2.4.1.360: 2-hydroxyflavanone C-glucosyltransferase
This is an abbreviated version!
For detailed information about 2-hydroxyflavanone C-glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.360
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2.4.1.360
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c-glucosylation
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flavonoid
-
c-glycosyltransferases
-
sativa
-
o-glucosyltransferase
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dehydratase
-
o-glycosylated
-
planta
-
c-glycosylflavones
-
flavone
-
cereals
-
phloretin
-
synthesis
-
dibenzoylmethane
- 2.4.1.360
-
c-glucosylation
- flavonoid
-
c-glycosyltransferases
- sativa
-
o-glucosyltransferase
- dehydratase
-
o-glycosylated
-
planta
-
c-glycosylflavones
- flavone
-
cereals
- phloretin
- synthesis
- dibenzoylmethane
Reaction
Synonyms
CuCGT, FcCGT, OsCGT, UDP-glucose:2-hydroxyflavanone-6(or8)-C-glucosyltransferase, UGT708C1, UGT708C2
ECTree
2.4.1.360 2-hydroxyflavanone C-glucosyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.360 - 2-hydroxyflavanone C-glucosyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 UDP-alpha-D-glucose + 2 2,5,7-trihydroxyflavanone
2 UDP + 6-(beta-D-glucopyranosyl)-2,5,7-trihydroxyflavanone + 8-(beta-D-glucopyranosyl)-2,5,7-trihydroxyflavanone
meta-stable 2-hydroxyflavanones exist in an equilibirum with their open-form dibenzoylmethane tautomers which probably are the actual glucosyl-acceptors
-
-
?
2 UDP-alpha-D-glucose + 2 2-hydroxyeriodictyol
2 UDP + 6-(beta-D-glucopyranosyl)-2-hydroxyeriodictyol + 8-(beta-D-glucopyranosyl)-2-hydroxyeriodictyol
meta-stable 2-hydroxyflavanones exist in an equilibirum with their open-form dibenzoylmethane tautomers which probably are the actual glucosyl-acceptors
-
-
?
2 UDP-alpha-D-glucose + 2 2-hydroxynaringenin
2 UDP + 6-(beta-D-glucopyranosyl)-2-hydroxynaringenin + 8-(beta-D-glucopyranosyl)-2-hydroxynaringenin
2 UDP-alpha-D-glucose + 2-hydroxyeriodictyol
2 UDP + ?
-
-
-
?
2 UDP-alpha-D-glucose + 2-hydroxynaringenin
2 UDP + 6,8-di-(beta-D-glucopyranosyl)-2-hydroxynaringenin
2 UDP-alpha-D-glucose + 2-hydroxypinocembrin
2 UDP + ?
-
-
-
?
2 UDP-alpha-D-glucose + 2-phenyl-2',4',6'-trihydroxyacetophenone
2 UDP + ?
-
-
-
?
2 UDP-alpha-D-glucose + phloretin
2 UDP + ?
-
-
-
?
UDP-alpha-D-glucose + 2',4',6'-trihydroxydihydrochalcone
UDP + ?
-
-
-
?
UDP-alpha-D-glucose + 2,4,6-trihydroxybenzophenone
UDP + ?
-
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + affinetin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 40% affinetin and 27% isoaffinetin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + isoaffinetin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 40% affinetin and 27% isoaffinetin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(3-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 14% 8-C-glucoside and 25% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + isopyrenin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 69% pyrenin and 21% isopyrenin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one + H+
UDP + pyrenin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 69% pyrenin and 21% isopyrenin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + isoscoparin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 41% scoparin and 53% isoscoparin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + scoparin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 41% scoparin and 53% isoscoparin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + cytisocide + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 44% cytisocide and 52% isocytisocide
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
UDP + isocytisocide + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 44% cytisocide and 52% isocytisocide
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
UDP + 6-C-glucosylchrysin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 33% 8-C-glucosylchrysin and 47% 6-C-glucosylchrysin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
UDP + 8-C-glucosylchrysin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 33% 8-C-glucosylchrysin and 47% 6-C-glucosylchrysin
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
-
-
-
-
?
UDP-alpha-D-glucose + 2,5,7-trihydroxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 34% 8-C-glucoside and 42% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2-(3,5-dihydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 47% 8-C-glucoside and 43% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2-(3-fluoro-4-hydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
UDP-alpha-D-glucose + 2-(4-ethoxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 34% 8-C-glucoside and 38% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2-(4-fluorophenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 45% 8-C-glucoside and 47% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2-hydroxyeriodictyol
UDP + isoorientin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 43% orientin and 56% isoorientin
-
-
?
UDP-alpha-D-glucose + 2-hydroxyeriodictyol
UDP + orientin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 43% orientin and 56% isoorientin
-
-
?
UDP-alpha-D-glucose + 2-hydroxynaringenin
UDP + 6-(beta-D-glucopyranosyl)-2-hydroxynaringenin
-
-
-
?
UDP-alpha-D-glucose + 2-hydroxynaringenin
UDP + 8-(beta-D-glucopyranosyl)-2-hydroxynaringenin
-
-
-
?
