BRENDA - Enzyme Database
show all sequences of 1.1.1.202

Key enzymes catalyzing glycerol to 1,3-propanediol

Jiang, W.; Wang, S.; Wang, Y.; Fang, B.; Biotechnol. Biofuels 9, 57 (2016)

Data extracted from this reference:

Application
Application
Commentary
Organism
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Citrobacter freundii
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Clostridium butyricum
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Clostridium pasteurianum
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Clostridium perfringens
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Klebsiella pneumoniae
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Lactobacillus brevis
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Lactobacillus buchneri
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Lactobacillus reuteri
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Pantoea agglomerans
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Thermotoga maritima
Cloned(Commentary)
Cloned (Commentary)
Organism
gene dhaT, part of the dha regulon, genetic structure, overview. Coexpressions of the PDOR and GDHt from gene dhaB in Klebsiella pneumoniae result in an increase of molar yield from 50.6-64.0% of 1,3-propanediol
Clostridium butyricum
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli
Citrobacter freundii
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli
Clostridium perfringens
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli
Thermotoga maritima
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Clostridium pasteurianum
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Klebsiella pneumoniae
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Lactobacillus brevis
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Lactobacillus buchneri
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Lactobacillus reuteri
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Pantoea agglomerans
Engineering
Protein Variants
Commentary
Organism
additional information
the PDOR isozyme activity increases 4.6times, when the yqhD gene is expressed in the Klebsiella pneumoniae mutant strains AK, which is a knockout mutant of the GDH and PDOR
Klebsiella pneumoniae
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates
Lactobacillus brevis
Ca2+
activates
Lactobacillus buchneri
Fe2+
required, activates
Citrobacter freundii
Fe2+
required, activates
Clostridium butyricum
Fe2+
required, activates
Clostridium pasteurianum
Fe2+
required, activates
Clostridium perfringens
Fe2+
required, activates
Klebsiella pneumoniae
Fe2+
required, activates
Lactobacillus brevis
Fe2+
required, activates
Lactobacillus buchneri
Fe2+
required, activates
Lactobacillus reuteri
Fe2+
required, activates
Thermotoga maritima
K+
activates
Lactobacillus reuteri
Li+
activates
Clostridium butyricum
Mg2+
activates
Lactobacillus brevis
Mg2+
activates
Lactobacillus buchneri
Mn2+
activates
Citrobacter freundii
Mn2+
activates
Clostridium butyricum
Mn2+
activates
Clostridium pasteurianum
Mn2+
activates
Clostridium perfringens
Mn2+
activates
Klebsiella pneumoniae
Mn2+
activates
Lactobacillus brevis
Mn2+
activates
Lactobacillus buchneri
Mn2+
activates
Lactobacillus reuteri
Mn2+
activates
Pantoea agglomerans
Mn2+
activates
Thermotoga maritima
additional information
the highest enzyme activity occurs with Mn2+, while the enzyme activity declines by 60-90% with other cations
Clostridium butyricum
additional information
the highest enzyme activity occurs with Mn2+, while the enzyme activity declines by 60-90% with other cations
Clostridium pasteurianum
Na+
activates
Clostridium butyricum
Na+
activates
Klebsiella pneumoniae
NH4+
activates
Klebsiella pneumoniae
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38500
-
-
Pantoea agglomerans
41500
-
-
Klebsiella pneumoniae
42000
-
x * 42000
Clostridium butyricum
42000
-
x * 42000
Klebsiella pneumoniae
43400
-
-
Citrobacter freundii
336000
-
-
Klebsiella pneumoniae
347000
-
-
Citrobacter freundii
350000
-
-
Lactobacillus brevis
355000
-
-
Pantoea agglomerans
384200
-
-
Clostridium butyricum
387000
-
-
Klebsiella pneumoniae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1,2-propylene glycol + NAD+
Klebsiella pneumoniae
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Pantoea agglomerans
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium pasteurianum
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Lactobacillus brevis
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium butyricum
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Citrobacter freundii
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Lactobacillus buchneri
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium perfringens
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Thermotoga maritima
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Lactobacillus reuteri
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium butyricum E5
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Citrobacter freundii DSM 30040
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Klebsiella pneumoniae DSM2026
-
? + NADH + H+
-
-
r
1,4-butanediol + NAD+
Klebsiella pneumoniae
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Pantoea agglomerans
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Clostridium pasteurianum
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Lactobacillus brevis
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Clostridium butyricum
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Citrobacter freundii
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Lactobacillus buchneri
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Clostridium perfringens
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Thermotoga maritima
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Lactobacillus reuteri
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Citrobacter freundii DSM 30040
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Klebsiella pneumoniae DSM2026
-
4-hydroxybutanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Klebsiella pneumoniae
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Pantoea agglomerans
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Clostridium pasteurianum
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Lactobacillus brevis
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Clostridium butyricum
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Citrobacter freundii
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Lactobacillus buchneri
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Clostridium perfringens
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Thermotoga maritima
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Lactobacillus reuteri
-
1-butanal + NADH + H+
-
-
r
1-propanol + NAD+
Klebsiella pneumoniae
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Pantoea agglomerans
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium pasteurianum
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Lactobacillus brevis
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium butyricum
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Citrobacter freundii
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Lactobacillus buchneri
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium perfringens
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Thermotoga maritima
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Lactobacillus reuteri
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium butyricum E5
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Citrobacter freundii DSM 30040
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Klebsiella pneumoniae DSM2026
-
propanal + NADH + H+
-
-
r
glycerol + NAD+
Klebsiella pneumoniae
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Pantoea agglomerans
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Clostridium pasteurianum
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Lactobacillus brevis
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Clostridium butyricum
