Information on EC 3.1.3.7 - 3'(2'),5'-bisphosphate nucleotidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.1.3.7
-
RECOMMENDED NAME
GeneOntology No.
3'(2'),5'-bisphosphate nucleotidase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
Microbial metabolism in diverse environments
-
Sulfur metabolism
-
SYSTEMATIC NAME
IUBMB Comments
adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase
Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3'(2'),5'-bisphosphate nucleotidase
Q38945
-
3'(2'),5'-bisphosphate nucleotidase
Q42546
gene FIERY1, dual enzymatic activity: inositol polyphosphate-1-phosphatase
3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase
-
-
-
-
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
-
-
-
-
3'(2')-phosphoadenosine 5-phosphate phosphatase
O95861
-
3'-PAPase
-
-
3'-phosphoadenosine 5'-phosphate 3'-phosphatase
-
-
3'-phosphoadenosine 5'-phosphate phosphatase
-
-
3'-phosphoadenosine-5'-phosphatase
P65163
-
3'-phosphoadenylylsulfate 3'-phosphatase
-
-
-
-
3(2),5-bisphosphate nucleotidase
Q38945
-
3(2),5-bisphosphate nucleotidase
-
-
3-phosphoadenosine 5-phosphate phosphatase
-
-
3-phosphoadenosine-5-phosphatase
Q3LS17
-
3-phosphoadenosine-5-phosphatase
-
-
3-phosphoesterase
Q94G04
-
adenosine-3',5'-bisphosphate 3'-phosphohydrolase
-
-
-
-
bisphosphate 3'-nucleotidase
-
-
BPNT1
-
-
BPntase
Q38945
-
CysQ
-
exhibits also NADP(H) phosphatase and fructose-1,6-bisphosphatase activities
DPNPase
-
-
-
-
GhHL1
Q8VWZ6
-
GhHL1
Gossypium hirsutum CRI 12
Q8VWZ6
-
-
gPAPP
-
-
Halotolerance protein tol1
-
-
-
-
nucleotidase, phosphoadenylate 3'-
-
-
-
-
PAP 3'-phosphatase
-
-
PAP-phosphatease
O95861
-
PAPase
Q3LS17
-
phosphoadenylate 3'-nucleotidase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9025-83-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
-
Q9LKB5
SwissProt
Manually annotated by BRENDA team
GenBank U40433
-
-
Manually annotated by BRENDA team
formerly known as Arthrospira platensis
UniProt
Manually annotated by BRENDA team
Gossypium hirsutum CRI 12
-
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
GenBank AF125042
SwissProt
Manually annotated by BRENDA team
recombinantly expressed in yeast
Uniprot
Manually annotated by BRENDA team
GenBank AF125043
Uniprot
Manually annotated by BRENDA team
GenBank U33283
Uniprot
Manually annotated by BRENDA team
KP767, KP812, KP656, KP801, KP803
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-, Q8VWZ6
overexpression of GhHL1 complements yeast hal2 mutant and enhances yeast growth under elevated NaCl or LiCl, showing a role in salt tolerance associated with ionic stress response
physiological function
Gossypium hirsutum CRI 12
-
overexpression of GhHL1 complements yeast hal2 mutant and enhances yeast growth under elevated NaCl or LiCl, showing a role in salt tolerance associated with ionic stress response
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2.4
-
Li+
-
wild type enzyme, in 50 mM Tris-MES, pH 7.5, 0.5 mM magnesium acetate for 30 min at 30C
3.6
-
Li+
-, Q3LS17
in 50 mM Tris (pH 8.0), 2 mM MgCl2, at 30C
0.05
-
LiCl
-
using adenosine 3',5'-bisphosphate as a substrate
0.15
-
LiCl
-
using adenosine 2',5'-bisphosphate as a substrate
180
-
Na+
-
wild type enzyme, in 50 mM Tris-MES, pH 7.5, 0.5 mM magnesium acetate for 30 min at 30C
600
-
Na+
-, Q3LS17
in 50 mM Tris (pH 8.0), 2 mM MgCl2, at 30C
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
9
-, Q8VWZ6
activity range, highest activity in the pH range from pH 7.0 to pH 8.5
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
-
-, Q8VWZ6
-
30
-
-
assay at
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
10
75
-, Q8VWZ6
highest activity at 30-65C, low activity at below 10C, and 28.9% of maximal activity at 75C
PDB
SCOP
CATH
ORGANISM
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8
-
-
the 3'-PAPase activity is decreased to approximately 50% at pH 8.0
10
-
-, Q3LS17
remained 60% of maximal activity when the pH of the reaction sample is increased to pH 10