UDP-alpha-D-glucose + 2-hydroxynaringenin
UDP + ?
-
-
-
?
UDP-alpha-D-glucose + a 2'-hydroxy-beta-oxodihydrochalcone
UDP + a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone
-
-
-
?
UDP-alpha-D-glucose + benzyl 2,4,6-trihydroxybenzoate
UDP + ?
-
-
-
?
2 UDP-alpha-D-glucose + 2 2-hydroxynaringenin
2 UDP + 6-(beta-D-glucopyranosyl)-2-hydroxynaringenin + 8-(beta-D-glucopyranosyl)-2-hydroxynaringenin
the meta-stable 2-hydroxynaringenin exists in an equilibirum with its open-form 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione which is the actual glucosyl-acceptor
-
-
?
2 UDP-alpha-D-glucose + 2 2-hydroxynaringenin
2 UDP + 6-(beta-D-glucopyranosyl)-2-hydroxynaringenin + 8-(beta-D-glucopyranosyl)-2-hydroxynaringenin
the meta-stable 2-hydroxynaringenin exists in an equilibirum with its open-form 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione which is the actual glucosyl-acceptor
-
-
?
2 UDP-alpha-D-glucose + 2-hydroxynaringenin
2 UDP + 6,8-di-(beta-D-glucopyranosyl)-2-hydroxynaringenin
-
-
-
-
?
2 UDP-alpha-D-glucose + 2-hydroxynaringenin
2 UDP + 6,8-di-(beta-D-glucopyranosyl)-2-hydroxynaringenin
-
-
-
-
?
2 UDP-alpha-D-glucose + 2-hydroxynaringenin
2 UDP + 6,8-di-(beta-D-glucopyranosyl)-2-hydroxynaringenin
-
-
-
?
2 UDP-alpha-D-glucose + phloretin
2 UDP + 3',5'-di-(beta-D-glucopyranosyl)phloretin
-
-
-
-
?
2 UDP-alpha-D-glucose + phloretin
2 UDP + 3',5'-di-(beta-D-glucopyranosyl)phloretin
-
-
-
-
?
UDP-alpha-D-galactose + 2-hydroxypinocembrin
UDP + ?
-
low activity with sugar donor UDP-alpha-D-galactose
-
-
?
UDP-alpha-D-galactose + 2-hydroxypinocembrin
UDP + ?
-
low activity with sugar donor UDP-alpha-D-galactose
-
-
?
UDP-alpha-D-glucose + 2-(3-fluoro-4-hydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 17% 8-C-glucoside and 27% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2-(3-fluoro-4-hydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
UDP + ?
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 42% 8-C-glucoside and 56% 6-C-glucoside
-
-
?
UDP-alpha-D-glucose + 2-hydroxynaringenin
UDP + isovitexin + H2O
-
-
-
-
?
UDP-alpha-D-glucose + 2-hydroxynaringenin
UDP + isovitexin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 44% vitexin and 53% isovitexin
-
-
?
UDP-alpha-D-glucose + 2-hydroxynaringenin
UDP + vitexin + H2O
the enzyme is specific for its sugar donors. It shows no activity with UDP-glucuronic acid, UDP-galactose, UDP-arabinose, or UDP-N-acetylglucosamine. Products: 44% vitexin and 53% isovitexin
-
-
?
UDP-alpha-D-glucose + 2-phenyl-2',4',6'-trihydroxyacetophenone
UDP + ?
-
-
-
-
?
UDP-alpha-D-glucose + 2-phenyl-2',4',6'-trihydroxyacetophenone
UDP + ?
-
-
-
-
?
UDP-alpha-D-xylose + 6-beta-D-glucopyranosyl-2-hydroxynaringenin
UDP + ?
-
-
-
-
?
UDP-alpha-D-xylose + 6-beta-D-glucopyranosyl-2-hydroxynaringenin
UDP + ?
-
-
-
-
?
additional information
?
-
-
no activity with naringenin, apigenin, quercetin, isoliquiritigenin, propyl gallate, and 2',4'dihydroxyacetophenone suggesting that 2',4',6'-trihydroxyacetophenone-like structures are necessary for substrates to be acceptable. Very low activity with phloridzin
-
-
?
additional information
?
-
-
no activity with naringenin, apigenin, quercetin, isoliquiritigenin, propyl gallate, and 2',4'dihydroxyacetophenone suggesting that 2',4',6'-trihydroxyacetophenone-like structures are necessary for substrates to be acceptable. Very low activity with phloridzin
-
-
?
additional information
?
-
no activity with quercetin, luteorin, apigenin
-
-
?
additional information
?
-
no activity with quercetin, luteorin, apigenin
-
-
?
additional information
?
-
-
no activity with 2,5-dihydroxyflavanone or 2,4-dihydroxydibenzoylmethane. The enzyme also transfered the sugar moiety from UDP-Gal and UDP-Xyl to the aglycon by forming a C-glycosidic linkage, but not from UDP-GlcA
-
-
?
