EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
4.1.99.13 | (6-4)DNA photolyase |
brain |
- |
747608 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
brain |
- |
489573, 489574, 489581, 735875 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
brain |
adult and fetal |
658735 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
brain |
embryonic, postnatal, and adult brains |
723023 |
2.6.1.40 | (R)-3-amino-2-methylpropionate-pyruvate transaminase |
brain |
distributed throughout the brain, with high expression in the retrosplenial cortex and in hippocampal neurons |
737947 |
1.1.5.13 | (S)-2-hydroxyglutarate dehydrogenase |
brain |
- |
755232 |
2.6.1.22 | (S)-3-amino-2-methylpropionate transaminase |
brain |
- |
636964 |
2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase |
brain |
- |
671597, 705206, 735714, 756108 |
2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase |
brain |
analysis of enzyme mRNA expression, transcript of approximately 2 kb length dominant |
487202 |
2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase |
brain |
cDNA library |
685339 |
2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase |
brain |
highest expression |
735599 |
2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase |
brain |
mAGPAT1, mAGPAT2, mAGPAT3, mAGPAT2 is undetectable, mAGPAT4 is expressed at high levels, mAGPAT5 expressed at high levels |
657854 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
brain |
- |
-, 486620, 486621, 486624, 486645, 657761, 659434, 674602, 701626, 704427, 704461, 706492, 756102, 758401 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
brain |
cortex |
486627 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
brain |
low expression level |
676806 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
brain |
predominantly, high expression level of LPEAT2, expression pattern analysis, overview. mLPEAT2 is expressed in all regions, with a comparatively high expression in the cortex |
755989 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
- |
650326, 653707, 669295, 670952, 80941, 80943, 80957 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
expression of PAFAH2 mRNA |
693526 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
fetal |
650505 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
isoform Ib |
653704 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
isozyme Ib |
653695 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
neonatal and adult, isozyme I |
651794 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
brain |
robust expression of PLA2G7 mRNA |
693526 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
brain |
- |
704418 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
brain |
- |
641769, 641770, 641771, 641786, 641798, 641802, 641806, 641810, 641812, 673232, 676179 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
brain |
myelin |
641792 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
brain |
the type IIalpha enzyme is concentrated both at the synapse and in the region of the Golgi complex in neuronal perikarya |
641817 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
brain |
- |
641771, 641822, 641823, 641824, 641829, 641830, 641833, 641835, 641849, 641852, 660641, 660965, 661660, 673332, 676808, 723653, 759416 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
brain |
in situ hybridisation of phosphatidylinositol 4-phosphate 5-kinase Igamma_v6 splice variant, which is not a major brain variant |
721497 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
brain |
moderate expression of PIP5KIbeta, low expression of PIP5KIalpha |
641842 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
brain |
phosphatidylinositol 4-phosphate 5-kinase Igamma_v6 is not a major brain variant |
721497 |
2.7.1.149 | 1-phosphatidylinositol-5-phosphate 4-kinase |
brain |
- |
393080, 738389 |
2.7.1.149 | 1-phosphatidylinositol-5-phosphate 4-kinase |
brain |
high mRNA expression |
684375 |
2.7.1.149 | 1-phosphatidylinositol-5-phosphate 4-kinase |
brain |
isoform PI5P4Kalpha is expressed in adulthood, whereas isoform PI5P4Kbeta is expressed early in development |
759554 |
1.5.1.21 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) |
brain |
- |
741580, 743355 |
1.5.1.21 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) |
brain |
especially in frontal and temporal cortex, the level of L-pipecolate is highest in the cerebellum |
741580 |
1.5.1.21 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) |
brain |
especially in frontal and temporal cortex, with the striatum having the maximal specific activity. Both the level of L-pipecolate and P2C/Pyr2C reductase-specific activity differed considerably among the different brain regions |
741580 |
1.5.1.1 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] |
brain |
- |
392038, 743353, 743355 |
1.5.1.1 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] |
brain |
high enzyme activity |
741580 |
1.5.1.1 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] |
brain |
prosencephalic region |
392037 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
brain |
8% mRNA expression of Rdh5 compared to liver |
690797 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
brain |
low activity |
692700 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
brain |
- |
654196, 688527, 711800, 740146, 740917, 760680, 760682, 760868, 762011 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
brain |
low level of expression, low acitivity |
693886 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
brain |
weak expression |
693886 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
brain |
11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone |
654196 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
brain |
11HSD1 is highly expressed in various brain structures, including the hippocampus |
743428 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
brain |
almost no expression and activity |
695148 |
1.3.1.48 | 13,14-dehydro-15-oxoprostaglandin 13-reductase |
brain |
- |
390826 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
brain |
- |
285912, 285930, 699476 |
1.1.1.197 | 15-hydroxyprostaglandin dehydrogenase (NADP+) |
brain |
- |
347830, 347835 |
1.1.1.196 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) |