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Citrobacter freundii
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Lactobacillus buchneri
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Clostridium perfringens
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Thermotoga maritima
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Lactobacillus reuteri
-
glyceraldehyde + NADH + H+
-
-
r
additional information
Clostridium pasteurianum
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
?
-
-
-
additional information
Clostridium butyricum
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
?
-
-
-
additional information
Clostridium butyricum E5
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
?
-
-
-
propane-1,3-diol + NAD+
Klebsiella pneumoniae
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Pantoea agglomerans
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium pasteurianum
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Lactobacillus brevis
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium butyricum
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Citrobacter freundii
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Lactobacillus buchneri
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium perfringens
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Thermotoga maritima
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Lactobacillus reuteri
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium butyricum E5
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Citrobacter freundii DSM 30040
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Klebsiella pneumoniae DSM2026
-
3-hydroxypropanal + NADH + H+
-
-
r
Organism
Organism
UniProt
Commentary
Textmining
Citrobacter freundii
-
-
-
Citrobacter freundii DSM 30040
-
-
-
Clostridium butyricum
-
-
-
Clostridium butyricum E5
-
-
-
Clostridium pasteurianum
-
-
-
Clostridium perfringens
-
-
-
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae DSM2026
-
-
-
Lactobacillus brevis
-
-
-
Lactobacillus buchneri
-
-
-
Lactobacillus reuteri
-
-
-
Pantoea agglomerans
-
-
-
Thermotoga maritima
-
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.42
-
pH and temperature not specified in the publication
Pantoea agglomerans
4.51
-
pH and temperature not specified in the publication
Clostridium butyricum
7.28
-
pH and temperature not specified in the publication
Lactobacillus brevis
9.85
-
pH and temperature not specified in the publication
Klebsiella pneumoniae
11
-
pH and temperature not specified in the publication
Citrobacter freundii
37
-
pH and temperature not specified in the publication
Klebsiella pneumoniae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1,2-propylene glycol + NAD+
-
740214
Klebsiella pneumoniae
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Pantoea agglomerans
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium pasteurianum
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Lactobacillus brevis
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium butyricum
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Citrobacter freundii
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Lactobacillus buchneri
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium perfringens
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Thermotoga maritima
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Lactobacillus reuteri
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium butyricum E5
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Citrobacter freundii DSM 30040
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
? + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Klebsiella pneumoniae
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Pantoea agglomerans
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Clostridium pasteurianum
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Lactobacillus brevis
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Clostridium butyricum
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Citrobacter freundii
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Lactobacillus buchneri
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Clostridium perfringens
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Thermotoga maritima
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Lactobacillus reuteri
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Citrobacter freundii DSM 30040
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
4-hydroxybutanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Klebsiella pneumoniae
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Pantoea agglomerans
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Clostridium pasteurianum
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Lactobacillus brevis
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Clostridium butyricum
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Citrobacter freundii
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Lactobacillus buchneri
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Clostridium perfringens
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Thermotoga maritima
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Lactobacillus reuteri
1-butanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Klebsiella pneumoniae
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Pantoea agglomerans
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium pasteurianum
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Lactobacillus brevis
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium butyricum
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Citrobacter freundii
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Lactobacillus buchneri
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium perfringens
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Thermotoga maritima
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Lactobacillus reuteri
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium butyricum E5
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Citrobacter freundii DSM 30040
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
propanal + NADH + H+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Klebsiella pneumoniae
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Pantoea agglomerans
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium pasteurianum
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Lactobacillus brevis
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium butyricum
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Citrobacter freundii
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Lactobacillus buchneri
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium perfringens
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Thermotoga maritima
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Lactobacillus reuteri
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium butyricum E5
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Citrobacter freundii DSM 30040
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Klebsiella pneumoniae DSM2026
propane-1,3-diol + NAD+
-
-
-
r
glycerol + NAD+
-
740214
Klebsiella pneumoniae
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Pantoea agglomerans
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Clostridium pasteurianum
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Lactobacillus brevis
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Clostridium butyricum
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Citrobacter freundii
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Lactobacillus buchneri
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Clostridium perfringens
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Thermotoga maritima
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Lactobacillus reuteri
glyceraldehyde + NADH + H+
-
-
-
r
additional information
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
740214
Clostridium pasteurianum
?
