Information on EC 1.1.1.202 - 1,3-propanediol dehydrogenase

Reaction Schemes

hideshow

propane-1,3-diol

+

NAD+

=

3-hydroxypropanal

+

NADH

+

H+

+

=

+

+

Synonyms
1,3-propanediol oxidoreductase, 1,3-propanediol dehydrogenase, 1,3-pd oxidoreductase, lr_1734, lr_0030, 1,3-pd dehydrogenase, 1,3-propanediol-oxidoreductase, nadh-dependent 1,3-propanediol oxidoreductase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

(NADH)-linked 1,3-PD oxidoreductase

Klebsiella pneumoniae

-

-

695716

1,3-PD dehydrogenase

3 entries

1,3-PD oxidoreductase

4 entries

1,3-PD-DH

Klebsiella pneumoniae

-

-

684171

1,3-PD:NAD+ oxidoreductase

-

-

-

-

1,3-PDDH

2 entries

1,3-Pdiol dehydrogenase

2 entries

1,3-propanediol dehydrogenase

-

-

-

-

1,3-propanediol oxidoreductase

11 entries

1,3-propanediol-oxidoreductase

2 entries

1,3-propanediol-oxydoreductase

13 entries

1,3-propanediol:NAD oxidoreductase

-

-

-

-

3-hydroxypropionaldehyde reductase

-

-

-

-

ADH3

2 entries

dehydrogenase, 1,3-propanediol

-

-

-

-

DhaT

23 entries

lr_0030

Limosilactobacillus reuteri

-

-

725880

lr_1734

Limosilactobacillus reuteri

-

-

725880

NADH-dependent 1,3-PD dehydrogenase

2 entries

NADH-dependent 1,3-propanediol oxidoreductase

2 entries

NADH-linked 1,3-propanediol oxidoreductase

Klebsiella pneumoniae

-

-

699149

PDOR

22 entries

YqhD

3 entries

1,3-PD dehydrogenase

Clostridium butyricum

-

-

761555

1,3-PD dehydrogenase

Clostridium butyricum 15-42

-

-

-

1,3-PD dehydrogenase

Klebsiella pneumoniae

Q7WRJ3

-

698602

1,3-PD oxidoreductase

Escherichia coli

-

-

695844

1,3-PD oxidoreductase

Klebsiella pneumoniae

-

-

675901, 695842, 695844, 696785

1,3-PD oxidoreductase

Klebsiella pneumoniae Cu

-

-

-

1,3-PD oxidoreductase

Klebsiella pneumoniae KG1

-

-

-

1,3-PDDH

Clostridium butyricum

-

-

761555

1,3-PDDH

Clostridium butyricum 15-42

-

-

-

1,3-Pdiol dehydrogenase

Clostridium butyricum

-

-

667270

1,3-Pdiol dehydrogenase

Clostridium butyricum VPI 3266

-

-

-

1,3-propanediol oxidoreductase

-

-

-

-

1,3-propanediol oxidoreductase

Citrobacter freundii

P45513

-

740927

1,3-propanediol oxidoreductase

Escherichia coli

-

-

695764, 695844

1,3-propanediol oxidoreductase

Escherichia coli SYU 21132

-

-

-

1,3-propanediol oxidoreductase

Klebsiella pneumoniae

-

-

657406, 664422, 670216, 695844, 696785, 697666, 699357

1,3-propanediol oxidoreductase

Klebsiella pneumoniae

Q59477

-

740216

1,3-propanediol oxidoreductase

Klebsiella pneumoniae

Q7WRJ3

-

655107

1,3-propanediol oxidoreductase

Klebsiella pneumoniae DSM 2026

-

-

-

1,3-propanediol oxidoreductase

Klebsiella pneumoniae J2B

Q59477

-

-

1,3-propanediol oxidoreductase

Klebsiella pneumoniae KG1

-

-

-

1,3-propanediol oxidoreductase

Klebsiella pneumoniae M5a1

-

-

-

1,3-propanediol-oxidoreductase

Klebsiella pneumoniae

-

-

657406

1,3-propanediol-oxidoreductase

Klebsiella pneumoniae DSM 2026

-

-

-

1,3-propanediol-oxydoreductase

Citrobacter freundii

-

-

740214

1,3-propanediol-oxydoreductase

Citrobacter freundii DSM 30040

-

-

-

1,3-propanediol-oxydoreductase

