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Literature summary for 2.1.1.9 extracted from

  • Coiner, H.; Schroeder, G.; Wehinger, E.; Liu, C.J.; Noel, J.P.; Schwab, W.; Schroeder, J.
    Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases (2006), Plant J., 46, 193-205.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information a few changes in key residues are sufficient to convert an OMT into a S-methyltransferase Catharanthus roseus

Cloned(Commentary)

Cloned (Comment) Organism
subcloned for expression of a His-tagged recombinant protein in Escherichia coli Catharanthus roseus

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by Mg2+ Catharanthus roseus
Zn2+ ca. 90% inhibition at 1 mM, at low concentrations the effect is substrate-dependent Catharanthus roseus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.056
-
furfuryl thiol
-
Catharanthus roseus
0.096
-
S-adenosyl-L-methionine when assayed with benzene thiol and furfuryl thiol Catharanthus roseus
0.218
-
benzene thiol
-
Catharanthus roseus

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to near homogeneity by Ni-chelation affinity chromatography Catharanthus roseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3-hexanediol + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
2-mercaptoacetic acid + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
2-mercaptopropanoic acid + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
3-mercaptohexan-1-ol + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
3-mercaptopropanoic acid + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
6-mercaptohexan-1-ol + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
benzene thiol + S-adenosyl-L-methionine
-
Catharanthus roseus methyl phenyl sulfide + S-adenosyl-L-homocysteine
-
?
dithiothreitol + S-adenosyl-L-methionine
-
Catharanthus roseus ? + S-adenosyl-L-homocysteine
-
?
ethanethioic S-acid + S-adenosyl-L-methionine
-
Catharanthus roseus S-methylethanethioate + S-adenosyl-L-homocysteine
-
?
furfuryl thiol + S-adenosyl-L-methionine
-
Catharanthus roseus 2-[(methylsulfanyl)methyl]furan + S-adenosyl-L-homocysteine
-
?
guaiacol + S-adenosyl-L-methionine
-
Catharanthus roseus 1,2-dimethoxybenzene + S-adenosyl-L-homocysteine
-
?
additional information no activity with flavonoids and hydroxyl group-containing compounds, inactive with Na2S and 3-mercaptobenzoic acid, presence of carboxyl groups abolishes CrSMT1 activity, threitol, furfuryl alcohol, benzoic acid, 1,3-propandiol, 1,6-hexanediol and pyrocatechol possess negligible activity Catharanthus roseus ?
-
?
phenol + S-adenosyl-L-methionine
-
Catharanthus roseus methoxybenzene + S-adenosyl-L-homocysteine
-
?

Synonyms

Synonyms Comment Organism
CrSMT1
-
Catharanthus roseus
S-methyltransferase 1
-
Catharanthus roseus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
with furfuryl thiol as substrate Catharanthus roseus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
10 30 with furfuryl thiol as substrate Catharanthus roseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.3 with furfuryl thiol as substrate Catharanthus roseus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 11 with furfuryl thiol as substrate Catharanthus roseus