-
-
-
-
additional information
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
740214
Clostridium butyricum
?
-
-
-
-
additional information
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
740214
Clostridium butyricum E5
?
-
-
-
-
propane-1,3-diol + NAD+
-
740214
Klebsiella pneumoniae
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Pantoea agglomerans
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium pasteurianum
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Lactobacillus brevis
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium butyricum
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Citrobacter freundii
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Lactobacillus buchneri
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium perfringens
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Thermotoga maritima
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Lactobacillus reuteri
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium butyricum E5
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Citrobacter freundii DSM 30040
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
3-hydroxypropanal + NADH + H+
-
-
-
r
Subunits
Subunits
Commentary
Organism
oligomer
x * 43400
Citrobacter freundii
oligomer
x * 42000
Clostridium butyricum
oligomer
x * 41500; x * 42000
Klebsiella pneumoniae
oligomer
x * 41000-46000
Lactobacillus brevis
oligomer
x * 38500
Pantoea agglomerans
Synonyms
Synonyms
Commentary
Organism
1,3-propanediol-oxydoreductase
-
Citrobacter freundii
1,3-propanediol-oxydoreductase
-
Clostridium butyricum
1,3-propanediol-oxydoreductase
-
Clostridium pasteurianum
1,3-propanediol-oxydoreductase
-
Clostridium perfringens
1,3-propanediol-oxydoreductase
-
Klebsiella pneumoniae
1,3-propanediol-oxydoreductase
-
Lactobacillus brevis
1,3-propanediol-oxydoreductase
-
Lactobacillus buchneri
1,3-propanediol-oxydoreductase
-
Lactobacillus reuteri
1,3-propanediol-oxydoreductase
-
Pantoea agglomerans
1,3-propanediol-oxydoreductase
-
Thermotoga maritima
DhaT
-
Citrobacter freundii
DhaT
-
Clostridium butyricum
DhaT
-
Clostridium pasteurianum
DhaT
-
Clostridium perfringens
DhaT
-
Klebsiella pneumoniae
DhaT
-
Lactobacillus brevis
DhaT
-
Lactobacillus buchneri
DhaT
-
Lactobacillus reuteri
DhaT
-
Pantoea agglomerans
DhaT
-
Thermotoga maritima
PDOR
-
Citrobacter freundii
PDOR
-
Clostridium butyricum
PDOR
-
Clostridium pasteurianum
PDOR
-
Clostridium perfringens
PDOR
-
Klebsiella pneumoniae
PDOR
-
Lactobacillus brevis
PDOR
-
Lactobacillus buchneri
PDOR
-
Lactobacillus reuteri
PDOR
-
Pantoea agglomerans
PDOR
-
Thermotoga maritima
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
-
Klebsiella pneumoniae
37
-
-
Citrobacter freundii
37
-
-
Clostridium butyricum
37
-
-
Lactobacillus brevis
37
-
-
Pantoea agglomerans
55
-
-
Klebsiella pneumoniae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.6
-
aldehyde reduction
Clostridium butyricum
6.6
-
aldehyde reduction
Clostridium pasteurianum
6.6
-
aldehyde reduction
Lactobacillus brevis
6.6
-
aldehyde reduction
Lactobacillus buchneri
6.6
-
aldehyde reduction
Lactobacillus reuteri
7.7
-
-
Citrobacter freundii
7.8
-
-
Pantoea agglomerans
9
-
alcohol oxidation
Clostridium pasteurianum
9
-
alcohol oxidation
Lactobacillus buchneri
9
-
alcohol oxidation
Lactobacillus reuteri
9.1
-
alcohol oxidation
Clostridium butyricum
9.5
-
alcohol oxidation
Klebsiella pneumoniae
10
-
alcohol oxidation
Klebsiella pneumoniae
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Klebsiella pneumoniae
NAD+
-
Lactobacillus reuteri
NAD+
-
Thermotoga maritima
NAD+
-
Citrobacter freundii
NAD+
-
Clostridium butyricum
NAD+
-
Clostridium pasteurianum
NAD+
-
Clostridium perfringens
NAD+
-
Lactobacillus brevis
NAD+
-
Lactobacillus buchneri
NAD+
-
Pantoea agglomerans
NADH
-
Klebsiella pneumoniae
NADH
-
Lactobacillus reuteri
NADH
-
Clostridium butyricum
NADH
-
Citrobacter freundii
NADH
-
Lactobacillus brevis
NADH
-
Clostridium pasteurianum
NADH
-
Clostridium perfringens
NADH
-
Lactobacillus buchneri
NADH
-
Pantoea agglomerans
NADH
-
Thermotoga maritima
Application (protein specific)
Application
Commentary
Organism
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Citrobacter freundii
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Clostridium butyricum
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Clostridium pasteurianum
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Clostridium perfringens