Clostridium butyricum

-

-

740214

1,3-propanediol-oxydoreductase

Clostridium butyricum E5

-

-

-

1,3-propanediol-oxydoreductase

Clostridium pasteurianum

-

-

740214

1,3-propanediol-oxydoreductase

Clostridium perfringens

-

-

740214

1,3-propanediol-oxydoreductase

Klebsiella pneumoniae

-

-

740214

1,3-propanediol-oxydoreductase

Klebsiella pneumoniae DSM2026

-

-

-

1,3-propanediol-oxydoreductase

Lentilactobacillus buchneri

-

-

740214

1,3-propanediol-oxydoreductase

Levilactobacillus brevis

-

-

740214

1,3-propanediol-oxydoreductase

Limosilactobacillus reuteri

-

-

740214

1,3-propanediol-oxydoreductase

Pantoea agglomerans

-

-

740214

1,3-propanediol-oxydoreductase

Thermotoga maritima

-

-

740214

ADH3

Oenococcus oeni

A0NIJ1

-

721395

ADH3

Oenococcus oeni ATCC BAA-1163

A0NIJ1

-

-

DhaT

Citrobacter freundii

-

-

740214

DhaT

Citrobacter freundii

P45513

-

725951, 740927

DhaT

Citrobacter freundii DSM 30040

-

-

-

DhaT

Clostridium butyricum

-

-

740214, 760717, 761555

DhaT

Clostridium butyricum 15-42

-

-

-

DhaT

Clostridium butyricum E5

-

-

-

DhaT

Clostridium butyricum YJH-09

-

-

-

DhaT

Clostridium pasteurianum

-

-

740214

DhaT

Clostridium perfringens

-

-

740214

DhaT

Klebsiella pneumoniae

-

-

695842, 695844, 740214, 747304

DhaT

Klebsiella pneumoniae

Q59477

-

710972, 724566, 740216

DhaT

Klebsiella pneumoniae Cu

-

-

-

DhaT

Klebsiella pneumoniae DSM2026

-

-

-

DhaT

Klebsiella pneumoniae J2B

Q59477

-

-

DhaT

Lentilactobacillus buchneri

-

-

740214

DhaT

Levilactobacillus brevis

-

-

740214

DhaT

Levilactobacillus brevis

A0A0C1Q6R1

-

739886

DhaT

Levilactobacillus brevis 6239

A0A0C1Q6R1

-

-

DhaT

Limosilactobacillus reuteri

-

-

740214

DhaT

Oenococcus oeni

A0NIJ1

-

721395

DhaT

Oenococcus oeni ATCC BAA-1163

A0NIJ1

-

-

DhaT

Pantoea agglomerans

-

-

740214

DhaT

Thermotoga maritima

-

-

740214

NADH-dependent 1,3-PD dehydrogenase

Clostridium butyricum

-

-

760717

NADH-dependent 1,3-PD dehydrogenase

Clostridium butyricum YJH-09

-

-

-

NADH-dependent 1,3-propanediol oxidoreductase

Klebsiella pneumoniae

-

-

747304

NADH-dependent 1,3-propanediol oxidoreductase

Klebsiella pneumoniae J2B

-

-

-

PDOR

Citrobacter freundii

-

-

740214

PDOR

Citrobacter freundii

P45513

-

725951, 740927

PDOR

Citrobacter freundii DSM 30040

-

-

-

PDOR

Clostridium butyricum

-

-

740214, 760717

PDOR

Clostridium butyricum E5

-

-

-

PDOR

Clostridium butyricum YJH-09

-

-

-

PDOR

Clostridium pasteurianum

-

-

740214

PDOR

Clostridium perfringens

-

-

740214

PDOR

Klebsiella pneumoniae

-

-

664422, 684524, 695716, 696785, 697666, 699149, 699357, 740214

PDOR

Klebsiella pneumoniae

A3RL85

-

688171

PDOR

Klebsiella pneumoniae

Q7WRJ3

-

655107

PDOR

Klebsiella pneumoniae DSM2026

-

-

-

PDOR

Klebsiella pneumoniae KG1

-

-

-

PDOR

Klebsiella pneumoniae M5a1

-

-

-

PDOR

Klebsiella pneumoniae TUAC01

A3RL85

-

-

PDOR

Lentilactobacillus buchneri

-

-

740214

PDOR

Levilactobacillus brevis

-

-

740214

PDOR

Levilactobacillus brevis

A0A0C1Q6R1

-

739886

PDOR

