Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3',5-triiodothyronine | - |
Gallus gallus | |
indomethacin | - |
Canis lupus familiaris | |
indomethacin | - |
Gallus gallus | |
indomethacin | - |
Homo sapiens | |
indomethacin | - |
Platyrrhini | |
indomethacin | - |
Sus scrofa | |
additional information | not inhibited by L-thyronine and NADH | Gallus gallus | |
additional information | - |
Homo sapiens | |
additional information | not inhibited by thyroid hormones and NADPH | Platyrrhini | |
NADH | - |
Gallus gallus | |
NADH | - |
Homo sapiens | |
NADH | - |
Sus scrofa | |
NADPH | - |
Gallus gallus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Sus scrofa | |
Tetraiodothyroacetic acid | - |
Gallus gallus | |
thyroxine | - |
Canis lupus familiaris | |
thyroxine | - |
Gallus gallus | |
thyroxine | - |
Homo sapiens | |
thyroxine | - |
Platyrrhini | |
thyroxine | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
prostaglandin E2 | - |
Gallus gallus | |
0.025 | - |
prostaglandin F2alpha | - |
Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Platyrrhini | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Gallus gallus |
partial | Platyrrhini |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Platyrrhini | - |
erythrocyte | - |
Platyrrhini | - |
heart | - |
Gallus gallus | - |
heart | - |
Canis lupus familiaris | - |
heart | - |
Platyrrhini | - |
kidney | - |
Gallus gallus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Canis lupus familiaris | - |
kidney | - |
Platyrrhini | - |
liver | - |
Platyrrhini | - |
lung | - |
Homo sapiens | - |
lung | - |
Sus scrofa | - |
lung | - |
Platyrrhini | - |
spleen | - |
Gallus gallus | - |
spleen | - |
Homo sapiens | - |
spleen | - |
Sus scrofa | - |
spleen | - |
Canis lupus familiaris | - |
spleen | - |
Platyrrhini | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.025 | - |
enzyme from heart, substrate prostaglandin E2 | Gallus gallus |
0.136 | - |
enzyme from brain, substrate prostaglandin E2 | Platyrrhini |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | - |
Homo sapiens | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | - |
Sus scrofa | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | - |
Canis lupus familiaris | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | NAD+ is much more effective than NADP+ | Gallus gallus | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | NADP+ is more effective than NAD+ | Platyrrhini | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
prostaglandin E2 + NAD+ | - |
Gallus gallus | 15-oxoprostaglandin E2 + NADH + H+ | - |
r | |
prostaglandin F2alpha + NAD+ | - |
Homo sapiens | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? | |
prostaglandin F2alpha + NAD+ | - |
Sus scrofa | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? | |
prostaglandin F2alpha + NAD+ | - |
Canis lupus familiaris | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? | |
prostaglandin F2alpha + NAD+ | NAD+ is much more effective than NADP+ | Gallus gallus | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? | |
prostaglandin F2alpha + NAD+ | NADP+ is more effective than NAD+ | Platyrrhini | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | 8.5 | - |
Gallus gallus |
7.2 | 8.5 | - |
Platyrrhini |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Sus scrofa | |
NAD+ | - |
Canis lupus familiaris | |
NAD+ | much more effective than NADP+ | Gallus gallus | |
NAD+ | NADP+ is more effective | Platyrrhini | |
NADP+ | more efficient than NAD+ | Platyrrhini |