Literature summary for 2.1.1.9 extracted from

Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase (2018), Drug Metab. Dispos., 46, 770-778 .

Search for more literature for 2.1.1.9

Application

Application	Comment	Organism
medicine	in some patients with type 2 diabetes mellitus who are treated with 11beta-hydroxysteroid dehydrogenase inhibitor BI 187004, the plasma exposure of N-methylbenzimidazole metabolite 1-(1-methyl-1H-benzimidazole-5-carbonyl)-1,2,3,4,5,5a,10,10a-octahydroindeno[2,1-b]azepine-7-carbonitrile is 7fold higher than in the other patients. Thiol S-transferase catalyzes the formation of the metabolite	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-dichloro-alpha-methylbenzylamine	inhibits the reaction with BI 187004	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + BI 187004	BI 187004,i.e. an 11beta-hydroxysteroid dehydrogenase 1 inhibitor	Homo sapiens	S-adenosyl-L-homocysteine + 1-(1-methyl-1H-benzimidazole-5-carbonyl)-1,2,3,4,5,5a,10,10a-octahydroindeno[2,1-b]azepine-7-carbonitrile	-	?

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Release 2023.1 (January 2023)