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Klebsiella pneumoniae
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Lactobacillus brevis
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Lactobacillus buchneri
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Lactobacillus reuteri
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Pantoea agglomerans
synthesis
the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant
Thermotoga maritima
Cloned(Commentary) (protein specific)
Commentary
Organism
gene dhaT, part of the dha regulon, genetic structure, overview. Coexpressions of the PDOR and GDHt from gene dhaB in Klebsiella pneumoniae result in an increase of molar yield from 50.6-64.0% of 1,3-propanediol
Clostridium butyricum
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli
Citrobacter freundii
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli
Clostridium perfringens
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli
Thermotoga maritima
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Clostridium pasteurianum
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Klebsiella pneumoniae
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Lactobacillus brevis
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Lactobacillus buchneri
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Lactobacillus reuteri
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli
Pantoea agglomerans
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Klebsiella pneumoniae
NAD+
-
Lactobacillus reuteri
NAD+
-
Citrobacter freundii
NAD+
-
Clostridium butyricum
NAD+
-
Clostridium pasteurianum
NAD+
-
Clostridium perfringens
NAD+
-
Lactobacillus brevis
NAD+
-
Lactobacillus buchneri
NAD+
-
Pantoea agglomerans
NAD+
-
Thermotoga maritima
NADH
-
Klebsiella pneumoniae
NADH
-
Lactobacillus reuteri
NADH
-
Clostridium butyricum
NADH
-
Citrobacter freundii
NADH
-
Clostridium pasteurianum
NADH
-
Clostridium perfringens
NADH
-
Lactobacillus brevis
NADH
-
Lactobacillus buchneri
NADH
-
Pantoea agglomerans
NADH
-
Thermotoga maritima
Engineering (protein specific)
Protein Variants
Commentary
Organism
additional information
the PDOR isozyme activity increases 4.6times, when the yqhD gene is expressed in the Klebsiella pneumoniae mutant strains AK, which is a knockout mutant of the GDH and PDOR
Klebsiella pneumoniae
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates
Lactobacillus brevis
Ca2+
activates
Lactobacillus buchneri
Fe2+
required, activates
Citrobacter freundii
Fe2+
required, activates
Clostridium butyricum
Fe2+
required, activates
Clostridium pasteurianum
Fe2+
required, activates
Clostridium perfringens
Fe2+
required, activates
Klebsiella pneumoniae
Fe2+
required, activates
Lactobacillus brevis
Fe2+
required, activates
Lactobacillus buchneri
Fe2+
required, activates
Lactobacillus reuteri
Fe2+
required, activates
Thermotoga maritima
K+
activates
Lactobacillus reuteri
Li+
activates
Clostridium butyricum
Mg2+
activates
Lactobacillus brevis
Mg2+
activates
Lactobacillus buchneri
Mn2+
activates
Citrobacter freundii
Mn2+
activates
Clostridium butyricum
Mn2+
activates
Clostridium pasteurianum
Mn2+
activates
Clostridium perfringens
Mn2+
activates
Klebsiella pneumoniae
Mn2+
activates
Lactobacillus brevis
Mn2+
activates
Lactobacillus buchneri
Mn2+
activates
Lactobacillus reuteri
Mn2+
activates
Pantoea agglomerans
Mn2+
activates
Thermotoga maritima
additional information
the highest enzyme activity occurs with Mn2+, while the enzyme activity declines by 60-90% with other cations
Clostridium butyricum
additional information
the highest enzyme activity occurs with Mn2+, while the enzyme activity declines by 60-90% with other cations
Clostridium pasteurianum
Na+
activates
Clostridium butyricum
Na+
activates
Klebsiella pneumoniae
NH4+
activates
Klebsiella pneumoniae
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38500
-
-
Pantoea agglomerans
41500
-
-
Klebsiella pneumoniae
42000
-
x * 42000
Clostridium butyricum
42000
-
x * 42000
Klebsiella pneumoniae
43400
-
-
Citrobacter freundii
336000
-
-
Klebsiella pneumoniae
347000
-
-
Citrobacter freundii
350000
-
-
Lactobacillus brevis
355000
-
-
Pantoea agglomerans
384200
-
-
Clostridium butyricum
387000
-
-
Klebsiella pneumoniae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1,2-propylene glycol + NAD+
Klebsiella pneumoniae
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Pantoea agglomerans
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium pasteurianum
