti-pathogenic agents. Therefore, it is speculated that the enzyme plays a role in controlling the levels of anions that can inhibit metabolic enzymes in the leaves and also to protect them from damage caused by insects or pathogens
-
-
?
additional information
?
-
the enzyme also shows halide methyltransferase activity
-
-
?
additional information
?
-
-
the enzyme also shows halide methyltransferase activity
-
-
?
additional information
?
-
the enzyme shows no activity towards CN-
-
-
?
additional information
?
-
-
role in detoxification of hydrogen sulfide that is generated by the colonic flora
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
thiocyanate + S-adenosyl-L-methionine
?
AtHOL1 is involved in glucosinolate metabolism and defense against phytopathogens. CH3Cl synthesized by AtHOL1 could be considered a byproduct of NCS- metabolism
-
-
?
S-adenosyl-L-methionine + a thiol
S-adenosyl-L-homocysteine + a thioether
-
enzyme is not essential as methyl donor or as sulfur transport form, enzyme is involved in regulation of the free Met pool and the S-adenosyl-L-methionine level, SMM cycle, overview
-
-
?
S-adenosyl-L-methionine + a thiol
S-adenosyl-L-homocysteine + a thioether
-
enzyme is not essential as methyl donor or as sulfur transport form, enzyme is involved in regulation of the free Met pool and the S-adenosyl-L-methionine level, SMM cycle, overview
-
-
?
additional information
?
-
the enzyme may be involved in the detoxification of sulfur compounds produced by the degradation of glucosinolates to release them as volatile compounds. The volatile sulfur compounds, including CH3SH and CH3SCN and methyl halides, are believed to act as insecticidal or anti-pathogenic agents. Therefore, it is speculated that the enzyme plays a role in controlling the levels of anions that can inhibit metabolic enzymes in the leaves and also to protect them from damage caused by insects or pathogens
-
-
?
additional information
?
-
-
the enzyme may be involved in the detoxification of sulfur compounds produced by the degradation of glucosinolates to release them as volatile compounds. The volatile sulfur compounds, including CH3SH and CH3SCN and methyl halides, are believed to act as insecticidal or anti-pathogenic agents. Therefore, it is speculated that the enzyme plays a role in controlling the levels of anions that can inhibit metabolic enzymes in the leaves and also to protect them from damage caused by insects or pathogens
-
-
?
additional information
?
-
-
role in detoxification of hydrogen sulfide that is generated by the colonic flora
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
p-hydroxymercuribenzoic acid
-
95% inhibition at 10 mM, reversed in presence of 20 mM Cys
2,3-dichloro-alpha-methylbenzylamine
-
in liver S-9 fraction 90% inhibition at 1 mM
Zn2+
-
ca. 90% inhibition at 1 mM, at low concentrations the effect is substrate-dependent
additional information
-
overview: inhibition by analogs of S-adenosyl-L-homocysteine and analogs of S-adenosyl-L-methionine
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Analysis of Differential Expression Proteins of Paclitaxel-Treated Lung Adenocarcinoma Cell A549 Using Tandem Mass Tag-Based Quantitative Proteomics.
Alzheimer Disease
27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer's Disease.
Alzheimer Disease
Changes in APP, PS1 and other factors related to Alzheimer's disease pathophysiology after trimethyltin-induced brain lesion in the rat.
Alzheimer Disease
Convergent Results from Neuropsychology and from Neuroimaging in Patients with Mild Cognitive Impairment.
Alzheimer Disease
One-year treatment of Alzheimer's disease with acetylcholinesterase inhibitors: improvement on ADAS-cog and TMT A, no change or worsening on other tests.
Alzheimer Disease
Oral trail making task as a discriminative tool for different levels of cognitive impairment and normal aging.
Alzheimer Disease
Organotin compounds in trimethyltin-treated rats and in human brain in Alzheimer's disease.
Alzheimer Disease
Selective behavioural impairment after acute intoxication with trimethyltin (TMT) in rats.
Alzheimer Disease
The use of neuropsychological tests across Europe: the need for a consensus in the use of assessment tools for dementia.
