Literature summary for 1.14.14.80 extracted from

Zhang, X.; Li, S.; Zhou, Y.; Su, W.; Ruan, X.; Wang, B.; Zheng, F.; Warner, M.; Gustafsson, J.; Guan, Y.
Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis (2017), Proc. Natl. Acad. Sci. USA, 114, 3181-3185 .

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Application

Application	Comment	Organism
medicine	hepatic CYP4A14 expression is up-regulated in three murine models of nonalcoholic fatty liver disease. Overexpression of CYP4A14 in the livers of C57BL/6 mice results in a fatty liver phenotype with a significant increase in hepatic fatty acid translocase (FAT/CD36) expression. CYP4A14 gene-deficient mice fed a high-fat diet or a methionine and choline-deficient diet exhibit attenuated liver lipid accumulation and reduced hepatic FAT/CD36 expression. Hepatic inflammation and fibrosis is markedly ameliorated in methionine and choline-deficient diet-fed CYP4A14-deficient mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O35728	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CYP4A14	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	hepatic CYP4A14 expression is up-regulated in three murine models of nonalcoholic fatty liver disease. Overexpression of CYP4A14 in the livers of C57BL/6 mice results in a fatty liver phenotype with a significant increase in hepatic fatty acid translocase (FAT/CD36) expression	Mus musculus

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Release 2023.1 (January 2023)