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Lactobacillus brevis
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium butyricum
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Citrobacter freundii
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Lactobacillus buchneri
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium perfringens
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Thermotoga maritima
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Lactobacillus reuteri
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Clostridium butyricum E5
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Citrobacter freundii DSM 30040
-
? + NADH + H+
-
-
r
1,2-propylene glycol + NAD+
Klebsiella pneumoniae DSM2026
-
? + NADH + H+
-
-
r
1,4-butanediol + NAD+
Klebsiella pneumoniae
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Pantoea agglomerans
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Clostridium pasteurianum
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Lactobacillus brevis
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Clostridium butyricum
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Citrobacter freundii
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Lactobacillus buchneri
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Clostridium perfringens
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Thermotoga maritima
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Lactobacillus reuteri
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Citrobacter freundii DSM 30040
-
4-hydroxybutanal + NADH + H+
-
-
r
1,4-butanediol + NAD+
Klebsiella pneumoniae DSM2026
-
4-hydroxybutanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Klebsiella pneumoniae
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Pantoea agglomerans
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Clostridium pasteurianum
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Lactobacillus brevis
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Clostridium butyricum
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Citrobacter freundii
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Lactobacillus buchneri
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Clostridium perfringens
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Thermotoga maritima
-
1-butanal + NADH + H+
-
-
r
1-butyl alcohol + NAD+
Lactobacillus reuteri
-
1-butanal + NADH + H+
-
-
r
1-propanol + NAD+
Klebsiella pneumoniae
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Pantoea agglomerans
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium pasteurianum
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Lactobacillus brevis
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium butyricum
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Citrobacter freundii
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Lactobacillus buchneri
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium perfringens
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Thermotoga maritima
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Lactobacillus reuteri
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Clostridium butyricum E5
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Citrobacter freundii DSM 30040
-
propanal + NADH + H+
-
-
r
1-propanol + NAD+
Klebsiella pneumoniae DSM2026
-
propanal + NADH + H+
-
-
r
glycerol + NAD+
Klebsiella pneumoniae
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Pantoea agglomerans
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Clostridium pasteurianum
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Lactobacillus brevis
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Clostridium butyricum
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Citrobacter freundii
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Lactobacillus buchneri
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Clostridium perfringens
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Thermotoga maritima
-
glyceraldehyde + NADH + H+
-
-
r
glycerol + NAD+
Lactobacillus reuteri
-
glyceraldehyde + NADH + H+
-
-
r
additional information
Clostridium pasteurianum
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
?
-
-
-
additional information
Clostridium butyricum
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
?
-
-
-
additional information
Clostridium butyricum E5
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
?