Alzheimer Disease
Trail making test B and brain perfusion imaging in mild cognitive impairment and mild Alzheimer's disease.
Alzheimer Disease
Trail Making Test errors in normal aging, mild cognitive impairment, and dementia.
Alzheimer Disease
Trail making test part a and brain perfusion imaging in mild Alzheimer's disease.
Amnesia
Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study.
Aneurysm
Clinical characteristics of aneurysmal subarachnoid hemorrhage in the elderly over 75; would temporal muscle be a potential prognostic factor as an indicator of sarcopenia?
Angina, Stable
Angiographic severity and morphological spectrum of coronary artery disease in non insulin dependent diabetes mellitus.
Angina, Stable
Comparative evaluation of dopamine infusion & treadmill exercise tests in the diagnosis of coronary artery disease.
Angina, Unstable
Angiographic severity and morphological spectrum of coronary artery disease in non insulin dependent diabetes mellitus.
Anosmia
Comparative Fear-Related Behaviors to Predator Odors (TMT and Natural Fox Feces) before and after Intranasal ZnSO(4) Treatment in Mice.
Arthritis
Biomechanical Evaluation of Tarsometatarsal Fusion Comparing Crossing Lag Screws and Lag Screw With Locking Plate.
Arthritis
Clinical and Radiological Outcomes after Open Reduction and Internal Fixation of Lisfranc Injuries: A Single Centre Experience.
Arthritis
The injuries to the fourth and fifth tarsometatarsal joints: A review of the surgical management by internal fixation, arthrodesis and arthroplasty.
Arthritis, Juvenile
Stomatognathic function in juvenile rheumatoid arthritis and in developmental open-bite subjects.
Astrocytoma
PAR-1 upregulation by trimethyltin and lipopolysaccharide in cultured rat astrocytes.
Atherosclerosis
Total atherosclerotic burden measured by magnetic resonance imaging is related to five-year decline in cognitive function.
Atherosclerosis
[Current aspects of performing treadmill test in patients with peripheral artery disease].
Atrial Fibrillation
Quantitative proteomic analysis to identify differentially expressed proteins in the persistent atrial fibrillation using TMT coupled with nano-LC-MS/MS.
Barth Syndrome
AAV9-TAZ Gene Replacement Ameliorates Cardiac TMT Proteomic Profiles in a Mouse Model of Barth Syndrome.
Blister
In vitro organotin administration alters guinea pig cochlear outer hair cell shape and viability.
Bone Resorption
Clinical and radiographic evaluation of single tantalum dental implants: a prospective pilot clinical study.
Bradycardia
Mechanism in bradycardia induced by Trimethyltin chloride: Inhibition activity and expression of Na+/K+-ATPase and apoptosis in myocardia.
Brain Diseases
Development of an analytical method to confirm toxic trimethylated tin in human urine.
Brain Injuries
Acute administration of tributyltin and trimethyltin modulate glutamate and N-methyl-D-aspartate receptor signaling pathway in Sebastiscus marmoratus.
Brain Injuries
Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study.
Brain Injuries
Neuronal degeneration and glial cell-responses following trimethyltin intoxication in the rat.
Brain Injuries
Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.
Brain Injuries, Traumatic
Attentional control and slowness of information processing after severe traumatic brain injury.
Brain Injuries, Traumatic
Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study.
Brain Neoplasms
High correlation of temporal muscle thickness with lumbar skeletal muscle cross-sectional area in patients with brain metastases.
Brain Neoplasms
Incidence of Brain Metastases after Trimodality Therapy in Patients with Esophageal or Gastroesophageal Cancer: Implications for Screening and Surveillance.
Brain Neoplasms
Prognostic relevance of temporal muscle thickness as a marker of sarcopenia in patients with glioblastoma at diagnosis.
Brain Neoplasms
Temporal muscle thickness is an independent prognostic marker in melanoma patients with newly diagnosed brain metastases.
Breast Neoplasms
Characterization of Breast Cancer Interstitial Fluids by TmT Labeling, LTQ-Orbitrap Velos Mass Spectrometry, and Pathway Analysis.
Breast Neoplasms
Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling.