Levilactobacillus brevis 6239

A0A0C1Q6R1

-

-

PDOR

Limosilactobacillus reuteri

-

-

740214

PDOR

Pantoea agglomerans

-

-

740214

PDOR

Thermotoga maritima

-

-

740214

YqhD

Escherichia coli

-

-

695764, 695844, 710972

YqhD

Escherichia coli SYU 21132

-

-

-

YqhD

Klebsiella pneumoniae

A7LGK0

-

747304

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

-

-

-

-

redox reaction

-

-

-

-

reduction

-

-

-

-

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PATHWAY SOURCE

PATHWAYS

KEGG

Glycerolipid metabolism, Propanoate metabolism

MetaCyc

glycerol degradation III

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SYSTEMATIC NAME

IUBMB Comments

propane-1,3-diol:NAD+ 1-oxidoreductase

-

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CAS REGISTRY NUMBER

COMMENTARY

81611-70-3

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

1,2-propanediol + NAD+

2-hydroxypropanal + NADH

2 entries

1,2-propylene glycol + NAD+

? + NADH + H+

12 entries

1,3-propanediol + NAD+

3-hydroxypropanal + NADH

2 entries

1,3-propanediol + NAD+

3-hydroxypropanal + NADH + H+

Klebsiella pneumoniae

Q59477

724566

Substrates: -
Products: -

?

1,4-butanediol + NAD+

4-hydroxybutanal + NADH

3 entries

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

11 entries

1-butanol + NAD+

1-butanal + NADH + H+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

1-butanol + NAD+

NADH + butanal

3 entries

1-butyl alcohol + NAD+

1-butanal + NADH + H+

10 entries

1-propanol + NAD+

1-propanal + NADH + H+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

1-propanol + NAD+

NADH + propanal

5 entries

1-propanol + NAD+

propanal + NADH + H+

13 entries

2,3-butanediol + NAD+

? + NADH

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

2-butanol + NAD+

NADH + butanone

3 entries

3-hydroxypropanal + NADH

propane-1,3-diol + NAD+

2 entries

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

38 entries

3-hydroxypropanal + NADPH + H+

propane-1,3-diol + NADP+

4 entries

3-hydroxypropionaldehyde + NADH

propane-1,3-diol + NAD+

4 entries

3-hydroxypropionaldehyde + NADH + H+

propane-1,3-diol + NAD+

4 entries

acetaldehyde + NADH + H+

ethanol + NAD+

2 entries

acetone + NADH + H+

?

Clostridium butyricum

-

760717

Substrates: 25.3% activity compared to propionaldehyde
Products: -

?

acetone + NADH + H+

? + NAD+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

butyraldehyde + NADH + H+

butan-1-ol + NAD+

Klebsiella pneumoniae

Q59477

740216

Substrates: -
Products: -

?

dihydroxyacetone + NADH + H+

? + NAD+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

ethanol + NAD+

acetaldehyde + NADH + H+

2 entries

ethanol + NAD+

NADH + ethanal

2 entries

ethylene glycol + NAD+

NADH + ?

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

formaldehyde + NADH + H+

methanol + NAD+

2 entries

glyceraldehyde + NADH + H+

? + NAD+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

glycerol + NAD+

dihydroxyacetone + NADH + H+

4 entries

glycerol + NAD+

glyceraldehyde + NADH + H+

13 entries

glycerol + NADH

propane-1,3-diol + NAD+

2 entries

hydroxyacetone + NADH + H+

?