-
-
-
propane-1,3-diol + NAD+
Klebsiella pneumoniae
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Pantoea agglomerans
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium pasteurianum
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Lactobacillus brevis
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium butyricum
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Citrobacter freundii
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Lactobacillus buchneri
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium perfringens
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Thermotoga maritima
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Lactobacillus reuteri
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Clostridium butyricum E5
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Citrobacter freundii DSM 30040
-
3-hydroxypropanal + NADH + H+
-
-
r
propane-1,3-diol + NAD+
Klebsiella pneumoniae DSM2026
-
3-hydroxypropanal + NADH + H+
-
-
r
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.42
-
pH and temperature not specified in the publication
Pantoea agglomerans
4.51
-
pH and temperature not specified in the publication
Clostridium butyricum
7.28
-
pH and temperature not specified in the publication
Lactobacillus brevis
9.85
-
pH and temperature not specified in the publication
Klebsiella pneumoniae
11
-
pH and temperature not specified in the publication
Citrobacter freundii
37
-
pH and temperature not specified in the publication
Klebsiella pneumoniae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1,2-propylene glycol + NAD+
-
740214
Klebsiella pneumoniae
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Pantoea agglomerans
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium pasteurianum
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Lactobacillus brevis
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium butyricum
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Citrobacter freundii
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Lactobacillus buchneri
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium perfringens
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Thermotoga maritima
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Lactobacillus reuteri
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Clostridium butyricum E5
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Citrobacter freundii DSM 30040
? + NADH + H+
-
-
-
r
1,2-propylene glycol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
? + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Klebsiella pneumoniae
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Pantoea agglomerans
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Clostridium pasteurianum
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Lactobacillus brevis
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Clostridium butyricum
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Citrobacter freundii
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Lactobacillus buchneri
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Clostridium perfringens
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Thermotoga maritima
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Lactobacillus reuteri
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Citrobacter freundii DSM 30040
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
4-hydroxybutanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Klebsiella pneumoniae
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Pantoea agglomerans
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Clostridium pasteurianum
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Lactobacillus brevis
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Clostridium butyricum
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Citrobacter freundii
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Lactobacillus buchneri
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Clostridium perfringens
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Thermotoga maritima
1-butanal + NADH + H+
-
-
-
r
1-butyl alcohol + NAD+
-
740214
Lactobacillus reuteri
1-butanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Klebsiella pneumoniae
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Pantoea agglomerans
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium pasteurianum
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Lactobacillus brevis
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium butyricum
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Citrobacter freundii
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Lactobacillus buchneri
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium perfringens
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Thermotoga maritima
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Lactobacillus reuteri
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Clostridium butyricum E5
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Citrobacter freundii DSM 30040
propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
propanal + NADH + H+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Klebsiella pneumoniae
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Pantoea agglomerans
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium pasteurianum
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Lactobacillus brevis
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium butyricum
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Citrobacter freundii
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Lactobacillus buchneri
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium perfringens
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Thermotoga maritima
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Lactobacillus reuteri
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Clostridium butyricum E5
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Citrobacter freundii DSM 30040
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
-
740214
Klebsiella pneumoniae DSM2026
propane-1,3-diol + NAD+
-
-
-
r
glycerol + NAD+
-
740214
Klebsiella pneumoniae
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Pantoea agglomerans
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Clostridium pasteurianum
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Lactobacillus brevis
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Clostridium butyricum
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Citrobacter freundii
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Lactobacillus buchneri
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Clostridium perfringens
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Thermotoga maritima
glyceraldehyde + NADH + H+
-
-
-
r
glycerol + NAD+
-
740214
Lactobacillus reuteri
glyceraldehyde + NADH + H+
-
-
-
r
additional information
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
740214
Clostridium pasteurianum
?
-
-
-
-
additional information
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
740214
Clostridium butyricum
?
-
-
-
-
additional information
the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction
740214
Clostridium butyricum E5
?
-
-
-
-
propane-1,3-diol + NAD+
-
740214
Klebsiella pneumoniae
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Pantoea agglomerans
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium pasteurianum
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Lactobacillus brevis
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium butyricum
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Citrobacter freundii