brain |
- |
347824, 347825, 347826 |
1.14.14.32 | 17alpha-hydroxyprogesterone deacetylase |
brain |
- |
-, 705402, 715984, 734569 |
1.14.14.32 | 17alpha-hydroxyprogesterone deacetylase |
brain |
predominantly present |
703775 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
- |
656654, 688956, 740849 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
fetal, very low expression of isozyme AKR1B15.2 |
740743 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
HSD17B4 mRNA and activity are detectable in the early developing and adult brain |
711609 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
brain |
HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development. Females have significantly higher levels of HSD17B4 mRNA in auditory (caudomedial nidopallium) and visual (hyperpalliumapicale)regions than does males at day 25 |
740245 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
- |
-, 135380, 135381, 135384, 135385, 135386, 135388, 135389, 135390, 135391, 135392, 135399, 135400, 135401, 135402, 135404, 135407, 135409, 135411, 135418, 135419, 135422, 135424, 669848, 708596, 713118, 729185, 729954, 730238, 730475, 749958, 751698 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
amoeboid microglial cells in the postnatal rat brain |
-, 730239 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
CNP is associated with tubulin from brain |
653684 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
CNPase expression pattern of brain tissues in hypothyroid and control rats from post-natal days 5 to 90, hypothyroidism impairs transiently the CNPase gene expression, effect on oligodendrocyte differentiation and myelination |
651539 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
developing brain |
682134 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
embryonic brain |
670268 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
of adult |
668237 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
subventricular zone rostral extension, CNPase expression pattern during development from postnatal day 3 to 60 |
652982 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
there is little CNP2 in the forebrain postsynaptic density fraction, CNP1 is the major isoform in the neural and non-neural rat tissues, with the exception of myelinating cells in the adult brain, in which both isoforms are highly expressed, CNP2 is barely detectable in embryonic brain |
653229 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
two enzyme isoforms in chicken, just one isoform in bullfrog |
135421 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
brain |
white matter |
135425 |
2.7.7.84 | 2'-5' oligoadenylate synthase |
brain |
in the brain, only Oas1a, Oas1b, and Oas1g are expressed in the mice stimulated with poly I:C |
-, 761241 |
2.7.1.76 | 2'-deoxyadenosine kinase |
brain |
low activity |
641099 |
2.4.99.20 | 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase |
brain |
- |
724210 |
2.6.1.8 | 2,5-diaminovalerate transaminase |
brain |
- |
637811 |
2.3.1.62 | 2-acylglycerophosphocholine O-acyltransferase |
brain |
- |
486618 |
2.6.1.39 | 2-aminoadipate transaminase |
brain |
- |
639985, 703133, 721926 |
2.2.1.5 | 2-hydroxy-3-oxoadipate synthase |
brain |
- |
395924, 395928 |
3.6.1.56 | 2-hydroxy-dATP diphosphatase |
brain |
a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers |
716889 |
3.6.1.56 | 2-hydroxy-dATP diphosphatase |
brain |
oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction |
716299 |
4.1.2.63 | 2-hydroxyacyl-CoA lyase |
brain |
- |
760638 |
3.1.3.106 | 2-lysophosphatidate phosphatase |
brain |
- |
752696 |
1.1.1.172 | 2-oxoadipate reductase |
brain |
- |
286113 |
4.1.1.71 | 2-oxoglutarate decarboxylase |
brain |
- |
349037 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
brain |
- |
349034, 349035, 349037, 654854, 655234, 656591, 671961, 673654, 675552, 676088, 676319, 685378, 689950, 762740 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
brain |
diminished activities in regions with severe pathology, as well as in areas of minimal pathology, activity declines with the severity of disease |
676088 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
brain |
endothelial cells have about six times higher activity than do brain microglial cells or neurons |
349038 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
brain |
forebrain |
349036 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
brain |
neurons that appear slectively vulnerable in human temporal cortex in Alzheimer's disease are enriched in the 2-oxoglutarate dehydrogenase complex |
349042 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
brain |
postnatal increase of activity |
349007 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
- |
763094 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
20alpha-HSD mRNA highly expressed |
285997 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
analysis of 3alpha-HSOR mRNA distribution in the mouse brain by in situ hybridization has shown that this enzyme is co-localized with 5alpha-R type 1 in neurons of the cerebral cortex, hippocampus, olfactory bulb, amygdala and thalamus. And 3alpha-HSOR immunoreactivity is largely distributed in both white and gray matters |
763094 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
brain |
low expression rate of AKR1C23 |
669908 |
1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase |
brain |
- |
659660 |
3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase |
brain |
- |
728931, 750366 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
brain |
- |
667366, 677917, 678086, 678545, 684954, 685021, 687488, 689817, 690858, 691859, 750479 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
brain |
and skeletal muscle, predominant expression |
678086 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
brain |
high activity |
685021 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
brain |
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order |
689816 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
brain |
in the brain, PDE4D11 expression levels increase in the cerebellum, but decrease in the hippocampus with progressive age |
691716 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
brain |
isoform PDE4B5 is brain-specific |
681580 |