Breast Neoplasms
Peptide functionalized poly ethylene glycol-poly caprolactone nanomicelles for specific cabazitaxel delivery to metastatic breast cancer cells.
Breast Neoplasms
Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.
Breast Neoplasms
Survival prediction using temporal muscle thickness measurements on cranial magnetic resonance images in patients with newly diagnosed brain metastases.
Bunion
Relationship of Radiographic and Clinical Parameters With Hallux Valgus and Second Ray Pathology.
Carcinogenesis
Differential expression of O6-methylguanine-DNA methyltransferase during diethylnitrosamine-induced carcinogenesis and liver regeneration in Sprague-Dawley male rats.
Carcinogenesis
Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk.
Carcinogenesis
Phosphorylation of methylated-DNA-protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion.
Carcinoma
A single-institute experience of trimodal bladder-preserving therapy for histologic variants of urothelial carcinoma.
Carcinoma
Analysis of trimodal and bimodal therapy in a selective-surgery paradigm for locally advanced oesophageal squamous cell carcinoma.
Carcinoma
Canadian experience of neoadjuvant chemotherapy on bladder recurrences in patients managed with trimodal therapy for muscle-invasive bladder cancer.
Carcinoma
Clinical Outcomes of Patients with Histologic Variants of Urothelial Cancer Treated with Trimodality Bladder-sparing Therapy.
Carcinoma
Neoadjuvant targeted molecular therapies in patients undergoing nephrectomy and inferior vena cava thrombectomy: is it useful?
Carcinoma
Pathological stage after neoadjuvant chemoradiation and esophagectomy superiorly predicts survival in patients with esophageal squamous cell carcinoma.
Carcinoma
Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.
Carcinoma
Surgical challenges and considerations in Tri-modal therapy for muscle invasive bladder cancer.
Carcinoma
Trimodality Treatment for Muscle-Invasive Bladder Cancer: An Institutional Experience.
Carcinoma in Situ
Canadian experience of neoadjuvant chemotherapy on bladder recurrences in patients managed with trimodal therapy for muscle-invasive bladder cancer.
Carcinoma in Situ
Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.
Carcinoma in Situ
Surgical challenges and considerations in Tri-modal therapy for muscle invasive bladder cancer.
Carcinoma in Situ
Trimodality Treatment for Muscle-Invasive Bladder Cancer: An Institutional Experience.
Carcinoma, Non-Small-Cell Lung
Survival prediction using temporal muscle thickness measurements on cranial magnetic resonance images in patients with newly diagnosed brain metastases.
Carcinoma, Non-Small-Cell Lung
Trimodality vs Chemoradiation and Salvage Resection in cN2 Stage IIIA Non-Small Cell Lung Cancer.
Carcinoma, Renal Cell
Neoadjuvant targeted molecular therapies in patients undergoing nephrectomy and inferior vena cava thrombectomy: is it useful?
Cardiovascular Diseases
Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish.
Causalgia
Successful Graded Mirror Therapy in a Patient with Chronic Deafferentation Pain in Whom Traditional Mirror Therapy was Ineffective: A Case Report.
Central Nervous System Diseases
NLRP3 inflammasome activation is involved in trimethyltin-induced neuroinflammation.
Choriocarcinoma
Quantitative proteomic analysis identifies novel regulators of methotrexate resistance in choriocarcinoma.
Colorectal Neoplasms
A circulating extracellular vesicles-based novel screening tool for colorectal cancer revealed by shotgun and data-independent acquisition mass spectrometry.
Colorectal Neoplasms
Proteomic screening of potential N-glycoprotein biomarkers for colorectal cancer by TMT labeling combined with LC-MS/MS.
Colorectal Neoplasms
Systematic Comparison of Label-Free, SILAC, and TMT Techniques to Study Early Adaption toward Inhibition of EGFR Signaling in the Colorectal Cancer Cell Line DiFi.
Colorectal Neoplasms
THBS1 facilitates colorectal liver metastasis through enhancing epithelial-mesenchymal transition.
Coma
Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study.
Confusion
Cognitive function and mood at high altitude following acclimatization