1.14.14.80: long-chain fatty acid omega-monooxygenase
This is an abbreviated version!
For detailed information about long-chain fatty acid omega-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.80
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1.14.14.80
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peroxisome
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arachidonic
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20-hete
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lauric
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20-hydroxyeicosatetraenoic
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clofibrate
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omega-hydroxylase
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cyp2c11
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omega-hydroxylation
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proliferators
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cyp3a1
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pparalpha
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epoxyeicosatrienoic
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ethoxyresorufin
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cyp2j3
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ja-ile
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sporopollenin
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interlobar
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cyp94b3
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clofibrate-inducible
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omega-1
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ciprofibrate
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medicine
- 1.14.14.80
- peroxisome
-
arachidonic
- 20-hete
-
lauric
-
20-hydroxyeicosatetraenoic
- clofibrate
-
omega-hydroxylase
- cyp2c11
-
omega-hydroxylation
- proliferators
- cyp3a1
- pparalpha
-
epoxyeicosatrienoic
-
ethoxyresorufin
- cyp2j3
-
ja-ile
-
sporopollenin
-
interlobar
- cyp94b3
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clofibrate-inducible
- omega-1
- ciprofibrate
- medicine
Reaction
Synonyms
At1g69500, At2g27690, CYP4A, CYP4A1, CYP4A11, CYP4A14, CYP4A2, CYP4A3, CYP4A8, CYP4V2, CYP52-E3, CYP52-M1, CYP52-N1, CYP52E3, CYP52M1, CYP52N1, CYP704B1, CYP86A, CYP86A1, CYP86A33, CYP94C1, cytochrome P450 4A11, cytochrome P450 704B1, cytochrome P450 86A1, EC 1.14.13.205, Fatty acid omega-hydroxylase, Lauric acid omega-hydroxylase, omega-hydroxylase, P450 4A11
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General Information
General Information on EC 1.14.14.80 - long-chain fatty acid omega-monooxygenase
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evolution
metabolism
physiological function
the enzyme is a member of the cytochrome P450 monooxygenase CYP52 gene family
evolution
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the enzyme is a member of the cytochrome P450 monooxygenase CYP52 gene family
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CYP52M1 is involved in the biosynthesis of sophorolipid
metabolism
enzyme CYP52E3 might be involved in alkane metabolism in Starmerella bombicola but downstream of the initial oxidation steps
metabolism
enzyme CYP52N1 might be involved in alkane metabolism in Starmerella bombicola but downstream of the initial oxidation steps
metabolism
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CYP52M1 is involved in the biosynthesis of sophorolipid
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metabolism
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enzyme CYP52E3 might be involved in alkane metabolism in Starmerella bombicola but downstream of the initial oxidation steps
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metabolism
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enzyme CYP52N1 might be involved in alkane metabolism in Starmerella bombicola but downstream of the initial oxidation steps
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defective omega-oxidation of ocular fatty acids/lipids secondary to mutations in the CYP4V2 gene may be a plausible mechanism underlying Bietti's crystalline dystrophy
physiological function
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in male ddY mice, activity of lauric acid omega-hydroxylase is significantly higher than in female mice. The activity is the same in immature male and female mice, but is differentiated in the sexually mature state. In male ddY mice, orchiectomy causes a dramatic decrease in hepatic lauric acid omega-hydroxylase activity and the activity is restored by testosterone treatment. In female mice, ovariectomy and estradiol treatment have no effect on the activity, but testosterone treatment causes an increase in the activity
physiological function
isoform CYP52M1 is clearly upregulated during sophorolipid synthesis and very likely takes part in sophorolipid formation
physiological function
isoform CYP52M1 is involved in the biosynthesis of sophorolipid
physiological function
mutations in CYP704B1 result in impaired pollen walls that lack a normal exine layer and exhibit a characteristic striped surface, termed zebra phenotyp. Mutations in three genes, CYP704B1, CYP703A2, and another exine gene, MALE STERILITY2 result in pollen with remarkably similar zebra phenotypes, distinct from those of other known exine mutants. The double and triple mutant combinations do not result in the appearance of novel phenotypes or enhancement of single mutant phenotypes
physiological function
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omega-hydroxylated eicosatrienoic acids may serve as endogenous peroxisome proliferator-activated receptor alpha ligands. P450 arachidonic acid monooxygenases such as CYP2C epoxygenase and CYP4A omega-hydroxylase participate in ciprofibrate-induced peroxisomal proliferation and the activation of peroxisome proliferator-activated receptor alpha downstream targets
physiological function
gene CYP86A33 complements the Arabidopsis thaliana CYP86A1 mutant, horst-1
physiological function
hepatic CYP4A14 expression is up-regulated in three murine models of nonalcoholic fatty liver disease. Overexpression of CYP4A14 in the livers of C57BL/6 mice results in a fatty liver phenotype with a significant increase in hepatic fatty acid translocase (FAT/CD36) expression