Clostridium butyricum

-

760717

Substrates: 30.6% activity compared to propionaldehyde
Products: -

?

hydroxyacetone + NADH + H+

? + NAD+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

propane-1,2-diol + NAD+

2-hydroxypropanal + NADH

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

propane-1,2-diol + NAD+

2-hydroxypropanal + NADH + H+

3 entries

propane-1,3-diol + NAD+

3-hydroxypropanal + NADH

15 entries

propane-1,3-diol + NAD+

3-hydroxypropanal + NADH + H+

20 entries

propane-1,3-diol + NAD+ + H+

3-hydroxypropanal + NADH

Klebsiella pneumoniae

Q7WRJ3

698602

Substrates: -
Products: -

?

propane-1,3-diol + NADP+

3-hydroxypropanal + NADPH + H+

Klebsiella pneumoniae

Q7WRJ3

712531

Substrates: NADP+ is not substrate for wild-type, but for mutant D41G
Products: -

r

propionaldehyde + NADH + H+

propan-1-ol + NAD+

2 entries

valeraldehyde + NADH + H+

pentan-1-ol + NAD+

Klebsiella pneumoniae

Q59477

740216

Substrates: -
Products: -

?

additional information

?

-

11 entries

1,2-propanediol + NAD+

2-hydroxypropanal + NADH

Oenococcus oeni

A0NIJ1

721395

Substrates: -
Products: -

?

1,2-propanediol + NAD+

2-hydroxypropanal + NADH

Oenococcus oeni ATCC BAA-1163

A0NIJ1

721395

Substrates: -
Products: -

?

1,2-propylene glycol + NAD+

? + NADH + H+

Citrobacter freundii

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Citrobacter freundii DSM 30040

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Clostridium butyricum

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Clostridium pasteurianum

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Clostridium perfringens

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Klebsiella pneumoniae

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Klebsiella pneumoniae DSM2026

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Lentilactobacillus buchneri

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Levilactobacillus brevis

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Limosilactobacillus reuteri

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Pantoea agglomerans

-

740214

Substrates: -
Products: -

r

1,2-propylene glycol + NAD+

? + NADH + H+

Thermotoga maritima

-

740214

Substrates: -
Products: -

r

1,3-propanediol + NAD+

3-hydroxypropanal + NADH

Oenococcus oeni

A0NIJ1

721395

Substrates: activity with 1,3-propanediol is highly dependent on the presence of Ni2+
Products: -

?

1,3-propanediol + NAD+

3-hydroxypropanal + NADH

Oenococcus oeni ATCC BAA-1163

A0NIJ1

721395

Substrates: activity with 1,3-propanediol is highly dependent on the presence of Ni2+
Products: -

?

1,4-butanediol + NAD+

4-hydroxybutanal + NADH

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH

Lentilactobacillus buchneri

-

389498

Substrates: -
Products: -

?

1,4-butanediol + NAD+

4-hydroxybutanal + NADH

Levilactobacillus brevis

-

389498

Substrates: -
Products: -

?

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Citrobacter freundii

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Clostridium butyricum

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Clostridium pasteurianum

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Clostridium perfringens

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Klebsiella pneumoniae

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Lentilactobacillus buchneri

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Levilactobacillus brevis

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Limosilactobacillus reuteri

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Pantoea agglomerans

-

740214

Substrates: -
Products: -

r

1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+

Thermotoga maritima

-

740214

Substrates: -
Products: -

r

1-butanol + NAD+

NADH + butanal

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

1-butanol + NAD+

NADH + butanal

Lentilactobacillus buchneri

-

389498

Substrates: -
Products: -

?

1-butanol + NAD+

NADH + butanal

Levilactobacillus brevis

-

389498

Substrates: -
Products: -

?

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Citrobacter freundii

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Clostridium butyricum

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Clostridium pasteurianum

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Clostridium perfringens

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Klebsiella pneumoniae

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Lentilactobacillus buchneri

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Levilactobacillus brevis

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Limosilactobacillus reuteri

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Pantoea agglomerans

-

740214

Substrates: -
Products: -

r

1-butyl alcohol + NAD+

1-butanal + NADH + H+

Thermotoga maritima

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

NADH + propanal

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

1-propanol + NAD+

NADH + propanal

Clostridium butyricum

-

389496

Substrates: -
Products: -

?

