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Information on EC - 2,4,6-trichlorophenol monooxygenase

for references in articles please use BRENDA:EC1.14.14.173
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IUBMB Comments
The enzyme, characterized from a number of bacterial species, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative. The enzyme is a multifunctional flavin-dependent monooxygenase that displaces two chlorine atoms by attacking two different positions in the substrate. Each reaction catalysed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH2 before the monooxygenase could catalyse the second reaction. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpB). cf. EC, 3,5,6-trichloropyridin-2-ol monooxygenase.
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The expected taxonomic range for this enzyme is: Cupriavidus
2,4,6-tcp monooxygenase, 2,4,6-trichlorophenol monooxygenase, 2,4,6-tcp 4-monooxygenase, tcp-4-monooxygenase, 2,4,6-trichlorophenol-4-monooxygenase, more
2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichloro-1,4-benzoquinone + Cl- + FAD + H2O
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2,6-dichlorohydroquinone + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + Cl- + FAD + H2O
show the reaction diagram
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