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Lactobacillus buchneri
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium perfringens
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Thermotoga maritima
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Lactobacillus reuteri
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Clostridium butyricum E5
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Citrobacter freundii DSM 30040
3-hydroxypropanal + NADH + H+
-
-
-
r
propane-1,3-diol + NAD+
-
740214
Klebsiella pneumoniae DSM2026
3-hydroxypropanal + NADH + H+
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
oligomer
x * 43400
Citrobacter freundii
oligomer
x * 42000
Clostridium butyricum
oligomer
x * 41500; x * 42000
Klebsiella pneumoniae
oligomer
x * 41000-46000
Lactobacillus brevis
oligomer
x * 38500
Pantoea agglomerans
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
-
Klebsiella pneumoniae
37
-
-
Citrobacter freundii
37
-
-
Clostridium butyricum
37
-
-
Lactobacillus brevis
37
-
-
Pantoea agglomerans
55
-
-
Klebsiella pneumoniae
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.6
-
aldehyde reduction
Clostridium butyricum
6.6
-
aldehyde reduction
Clostridium pasteurianum
6.6
-
aldehyde reduction
Lactobacillus brevis
6.6
-
aldehyde reduction
Lactobacillus buchneri
6.6
-
aldehyde reduction
Lactobacillus reuteri
7.7
-
-
Citrobacter freundii
7.8
-
-
Pantoea agglomerans
9
-
alcohol oxidation
Clostridium pasteurianum
9
-
alcohol oxidation
Lactobacillus buchneri
9
-
alcohol oxidation
Lactobacillus reuteri
9.1
-
alcohol oxidation
Clostridium butyricum
9.5
-
alcohol oxidation
Klebsiella pneumoniae
10
-
alcohol oxidation
Klebsiella pneumoniae
General Information
General Information
Commentary
Organism
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Citrobacter freundii
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Clostridium butyricum
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Clostridium pasteurianum
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Clostridium perfringens
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Klebsiella pneumoniae
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Lactobacillus brevis
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Lactobacillus buchneri
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Lactobacillus reuteri
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Pantoea agglomerans
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Thermotoga maritima
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Citrobacter freundii
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Clostridium butyricum
malfunction
accumulation of 3-HPA can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Clostridium pasteurianum
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Clostridium perfringens
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Klebsiella pneumoniae
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Lactobacillus brevis
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Lactobacillus buchneri
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Lactobacillus reuteri
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Pantoea agglomerans
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Thermotoga maritima
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Citrobacter freundii
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Clostridium butyricum
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Clostridium pasteurianum
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Clostridium perfringens
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Klebsiella pneumoniae
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Lactobacillus brevis
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Lactobacillus buchneri
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Lactobacillus reuteri
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Pantoea agglomerans
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Thermotoga maritima
General Information (protein specific)
General Information
Commentary
Organism
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Citrobacter freundii
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Clostridium butyricum
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Clostridium pasteurianum
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Clostridium perfringens
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Klebsiella pneumoniae
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Lactobacillus brevis
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Lactobacillus buchneri
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Lactobacillus reuteri
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Pantoea agglomerans
evolution
PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase
Thermotoga maritima
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Citrobacter freundii
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Clostridium butyricum
malfunction
accumulation of 3-HPA can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Clostridium pasteurianum
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Clostridium perfringens
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Klebsiella pneumoniae
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Lactobacillus brevis
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Lactobacillus buchneri
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Lactobacillus reuteri
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Pantoea agglomerans
malfunction
accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol
Thermotoga maritima
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Citrobacter freundii
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Clostridium butyricum
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Clostridium pasteurianum
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Clostridium perfringens
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Klebsiella pneumoniae
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Lactobacillus brevis
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Lactobacillus buchneri
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Lactobacillus reuteri
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Pantoea agglomerans
metabolism
glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone
Thermotoga maritima
Other publictions for EC 1.1.1.202
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739886
Qi
Expression and characterizatio ...
Lactobacillus brevis, Lactobacillus brevis 6239
Appl. Biochem. Biotechnol.
179
959-972
2016
-
-
1
-
-
-
4
4
-
3
1
3
-
5
-
-
1
-
-
-
2
-
19
1
2
2
2
2
-
2
2
2
2
-
-
-
-
-
1
2
-
-
-
-
4
-
4
-
3
1
3
-
-
-
1
-
-
2
-
19
1
2
2
2
-
2
2
2
-
-
2
2
-
-
-
740214
Jiang
Key enzymes catalyzing glycero ...
Citrobacter freundii, Citrobacter freundii DSM 30040, Clostridium butyricum, Clostridium butyricum E5, Clostridium pasteurianum, Clostridium perfringens, Klebsiella pneumoniae, Klebsiella pneumoniae DSM2026, Lactobacillus brevis, Lactobacillus buchneri, Lactobacillus reuteri, Pantoea agglomerans, Thermotoga maritima
Biotechnol. Biofuels
9
57
2016
-
10
10
-
1
-
-
-
-
30
11
74
-
17
-
-
-
-
-
-
6
-
87
5
30
6
-
-
-
13
-
-
20
-
-
-
-
10
10
20
-
1
-
-
-
-
-
-
30
11
74
-
-
-
-
-
-
6
-
87
5
6
-
-
-
13
-
-
-
-
30
30
-
-
-
740216
Lama
-
Characterization of 1,3-propan ...
Klebsiella pneumoniae, Klebsiella pneumoniae J2B
Biotechnol. Bioprocess Eng.
20
971-979
2015
1
-
1
-
-
-
8
9
-
1
-
2
-
2
-
-
1
-
-
-
4
-
13
-
3
2
2
-
9
2
2
-
2
-
-
-
1
-
1
2
-
-
-
-
8
-
9
-
1
-
2
-
-
-
1
-
-
4
-
13
-
2
2
-
9
2
2
-
-
-
2
2
-
9
9
740927
Qi
-
Overexpression and characteriz ...
Citrobacter freundii
Key Eng. Mater.