1-propanol + NAD+

NADH + propanal

Clostridium butyricum E5

-

389496

Substrates: -
Products: -

?

1-propanol + NAD+

NADH + propanal

Lentilactobacillus buchneri

-

389498

Substrates: -
Products: -

?

1-propanol + NAD+

NADH + propanal

Levilactobacillus brevis

-

389498

Substrates: -
Products: -

?

1-propanol + NAD+

propanal + NADH + H+

Citrobacter freundii

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Citrobacter freundii DSM 30040

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Clostridium butyricum

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Clostridium butyricum E5

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Clostridium pasteurianum

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Clostridium perfringens

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Klebsiella pneumoniae

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Klebsiella pneumoniae DSM2026

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Lentilactobacillus buchneri

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Levilactobacillus brevis

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Limosilactobacillus reuteri

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Pantoea agglomerans

-

740214

Substrates: -
Products: -

r

1-propanol + NAD+

propanal + NADH + H+

Thermotoga maritima

-

740214

Substrates: -
Products: -

r

2-butanol + NAD+

NADH + butanone

Citrobacter freundii

-

389494

Substrates: -
Products: -

?

2-butanol + NAD+

NADH + butanone

Clostridium butyricum

-

389496

Substrates: -
Products: -

?

2-butanol + NAD+

NADH + butanone

Clostridium butyricum E5

-

389496

Substrates: -
Products: -

?

3-hydroxypropanal + NADH

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

696785

Substrates: overexpression of PDOR does not affect the concentration of propane-1,3-diol, but it enhances the molar yield from 50.6 to 64.0% and reduces the concentration of by-products, among them, the concentrations of lactic acid, ethanol and succinic acid are decreased by 51.8, 50.6 and 47.4%, respectively. Activity of recombinant PDOR is 44fold higher than those of the wild-type. PDOR overexpression leads to a slower cell growth and lower productivity, and during the fed-batch fermentation in 3.7 l bioreactor, a growth stagnation is observed
Products: -

?

3-hydroxypropanal + NADH

propane-1,3-diol + NAD+

Klebsiella pneumoniae KG1

-

696785

Substrates: overexpression of PDOR does not affect the concentration of propane-1,3-diol, but it enhances the molar yield from 50.6 to 64.0% and reduces the concentration of by-products, among them, the concentrations of lactic acid, ethanol and succinic acid are decreased by 51.8, 50.6 and 47.4%, respectively. Activity of recombinant PDOR is 44fold higher than those of the wild-type. PDOR overexpression leads to a slower cell growth and lower productivity, and during the fed-batch fermentation in 3.7 l bioreactor, a growth stagnation is observed
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Citrobacter freundii

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Citrobacter freundii

P45513

725951, 740927

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Citrobacter freundii DSM 30040

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Clostridium butyricum

-

740214, 760717

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Clostridium butyricum E5

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Clostridium butyricum YJH-09

-

760717

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Clostridium pasteurianum

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Clostridium perfringens

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

695842

Substrates: -
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

675901, 684171, 684524, 740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

Q7WRJ3

655107, 712531

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

712531

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

A3RL85

688171

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

Q59477

740216

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

A7LGK0

747304

Substrates: -
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

Q7WRJ3

655107

Substrates: part of the conversion of glycerol to 1,3-propanediol, not the limiting step
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

A3RL85

688171

Substrates: 3-hydroxypropionaldehyde is an inhibitory intermediary metabolite in the 1,3-propanediol synthesis pathway during fermentation of raw material required for the synthesis of polytrimethylene terephthalate and other polyester fibers, accumulation of 3-hydroxypropanal in broth causes an irreversible cessation of the fermentation process
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

684171

Substrates: a key enzyme in the reductive pathway of anaerobic glycerol dissimilation converting glycerol to 1,3-propanediol in the human pathogen Klebsiella pneumoniae
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

699149

Substrates: activity of PDOR in KG1 (pUC18K-dhaT) is 44fold higher than that of the wild-type strain. In the resting cell system, overexpression of 1,3-propanediol oxidoreductase leads to faster glycerol conversion and propane-1,3-diol production. After a 12 h conversion process, it improves the yield of propane-1,3-diol by 20.4% and enhances the conversion ratio of glycerol into propane-1,3-diol from 50.8% to 59.8%
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

699357

Substrates: in the cell exponential growth phase, the reaction catalyzed by 1,3-propanediol oxidoreductase is the rate limiting step in 1,3-propanediol production
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

695716

Substrates: level of PDOR activity of Klebsiella pneumoniae/pETPkan-dhaT (1.64 U/mg) shows an increase of 0.9fold in PDOR activity with respect to the wild-type Klebsiella pneumoniae (0.85 U/mg). The recombinant strain Klebsiella pneumoniae/pETPkan-dhaT improves propane-1,3-diol production by 16.5% with respect to the wild-type strain
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

697666

Substrates: overexpression of PDOR increases activity by 3.2fold, enzyme activity ratio of PDOR/GDHt (glycerol dehydratase) also is increased. 3-hydroxypropanal accumulation is successfully decreased and the risk of fermentation cease is reduced at the same time by overexpression of PDOR and GDH (glycerol dehydrogenase)
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

Q59477

740216

Substrates: under physiological conditions, DhaT mostly catalyzes the forward reaction
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae Cu

-

695842

Substrates: -
Products: -

?

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae DSM2026

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae J2B

Q59477

740216

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae J2B

Q59477

740216

Substrates: under physiological conditions, DhaT mostly catalyzes the forward reaction
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae TUAC01

A3RL85

688171

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae TUAC01

A3RL85

688171

Substrates: 3-hydroxypropionaldehyde is an inhibitory intermediary metabolite in the 1,3-propanediol synthesis pathway during fermentation of raw material required for the synthesis of polytrimethylene terephthalate and other polyester fibers, accumulation of 3-hydroxypropanal in broth causes an irreversible cessation of the fermentation process
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Lentilactobacillus buchneri

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Levilactobacillus brevis

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: reduction of the aldehyde is the preferred reaction
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: reduction of the aldehyde is the preferred reaction, 3-hydroxypropanal is the preferred substrate
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Levilactobacillus brevis 6239

A0A0C1Q6R1

739886

Substrates: reduction of the aldehyde is the preferred reaction
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Levilactobacillus brevis 6239

A0A0C1Q6R1

739886

Substrates: reduction of the aldehyde is the preferred reaction, 3-hydroxypropanal is the preferred substrate
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Limosilactobacillus reuteri

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Pantoea agglomerans

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+

Thermotoga maritima

-

740214

Substrates: -
Products: -

r

3-hydroxypropanal + NADPH + H+

propane-1,3-diol + NADP+

Escherichia coli

-

695764

Substrates: improvement of propane-1,3-diol production by a novel propane-1,3-diol operon of three genes (dhaB1 and dhaB2 from Clostridium butyricum and YqhD from Escherichia coli) tandemly arrayed under the control of a constitutive, temperature-sensitive promoter in the vector pBV220 for heterologous expression in Escherichia coli
Products: -

?

3-hydroxypropanal + NADPH + H+

propane-1,3-diol + NADP+

Escherichia coli

-

695844

Substrates: the Escherichia coli yqhD homolog can replace the function of DhaT in the Klebsiella pneumoniae AK mutant strain defective in 1,3-PD oxidoreductase activity (DhaT). The yqhD homolog restores propane-1,3-diol production and 1,3-PD oxidoreductase activity. Level of propane-1,3-diol production during batch fermentation in the recombinant strain is comparable to that of the parent strain
Products: -

?

3-hydroxypropanal + NADPH + H+

propane-1,3-diol + NADP+

Escherichia coli SYU 21132

-

695764

Substrates: improvement of propane-1,3-diol production by a novel propane-1,3-diol operon of three genes (dhaB1 and dhaB2 from Clostridium butyricum and YqhD from Escherichia coli) tandemly arrayed under the control of a constitutive, temperature-sensitive promoter in the vector pBV220 for heterologous expression in Escherichia coli
Products: -

?