636
121-124
2014
-
-
1
-
-
-
-
2
-
-
2
2
-
1
-
-
1
-
-
-
-
-
2
1
3
-
-
-
-
-
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
2
-
-
2
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
747304
Durgapal
Production of 1,3-propanediol ...
Klebsiella pneumoniae, Klebsiella pneumoniae J2B
Bioresour. Technol.
159
223-231
2014
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721395
Elleuche
Structural and biochemical cha ...
Oenococcus oeni, Oenococcus oeni ATCC BAA-1163
Appl. Microbiol. Biotechnol.
97
8963-8975
2013
-
-
1
1
-
-
1
4
-
1
3
-
-
6
-
-
-
-
-
-
1
-
6
1
2
1
-
1
-
2
-
1
3
-
1
-
-
-
1
3
1
-
-
-
1
-
4
-
1
3
-
-
-
-
-
-
-
1
-
6
1
1
-
1
-
2
-
1
1
-
-
-
-
4
4
724566
Oh
Efficient production of 1,3-pr ...
Klebsiella pneumoniae
Bioprocess Biosyst. Eng.
36
757-763
2013
-
1
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725951
Qi
Molecular cloning, co-expressi ...
Citrobacter freundii
Mol. Biotechnol.
54
469-474
2013
-
-
1
-
-
-
-
2
-
-
1
-
-
2
-
-
-
-
-
-
2
-
2
1
2
2
-
-
-
2
2
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
2
-
2
1
2
-
-
-
2
2
-
-
-
-
-
-
-
-
725880
Stevens
1,3-Propanediol dehydrogenases ...
Lactobacillus reuteri
Microb. Cell Fact.
10
61
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
695716
Ma
Construction of a Novel Expres ...
Klebsiella pneumoniae
Appl. Biochem. Biotechnol.
162
399-407
2010
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
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-
-
-
1
1
-
-
-
-
-
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-
-
-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710747
Jeyakanthan
Expression, purification and X ...
Aquifex aeolicus
Acta Crystallogr. Sect. F
66
184-186
2010
-
-
1
1
-
-
-
-
-
-
1
-
-
4
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710972
Zhuge
Expression of 1,3-propanediol ...
Escherichia coli, Klebsiella pneumoniae
Appl. Microbiol. Biotechnol.
87
2177-2184
2010
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712531
Ma
Relaxing the coenzyme specific ...
Klebsiella pneumoniae
J. Biotechnol.
146
173-178
2010
-
-
-
1
2
-
-
6
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
6
-
-
-
2
-
-
-
-
-
-
2
1
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
6
-
-
-
-
-
-
-
-
6
6
695764
Tang
Microbial conversion of glycer ...
Escherichia coli, Escherichia coli SYU 21132
Appl. Environ. Microbiol.
75
1628-1634
2009
1
1
1
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
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1
1
1
1
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-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695842
Seo
Elimination of by-product form ...
Klebsiella pneumoniae, Klebsiella pneumoniae Cu
Appl. Microbiol. Biotechnol.
84
527-534
2009
1
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695844
Seo
Identification and utilization ...
Escherichia coli, Klebsiella pneumoniae
Appl. Microbiol. Biotechnol.
85
659-666
2009
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
1
-
-
-
-
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Effects of over-expression of ...
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Marcal
1,3-Propanediol dehydrogenase ...
Klebsiella pneumoniae
J. Bacteriol.
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2009
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Zhao
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J. Chem. Technol. Biotechnol.
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2009
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684524
Nemeth
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Appl. Biochem. Biotechnol.
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Decrease of 3-hydroxypropional ...
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Hao
3-Hydroxypropionaldehyde guide ...
Klebsiella pneumoniae
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675901
Wang
Production of 1,3-propanediol ...
Klebsiella pneumoniae
Mol. Biotechnol.
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2007
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684171
Marcal
Crystallization and preliminar ...
Klebsiella pneumoniae
Acta Crystallogr. Sect. F
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667270
Gonzalez-Pajuelo
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Enhancement of 1,3-propanediol ...
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Fenghuan
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655107
Zheng
Cloning and sequence analysis ...
Klebsiella pneumoniae
Biotechnol. Lett.
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Schwarzenbacher
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Thermotoga maritima
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2003
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657406
Nemeth
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1,3-Propanediol oxidoreductase ...
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
World J. Microbiol. Biotechnol.
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2003
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Malaoui
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2000
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Abbad-Andaloussi
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1998
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Lactobacillus brevis, Lactobacillus buchneri
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389489
Heyndrickx
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Talarico
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Abeles
beta-Hydroxypropionaldehyde, a ...
Klebsiella pneumoniae
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41
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