3-hydroxypropanal + NADPH + H+

propane-1,3-diol + NADP+

Klebsiella pneumoniae

Q7WRJ3

712531

Substrates: NADPH is not substrate for wild-type, but for mutant D41G
Products: -

r

3-hydroxypropionaldehyde + NADH

propane-1,3-diol + NAD+

Clostridium butyricum

-

667270

Substrates: recombinant mutant Clostridium acetobutylicum strain DG1(pSPD5) expressing the enzyme from an introduced plasmid
Products: -

?

3-hydroxypropionaldehyde + NADH

propane-1,3-diol + NAD+

Clostridium butyricum VPI 3266

-

667270

Substrates: recombinant mutant Clostridium acetobutylicum strain DG1(pSPD5) expressing the enzyme from an introduced plasmid
Products: -

?

3-hydroxypropionaldehyde + NADH

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

664422

Substrates: -
Products: -

?

3-hydroxypropionaldehyde + NADH

propane-1,3-diol + NAD+

Klebsiella pneumoniae M5a1

-

664422

Substrates: -
Products: -

?

3-hydroxypropionaldehyde + NADH + H+

propane-1,3-diol + NAD+

Clostridium butyricum

-

761555

Substrates: -
Products: -

?

3-hydroxypropionaldehyde + NADH + H+

propane-1,3-diol + NAD+

Clostridium butyricum 15-42

-

761555

Substrates: -
Products: -

?

3-hydroxypropionaldehyde + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

670216

Substrates: -
Products: -

r

3-hydroxypropionaldehyde + NADH + H+

propane-1,3-diol + NAD+

Klebsiella pneumoniae

-

670216

Substrates: the enzyme is important in vivo for convertion of glycerol into propane-1,3-diol as second step after dehydration of glycerol by coenzyme B12-dependent glycerol dehydratase
Products: -

r

acetaldehyde + NADH + H+

ethanol + NAD+

Klebsiella pneumoniae

Q59477

740216

Substrates: -
Products: -

?

acetaldehyde + NADH + H+

ethanol + NAD+

Klebsiella pneumoniae J2B

Q59477

740216

Substrates: -
Products: -

?

ethanol + NAD+

acetaldehyde + NADH + H+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

ethanol + NAD+

acetaldehyde + NADH + H+

Levilactobacillus brevis 6239

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

ethanol + NAD+

NADH + ethanal

Citrobacter freundii

-

389494

Substrates: -
Products: -

r

ethanol + NAD+

NADH + ethanal

Levilactobacillus brevis

-

389498

Substrates: -
Products: -

?

formaldehyde + NADH + H+

methanol + NAD+

Klebsiella pneumoniae

Q59477

740216

Substrates: -
Products: -

?

formaldehyde + NADH + H+

methanol + NAD+

Klebsiella pneumoniae J2B

Q59477

740216

Substrates: -
Products: -

?

glycerol + NAD+

dihydroxyacetone + NADH + H+

Clostridium butyricum

-

760717

Substrates: 24.1% activity compared to propane-1,3-diol
Products: -

r

glycerol + NAD+

dihydroxyacetone + NADH + H+

Clostridium butyricum YJH-09

-

760717

Substrates: 24.1% activity compared to propane-1,3-diol
Products: -

r

glycerol + NAD+

dihydroxyacetone + NADH + H+

Levilactobacillus brevis

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

glycerol + NAD+

dihydroxyacetone + NADH + H+

Levilactobacillus brevis 6239

A0A0C1Q6R1

739886

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Citrobacter freundii

-

389494, 740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Citrobacter freundii DSM 30040

-

740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Clostridium butyricum

-

389496, 740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Clostridium butyricum E5

-

740214, 389496

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Clostridium pasteurianum

-

740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Clostridium perfringens

-

740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Klebsiella pneumoniae

-

740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Klebsiella pneumoniae DSM2026

-

740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Lentilactobacillus buchneri

-

389498, 740214

Substrates: -
Products: -

r

glycerol + NAD+

glyceraldehyde + NADH + H+

Levilactobacillus brevis

-

389498, 740214

Substrates: -
Products: -